IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-43579-3.html
   My bibliography  Save this article

DPPIV+ fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages

Author

Listed:
  • Farshad Babaeijandaghi

    (University of British Columbia
    Altos Labs Inc)

  • Nasim Kajabadi

    (University of British Columbia)

  • Reece Long

    (University of British Columbia)

  • Lin Wei Tung

    (University of British Columbia)

  • Chun Wai Cheung

    (University of British Columbia)

  • Morten Ritso

    (University of British Columbia)

  • Chih-Kai Chang

    (University of British Columbia)

  • Ryan Cheng

    (University of British Columbia)

  • Tiffany Huang

    (University of British Columbia)

  • Elena Groppa

    (University of British Columbia)

  • Jean X. Jiang

    (University of Texas Health Science Center)

  • Fabio M. V. Rossi

    (University of British Columbia)

Abstract

Adult tissue-resident macrophages (RMs) are either maintained by blood monocytes or through self-renewal. While the presence of a nurturing niche is likely crucial to support the survival and function of self-renewing RMs, evidence regarding its nature is limited. Here, we identify fibro-adipogenic progenitors (FAPs) as the main source of colony-stimulating factor 1 (CSF1) in resting skeletal muscle. Using parabiosis in combination with FAP-deficient transgenic mice (PdgfrαCreERT2 × DTA) or mice lacking FAP-derived CSF1 (PdgfrαCreERT2 × Csf1flox/null), we show that local CSF1 from FAPs is required for the survival of both TIM4- monocyte-derived and TIM4+ self-renewing RMs in adult skeletal muscle. The spatial distribution and number of TIM4+ RMs coincide with those of dipeptidyl peptidase IV (DPPIV)+ FAPs, suggesting their role as CSF1-producing niche cells for self-renewing RMs. This finding identifies opportunities to precisely manipulate the function of self-renewing RMs in situ to further unravel their role in health and disease.

Suggested Citation

  • Farshad Babaeijandaghi & Nasim Kajabadi & Reece Long & Lin Wei Tung & Chun Wai Cheung & Morten Ritso & Chih-Kai Chang & Ryan Cheng & Tiffany Huang & Elena Groppa & Jean X. Jiang & Fabio M. V. Rossi, 2023. "DPPIV+ fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43579-3
    DOI: 10.1038/s41467-023-43579-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-43579-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-43579-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Masako Kohyama & Wataru Ise & Brian T. Edelson & Peter R. Wilker & Kai Hildner & Carlo Mejia & William A. Frazier & Theresa L. Murphy & Kenneth M. Murphy, 2009. "Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis," Nature, Nature, vol. 457(7227), pages 318-321, January.
    2. David T. Scadden, 2006. "The stem-cell niche as an entity of action," Nature, Nature, vol. 441(7097), pages 1075-1079, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Graham A. Heieis & Thiago A. Patente & Luís Almeida & Frank Vrieling & Tamar Tak & Georgia Perona-Wright & Rick M. Maizels & Rinke Stienstra & Bart Everts, 2023. "Metabolic heterogeneity of tissue-resident macrophages in homeostasis and during helminth infection," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Surapon Tangvarasittichai, 2018. "Iron Homeostasis and Diabetes Risk," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 7(4), pages 1-11, July.
    3. Fei Pei & Li Ma & Junjun Jing & Jifan Feng & Yuan Yuan & Tingwei Guo & Xia Han & Thach-Vu Ho & Jie Lei & Jinzhi He & Mingyi Zhang & Jian-Fu Chen & Yang Chai, 2023. "Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Joschka Hey & Michelle Paulsen & Reka Toth & Dieter Weichenhan & Simone Butz & Jolanthe Schatterny & Reinhard Liebers & Pavlo Lutsik & Christoph Plass & Marcus A. Mall, 2021. "Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    5. Zhdanov, Vladimir P., 2009. "Signal propagation in stem-cell niches," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 388(18), pages 3791-3797.
    6. Surapon Tangvarasittichai, 2018. "Iron Homeostasis and Diabetes Risk," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 7(4), pages 79-88, July.
    7. Zhdanov, Vladimir P., 2008. "Simulation of proliferation and differentiation of cells in a stem-cell niche," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 387(24), pages 6126-6136.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43579-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.