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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

Author

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  • Jeehye Park

    (National Creative Research Initiatives Center for Cell Growth Regulation
    Korea Advanced Institute of Science and Technology)

  • Sung Bae Lee

    (National Creative Research Initiatives Center for Cell Growth Regulation
    Korea Advanced Institute of Science and Technology)

  • Sungkyu Lee

    (National Creative Research Initiatives Center for Cell Growth Regulation
    Korea Advanced Institute of Science and Technology)

  • Yongsung Kim

    (National Creative Research Initiatives Center for Cell Growth Regulation
    Korea Advanced Institute of Science and Technology)

  • Saera Song

    (National Creative Research Initiatives Center for Cell Growth Regulation
    Korea Advanced Institute of Science and Technology)

  • Sunhong Kim

    (National Creative Research Initiatives Center for Cell Growth Regulation
    Korea Advanced Institute of Science and Technology)

  • Eunkyung Bae

    (GenExel, Inc.)

  • Jaeseob Kim

    (Korea Advanced Institute of Science and Technology
    GenExel, Inc.)

  • Minho Shong

    (Department of Internal Medicine)

  • Jin-Man Kim

    (Chungnam National University School of Medicine)

  • Jongkyeong Chung

    (National Creative Research Initiatives Center for Cell Growth Regulation
    Korea Advanced Institute of Science and Technology)

Abstract

Parkin penalty The PINK1 gene was recently implicated in autosomal recessive juvenile Parkinson's disease. Two groups have studied the equivalent gene in the fruitfly Drosophila, and find that it localizes to mitochondria in vivo and is essential to mitochondrial function. It also interacts genetically with parkin, another familial Parkinson's disease-related gene that encodes Parkin, an E3 ubiquitin ligase. The pink1-parkin pathway in Drosophila should provide a powerful tool for the study of the molecular mechanisms of neurodegeneration and for screening agents of possible therapeutic interest.

Suggested Citation

  • Jeehye Park & Sung Bae Lee & Sungkyu Lee & Yongsung Kim & Saera Song & Sunhong Kim & Eunkyung Bae & Jaeseob Kim & Minho Shong & Jin-Man Kim & Jongkyeong Chung, 2006. "Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin," Nature, Nature, vol. 441(7097), pages 1157-1161, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7097:d:10.1038_nature04788
    DOI: 10.1038/nature04788
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    Cited by:

    1. Kimberly C. Paul & Richard C. Krolewski & Edinson Lucumi Moreno & Jack Blank & Kristina M. Holton & Tim Ahfeldt & Melissa Furlong & Yu Yu & Myles Cockburn & Laura K. Thompson & Alexander Kreymerman & , 2023. "A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Huan Yang & Caroline Sibilla & Raymond Liu & Jina Yun & Bruce A. Hay & Craig Blackstone & David C. Chan & Robert J. Harvey & Ming Guo, 2022. "Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Su Jin Ham & Heesuk Yoo & Daihn Woo & Da Hyun Lee & Kyu-Sang Park & Jongkyeong Chung, 2023. "PINK1 and Parkin regulate IP3R-mediated ER calcium release," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Vanitha Nithianandam & Hassan Bukhari & Matthew J. Leventhal & Rachel A. Battaglia & Xianjun Dong & Ernest Fraenkel & Mel B. Feany, 2023. "Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    5. Jenny Zhe Liao & Hyung-lok Chung & Claire Shih & Kenneth Kin Lam Wong & Debdeep Dutta & Zelha Nil & Catherine Grace Burns & Oguz Kanca & Ye-Jin Park & Zhongyuan Zuo & Paul C. Marcogliese & Katherine S, 2024. "Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    6. Yunpeng Huang & Zhihui Wan & Yinglu Tang & Junxuan Xu & Bretton Laboret & Sree Nallamothu & Chenyu Yang & Boxiang Liu & Rongze Olivia Lu & Bingwei Lu & Juan Feng & Jing Cao & Susan Hayflick & Zhihao W, 2022. "Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    7. Federico Miozzo & Eva P. Valencia-Alarcón & Luca Stickley & Michaëla Majcin Dorcikova & Francesco Petrelli & Damla Tas & Nicolas Loncle & Irina Nikonenko & Peter Bou Dib & Emi Nagoshi, 2022. "Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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