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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Author

Listed:
  • Taichi Hara

    (Tokyo Metropolitan Institute of Medical Science)

  • Kenji Nakamura

    (Mitsubishi Kagaku Institute of Life Sciences)

  • Makoto Matsui

    (Tokyo Metropolitan Institute of Medical Science
    School of Life Science, the Graduate University for Advanced Studies
    National Institute for Basic Biology)

  • Akitsugu Yamamoto

    (Nagahama Institute of Bio-Science and Technology)

  • Yohko Nakahara

    (Mitsubishi Kagaku Institute of Life Sciences)

  • Rika Suzuki-Migishima

    (Mitsubishi Kagaku Institute of Life Sciences)

  • Minesuke Yokoyama

    (Niigata University)

  • Kenji Mishima

    (Tsurumi University School of Dental Medicine)

  • Ichiro Saito

    (Tsurumi University School of Dental Medicine)

  • Hideyuki Okano

    (Keio University School of Medicine
    SORST)

  • Noboru Mizushima

    (Tokyo Metropolitan Institute of Medical Science
    PRESTO, Japan Science and Technology Agency)

Abstract

A tidy cell is a healthy cell Two papers this week suggest that the process of protein degradation and clearance of cellular components may be more important in maintaining the health of the nervous system than was thought. Both groups show that inhibition of autophagy in mouse brain cells results in neurodegeneration and early death. Autophagy, the protein degradation and recycling of cellular components, is important for the normal growth and development of a cell. The finding that the continual clearance of cellular components is essential for maintaining neuronal health should open up new avenues of research into the nature of neurodegenerative diseases.

Suggested Citation

  • Taichi Hara & Kenji Nakamura & Makoto Matsui & Akitsugu Yamamoto & Yohko Nakahara & Rika Suzuki-Migishima & Minesuke Yokoyama & Kenji Mishima & Ichiro Saito & Hideyuki Okano & Noboru Mizushima, 2006. "Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice," Nature, Nature, vol. 441(7095), pages 885-889, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7095:d:10.1038_nature04724
    DOI: 10.1038/nature04724
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    Citations

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    Cited by:

    1. Yoshito Minami & Atsushi Hoshino & Yusuke Higuchi & Masahide Hamaguchi & Yusaku Kaneko & Yuhei Kirita & Shunta Taminishi & Toshiyuki Nishiji & Akiyuki Taruno & Michiaki Fukui & Zoltan Arany & Satoaki , 2023. "Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Afshin Saffari & Barbara Brechmann & Cedric Böger & Wardiya Afshar Saber & Hellen Jumo & Dosh Whye & Delaney Wood & Lara Wahlster & Julian E. Alecu & Marvin Ziegler & Marlene Scheffold & Kellen Winden, 2024. "High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    3. Catherine J. Greene & Jenny A. Nguyen & Samuel M. Cheung & Corey R. Arnold & Dale R. Balce & Ya Ting Wang & Adrian Soderholm & Neil McKenna & Devin Aggarwal & Rhiannon I. Campden & Benjamin W. Ewanchu, 2022. "Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Xiaoting Zhou & You-Kyung Lee & Xianting Li & Henry Kim & Carlos Sanchez-Priego & Xian Han & Haiyan Tan & Suiping Zhou & Yingxue Fu & Kerry Purtell & Qian Wang & Gay R. Holstein & Beisha Tang & Junmin, 2024. "Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    5. Barbara Baldo & Rana Soylu & Åsa Petersén, 2013. "Maintenance of Basal Levels of Autophagy in Huntington’s Disease Mouse Models Displaying Metabolic Dysfunction," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-15, December.
    6. Alexandra K. Davies & Julian E. Alecu & Marvin Ziegler & Catherine G. Vasilopoulou & Fabrizio Merciai & Hellen Jumo & Wardiya Afshar-Saber & Mustafa Sahin & Darius Ebrahimi-Fakhari & Georg H. H. Borne, 2022. "AP-4-mediated axonal transport controls endocannabinoid production in neurons," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    7. Athina Varveri & Miranta Papadopoulou & Zacharias Papadovasilakis & Ewoud B. Compeer & Aigli-Ioanna Legaki & Anastasios Delis & Vasileia Damaskou & Louis Boon & Sevasti Papadogiorgaki & Martina Samiot, 2024. "Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    8. Amy-Jayne Hutchings & Bita Hambrecht & Alexander Veh & Neha Jadhav Giridhar & Abdolhossein Zare & Christina Angerer & Thorben Ohnesorge & Maren Schenke & Bhuvaneish T. Selvaraj & Siddharthan Chandran , 2024. "Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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