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Noise-resistant and synchronized oscillation of the segmentation clock

Author

Listed:
  • Kazuki Horikawa

    (Graduate School of Science, University of Tokyo)

  • Kana Ishimatsu

    (Graduate School of Science, University of Tokyo)

  • Eiichi Yoshimoto

    (Graduate School of Science, Nagoya University, Furo-cho)

  • Shigeru Kondo

    (Graduate School of Science, Nagoya University, Furo-cho)

  • Hiroyuki Takeda

    (Graduate School of Science, University of Tokyo)

Abstract

Periodic somite segmentation in vertebrate embryos is controlled by the ‘segmentation clock’, which consists of numerous cellular oscillators. Although the properties of a single oscillator, driven by a hairy negative-feedback loop, have been investigated, the system-level properties of the segmentation clock remain largely unknown. To explore these characteristics, we have examined the response of a normally oscillating clock in zebrafish to experimental stimuli using in vivo mosaic experiments and mathematical simulation. We demonstrate that the segmentation clock behaves as a coupled oscillator, by showing that Notch-dependent intercellular communication, the activity of which is regulated by the internal hairy oscillator, couples neighbouring cells to facilitate synchronized oscillation. Furthermore, the oscillation phase of individual oscillators fluctuates due to developmental noise such as stochastic gene expression and active cell proliferation. The intercellular coupling was found to have a crucial role in minimizing the effects of this noise to maintain coherent oscillation.

Suggested Citation

  • Kazuki Horikawa & Kana Ishimatsu & Eiichi Yoshimoto & Shigeru Kondo & Hiroyuki Takeda, 2006. "Noise-resistant and synchronized oscillation of the segmentation clock," Nature, Nature, vol. 441(7094), pages 719-723, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7094:d:10.1038_nature04861
    DOI: 10.1038/nature04861
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    Cited by:

    1. Mayu Sugiyama & Takashi Saitou & Hiroshi Kurokawa & Asako Sakaue-Sawano & Takeshi Imamura & Atsushi Miyawaki & Tadahiro Iimura, 2014. "Live Imaging-Based Model Selection Reveals Periodic Regulation of the Stochastic G1/S Phase Transition in Vertebrate Axial Development," PLOS Computational Biology, Public Library of Science, vol. 10(12), pages 1-16, December.
    2. Astakhov, Sergey & Astakhov, Oleg & Fadeeva, Natalia & Astakhov, Vladimir, 2021. "Multistability, quasiperiodicity and chaos in a self-oscillating ring dynamical system with three degrees of freedom based on the van der Pol generator," Chaos, Solitons & Fractals, Elsevier, vol. 148(C).
    3. Kitajima, Hiroyuki & Horikawa, Yo, 2009. "Mechanism of long transient oscillations in cyclic coupled systems," Chaos, Solitons & Fractals, Elsevier, vol. 42(3), pages 1854-1859.

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