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A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting

Author

Listed:
  • Olivier Namy

    (University of Cambridge
    Institut de Génétique et Microbiologie, UMR8621, Université Paris-Sud)

  • Stephen J. Moran

    (Henry Wellcome Building for Genomic Medicine, University of Oxford)

  • David I. Stuart

    (Henry Wellcome Building for Genomic Medicine, University of Oxford
    University of Oxford)

  • Robert J. C. Gilbert

    (Henry Wellcome Building for Genomic Medicine, University of Oxford
    University of Oxford)

  • Ian Brierley

    (University of Cambridge)

Abstract

Tying the pseudoknot Ribosomal frameshifting is a translational mechanism involved in protein synthesis during the replication of many viral pathogens and in cellular genes more generally. A new set of images of an 80S ribosome stalled at an mRNA pseudoknot shows how the pseudoknot manipulates the ribosome into a different reading frame.

Suggested Citation

  • Olivier Namy & Stephen J. Moran & David I. Stuart & Robert J. C. Gilbert & Ian Brierley, 2006. "A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting," Nature, Nature, vol. 441(7090), pages 244-247, May.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7090:d:10.1038_nature04735
    DOI: 10.1038/nature04735
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    Cited by:

    1. Chris H. Hill & Lukas Pekarek & Sawsan Napthine & Anuja Kibe & Andrew E. Firth & Stephen C. Graham & Neva Caliskan & Ian Brierley, 2021. "Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    2. Shuting Yan & Qiyao Zhu & Swati Jain & Tamar Schlick, 2022. "Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppression," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Chen Bao & Mingyi Zhu & Inna Nykonchuk & Hironao Wakabayashi & David H. Mathews & Dmitri N. Ermolenko, 2022. "Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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