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Cortical rewiring and information storage

Author

Listed:
  • D. B. Chklovskii

    (Cold Spring Harbour Laboratory)

  • B. W. Mel

    (University of Southern California)

  • K. Svoboda

    (Cold Spring Harbour Laboratory
    Howard Hughes Medical Institute)

Abstract

Current thinking about long-term memory in the cortex is focused on changes in the strengths of connections between neurons. But ongoing structural plasticity in the adult brain, including synapse formation/elimination and remodelling of axons and dendrites, suggests that memory could also depend on learning-induced changes in the cortical ‘wiring diagram’. Given that the cortex is sparsely connected, wiring plasticity could provide a substantial boost in storage capacity, although at a cost of more elaborate biological machinery and slower learning.

Suggested Citation

  • D. B. Chklovskii & B. W. Mel & K. Svoboda, 2004. "Cortical rewiring and information storage," Nature, Nature, vol. 431(7010), pages 782-788, October.
    • Handle: RePEc:nat:nature:v:431:y:2004:i:7010:d:10.1038_nature03012
    DOI: 10.1038/nature03012
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    Cited by:

    1. Fausto-Sterling, Anne & Coll, Cynthia Garcia & Lamarre, Meaghan, 2012. "Sexing the baby: Part 2 applying dynamic systems theory to the emergences of sex-related differences in infants and toddlers," Social Science & Medicine, Elsevier, vol. 74(11), pages 1693-1702.
    2. Kim, Sang-Yoon & Lim, Woochang, 2015. "Effect of small-world connectivity on fast sparsely synchronized cortical rhythms," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 421(C), pages 109-123.
    3. Michael Fauth & Florentin Wörgötter & Christian Tetzlaff, 2015. "Formation and Maintenance of Robust Long-Term Information Storage in the Presence of Synaptic Turnover," PLOS Computational Biology, Public Library of Science, vol. 11(12), pages 1-22, December.
    4. Moritz Deger & Moritz Helias & Stefan Rotter & Markus Diesmann, 2012. "Spike-Timing Dependence of Structural Plasticity Explains Cooperative Synapse Formation in the Neocortex," PLOS Computational Biology, Public Library of Science, vol. 8(9), pages 1-13, September.
    5. Kamila Janzakova & Ismael Balafrej & Ankush Kumar & Nikhil Garg & Corentin Scholaert & Jean Rouat & Dominique Drouin & Yannick Coffinier & Sébastien Pecqueur & Fabien Alibart, 2023. "Structural plasticity for neuromorphic networks with electropolymerized dendritic PEDOT connections," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    6. Michael Fauth & Florentin Wörgötter & Christian Tetzlaff, 2015. "The Formation of Multi-synaptic Connections by the Interaction of Synaptic and Structural Plasticity and Their Functional Consequences," PLOS Computational Biology, Public Library of Science, vol. 11(1), pages 1-29, January.
    7. Chrisantha Fernando & Vera Vasas & Eörs Szathmáry & Phil Husbands, 2011. "Evolvable Neuronal Paths: A Novel Basis for Information and Search in the Brain," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-24, August.
    8. Spencer L Smith & Joshua T Trachtenberg, 2010. "The Refinement of Ipsilateral Eye Retinotopic Maps Is Increased by Removing the Dominant Contralateral Eye in Adult Mice," PLOS ONE, Public Library of Science, vol. 5(3), pages 1-6, March.
    9. Glenn N Saxe & Daniel Calderone & Leah J Morales, 2018. "Brain entropy and human intelligence: A resting-state fMRI study," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-21, February.

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