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Revealing the world of RNA interference

Author

Listed:
  • Craig C. Mello

    (Howard Hughes Medical Institute, University of Massachusetts Medical School
    Program in Molecular Medicine, University of Massachusetts Medical School)

  • Darryl Conte

    (Program in Molecular Medicine, University of Massachusetts Medical School)

Abstract

The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce the expression of problem genes. At the heart of RNA interference lies a remarkable RNA processing mechanism that is now known to underlie many distinct biological phenomena.

Suggested Citation

  • Craig C. Mello & Darryl Conte, 2004. "Revealing the world of RNA interference," Nature, Nature, vol. 431(7006), pages 338-342, September.
    • Handle: RePEc:nat:nature:v:431:y:2004:i:7006:d:10.1038_nature02872
    DOI: 10.1038/nature02872
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    Cited by:

    1. J. Fulneček, 2007. "Isolation and detection of small RNA molecules," Plant, Soil and Environment, Czech Academy of Agricultural Sciences, vol. 53(10), pages 451-455.
    2. B. Megala Devi & Samyuktha Guruprasath & Pooraniammal Balu & Anirudha Chattopadhyay & Siva Sudha Thilagar & Kanaga Vijayan Dhanabalan & Manoj Choudhary & Swarnalatha Moparthi & A. Abdul Kader Jailani, 2024. "Dissecting Diagnostic and Management Strategies for Plant Viral Diseases: What Next?," Agriculture, MDPI, vol. 14(2), pages 1-31, February.
    3. Zhimin Yin & Bartłomiej Zieniuk & Magdalena Pawełkowicz, 2024. "Climate Change Effects on Cucumber Viruses and Their Management," Agriculture, MDPI, vol. 14(11), pages 1-20, November.

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