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Pathways towards and away from Alzheimer's disease

Author

Listed:
  • Mark P. Mattson

    (National Institute on Aging Intramural Research Program
    Johns Hopkins University School of Medicine)

Abstract

Slowly but surely, Alzheimer's disease (AD) patients lose their memory and their cognitive abilities, and even their personalities may change dramatically. These changes are due to the progressive dysfunction and death of nerve cells that are responsible for the storage and processing of information. Although drugs can temporarily improve memory, at present there are no treatments that can stop or reverse the inexorable neurodegenerative process. But rapid progress towards understanding the cellular and molecular alterations that are responsible for the neuron's demise may soon help in developing effective preventative and therapeutic strategies.

Suggested Citation

  • Mark P. Mattson, 2004. "Pathways towards and away from Alzheimer's disease," Nature, Nature, vol. 430(7000), pages 631-639, August.
    • Handle: RePEc:nat:nature:v:430:y:2004:i:7000:d:10.1038_nature02621
    DOI: 10.1038/nature02621
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    Cited by:

    1. Shu Jiang & Yijun Xie & Graham A. Colditz, 2021. "Functional ensemble survival tree: Dynamic prediction of Alzheimer’s disease progression accommodating multiple time‐varying covariates," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 70(1), pages 66-79, January.
    2. Ngoumen Ngassa Dany Joel & Ngondi Judith Laure & Oben Julius Enyong, 2021. "Effect of Autranella congolensis on Lipid Profile of Rats' Brain with Experimentally Induced Alzheimer's Disease," Journal of Food Research, Canadian Center of Science and Education, vol. 9(4), pages 1-60, December.
    3. Gema Lordén & Jacob M. Wozniak & Kim Doré & Lara E. Dozier & Chelsea Cates-Gatto & Gentry N. Patrick & David J. Gonzalez & Amanda J. Roberts & Rudolph E. Tanzi & Alexandra C. Newton, 2022. "Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Seyed-Ali Sadegh-Zadeh & Chandrasekhar Kambhampati, 2018. "Computational Investigation of Amyloid Peptide Channels in Alzheimer’s Disease," J, MDPI, vol. 2(1), pages 1-14, December.
    5. Ying Shi & Alexander R. Pilozzi & Xudong Huang, 2020. "Exposure of CuO Nanoparticles Contributes to Cellular Apoptosis, Redox Stress, and Alzheimer’s Aβ Amyloidosis," IJERPH, MDPI, vol. 17(3), pages 1-18, February.

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