IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v423y2003i6936d10.1038_nature01605.html
   My bibliography  Save this article

Direct observation of catch bonds involving cell-adhesion molecules

Author

Listed:
  • Bryan T. Marshall

    (Woodruff School of Mechanical Engineering, Georgia Institute of Technology)

  • Mian Long

    (Woodruff School of Mechanical Engineering, Georgia Institute of Technology
    Chinese Academy of Sciences)

  • James W. Piper

    (Woodruff School of Mechanical Engineering, Georgia Institute of Technology
    Immucor, Inc.)

  • Tadayuki Yago

    (University of Oklahoma Health Sciences Center)

  • Rodger P. McEver

    (University of Oklahoma Health Sciences Center
    University of Oklahoma Health Sciences Center)

  • Cheng Zhu

    (Woodruff School of Mechanical Engineering, Georgia Institute of Technology
    Georgia Institute of Technology)

Abstract

Bonds between adhesion molecules are often mechanically stressed. A striking example is the tensile force applied to selectin–ligand bonds, which mediate the tethering and rolling of flowing leukocytes on vascular surfaces1,2,3. It has been suggested that force could either shorten bond lifetimes, because work done by the force could lower the energy barrier between the bound and free states4 (‘slip’), or prolong bond lifetimes by deforming the molecules such that they lock more tightly5,6 (‘catch’). Whereas slip bonds have been widely observed7,8,9,10,11,12,13,14, catch bonds have not been demonstrated experimentally. Here, using atomic force microscopy and flow-chamber experiments, we show that increasing force first prolonged and then shortened the lifetimes of P-selectin complexes with P-selectin glycoprotein ligand-1, revealing both catch and slip bond behaviour. Transitions between catch and slip bonds might explain why leukocyte rolling on selectins first increases and then decreases as wall shear stress increases9,15,16. This dual response to force provides a mechanism for regulating cell adhesion under conditions of variable mechanical stress.

Suggested Citation

  • Bryan T. Marshall & Mian Long & James W. Piper & Tadayuki Yago & Rodger P. McEver & Cheng Zhu, 2003. "Direct observation of catch bonds involving cell-adhesion molecules," Nature, Nature, vol. 423(6936), pages 190-193, May.
  • Handle: RePEc:nat:nature:v:423:y:2003:i:6936:d:10.1038_nature01605
    DOI: 10.1038/nature01605
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature01605
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature01605?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Brian J Schmidt & Jason A Papin & Michael B Lawrence, 2009. "Nano-motion Dynamics are Determined by Surface-Tethered Selectin Mechanokinetics and Bond Formation," PLOS Computational Biology, Public Library of Science, vol. 5(12), pages 1-19, December.
    2. Ying Hung & Li‐Hsiang Lin & C. F. Jeff Wu, 2022. "Varying coefficient frailty models with applications in single molecular experiments," Biometrics, The International Biometric Society, vol. 78(2), pages 474-486, June.
    3. Hyun-Kyu Choi & Peiwen Cong & Chenghao Ge & Aswin Natarajan & Baoyu Liu & Yong Zhang & Kaitao Li & Muaz Nik Rushdi & Wei Chen & Jizhong Lou & Michelle Krogsgaard & Cheng Zhu, 2023. "Catch bond models may explain how force amplifies TCR signaling and antigen discrimination," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Valentina Lo Schiavo & Philippe Robert & Laurent Limozin & Pierre Bongrand, 2012. "Quantitative Modeling Assesses the Contribution of Bond Strengthening, Rebinding and Force Sharing to the Avidity of Biomolecule Interactions," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-11, September.
    5. Navish Wadhwa & Alberto Sassi & Howard C. Berg & Yuhai Tu, 2022. "A multi-state dynamic process confers mechano-adaptation to a biological nanomachine," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    6. Nicola Hellen & Gregory I. Mashanov & Ianina L. Conte & Sophie Trionnaire & Victor Babich & Laura Knipe & Alamin Mohammed & Kazim Ogmen & Silvia Martin-Almedina & Katalin Török & Matthew J. Hannah & J, 2022. "P-selectin mobility undergoes a sol-gel transition as it diffuses from exocytosis sites into the cell membrane," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    7. Muaz Nik Rushdi & Victor Pan & Kaitao Li & Hyun-Kyu Choi & Stefano Travaglino & Jinsung Hong & Fletcher Griffitts & Pragati Agnihotri & Roy A. Mariuzza & Yonggang Ke & Cheng Zhu, 2022. "Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    8. Zhaowei Liu & Haipei Liu & Andrés M. Vera & Byeongseon Yang & Philip Tinnefeld & Michael A. Nash, 2024. "Engineering an artificial catch bond using mechanical anisotropy," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:423:y:2003:i:6936:d:10.1038_nature01605. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.