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The cytoskeleton, cellular motility and the reductionist agenda

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  • Thomas D. Pollard

    (Cellular and Developmental Biology, Yale University)

Abstract

Eukaryotic cells depend on cytoskeletal polymers and molecular motors to establish their asymmetrical shapes, to transport intracellular constituents and to drive their motility. Cell biologists are using diverse experimental approaches to understand the molecular basis of cellular movements and to explain why defects in the component proteins cause disease. Much of the molecular machinery for motility evolved in early eukaryotes, so a limited set of general principles can explain the motility of most cells.

Suggested Citation

  • Thomas D. Pollard, 2003. "The cytoskeleton, cellular motility and the reductionist agenda," Nature, Nature, vol. 422(6933), pages 741-745, April.
    • Handle: RePEc:nat:nature:v:422:y:2003:i:6933:d:10.1038_nature01598
    DOI: 10.1038/nature01598
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    Cited by:

    1. Peter J M Van Haastert, 2010. "A Model for a Correlated Random Walk Based on the Ordered Extension of Pseudopodia," PLOS Computational Biology, Public Library of Science, vol. 6(8), pages 1-11, August.
    2. Jie Zhu & Alex Mogilner, 2012. "Mesoscopic Model of Actin-Based Propulsion," PLOS Computational Biology, Public Library of Science, vol. 8(11), pages 1-12, November.
    3. Jonathan B Alberts & Garrett M Odell, 2004. "In Silico Reconstitution of Listeria Propulsion Exhibits Nano-Saltation," PLOS Biology, Public Library of Science, vol. 2(12), pages 1-1, November.
    4. Leonard Bosgraaf & Peter J M Van Haastert, 2009. "The Ordered Extension of Pseudopodia by Amoeboid Cells in the Absence of External Cues," PLOS ONE, Public Library of Science, vol. 4(4), pages 1-13, April.

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