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Effects of mechanical forces on maintenance and adaptation of form in trabecular bone

Author

Listed:
  • Rik Huiskes

    (Orthopaedic Research Lab, University of Nijmegen)

  • Ronald Ruimerman

    (Orthopaedic Research Lab, University of Nijmegen
    Eindhoven University of Technology)

  • G. Harry van Lenthe

    (Orthopaedic Research Lab, University of Nijmegen)

  • Jan D. Janssen

    (Faculty of Biomedical Engineering, Eindhoven University of Technology)

Abstract

The architecture of trabecular bone, the porous bone found in the spine and at articulating joints, provides the requirements for optimal load transfer, by pairing suitable strength and stiffness to minimal weight according to rules of mathematical design1,2,3,4,5,6. But, as it is unlikely that the architecture is fully pre-programmed in the genes7, how are the bone cells informed about these rules, which so obviously dictate architecture? A relationship exists between bone architecture and mechanical usage8—while strenuous exercise increases bone mass9, disuse, as in microgravity and inactivity, reduces it10. Bone resorption cells (osteoclasts) and bone formation cells (osteoblasts) normally balance bone mass in a coupled homeostatic process of remodelling, which renews some 25% of trabecular bone volume per year. Here we present a computational model of the metabolic process in bone that confirms that cell coupling is governed by feedback from mechanical load transfer11,12,13.This model can explain the emergence and maintenance of trabecular architecture as an optimal mechanical structure, as well as its adaptation to alternative external loads.

Suggested Citation

  • Rik Huiskes & Ronald Ruimerman & G. Harry van Lenthe & Jan D. Janssen, 2000. "Effects of mechanical forces on maintenance and adaptation of form in trabecular bone," Nature, Nature, vol. 405(6787), pages 704-706, June.
    • Handle: RePEc:nat:nature:v:405:y:2000:i:6787:d:10.1038_35015116
    DOI: 10.1038/35015116
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    Citations

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    Cited by:

    1. Bríanne M. Mulvihill & Patrick J. Prendergast, 2008. "An algorithm for bone mechanoresponsiveness: implementation to study the effect of patient-specific cell mechanosensitivity on trabecular bone loss," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 11(5), pages 443-451.
    2. Rabeb Ben Kahla & Abdelwahed Barkaoui & Moez Chafra & João Manuel R. S. Tavares, 2021. "A General Mechano-Pharmaco-Biological Model for Bone Remodeling Including Cortisol Variation," Mathematics, MDPI, vol. 9(12), pages 1-18, June.
    3. Hong Seok Park & Dinh Son Nguyen & Thai Le-Hong & Xuan Tran, 2022. "Machine learning-based optimization of process parameters in selective laser melting for biomedical applications," Journal of Intelligent Manufacturing, Springer, vol. 33(6), pages 1843-1858, August.
    4. Gustav Lindberg & Leslie Banks-Sills & Per Ståhle & Ingrid Svensson, 2015. "A two-dimensional model for stress driven diffusion in bone tissue," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 18(5), pages 457-467, April.
    5. S. Aland & C. Landsberg & R. Müller & F. Stenger & M. Bobeth & A.C. Langheinrich & A. Voigt, 2014. "Adaptive diffuse domain approach for calculating mechanically induced deformation of trabecular bone," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 17(1), pages 31-38, January.
    6. Misaki Sakashita & Shintaro Yamasaki & Kentaro Yaji & Atsushi Kawamoto & Shigeru Kondo, 2021. "Three-dimensional topology optimization model to simulate the external shapes of bone," PLOS Computational Biology, Public Library of Science, vol. 17(6), pages 1-23, June.
    7. Mahsa Bahari & Farzam Farahmand & Gholamreza Rouhi & Mohammad Movahhedy, 2012. "Prediction of shape and internal structure of the proximal femur using a modified level set method for structural topology optimisation," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 15(8), pages 835-844.
    8. Alexander Tsouknidas & Georgios Maliaris & Savvas Savvakis & Nikolaos Michailidis, 2015. "Anisotropic post-yield response of cancellous bone simulated by stress–strain curves of bulk equivalent structures," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 18(8), pages 839-846, June.
    9. Dominique P. Pioletti, 2010. "Biomechanics in bone tissue engineering," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 13(6), pages 837-846.
    10. M.A. Pérez & P. Fornells & M. Doblaré & J.M. García-Aznar, 2010. "Comparative analysis of bone remodelling models with respect to computerised tomography-based finite element models of bone," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 13(1), pages 71-80.
    11. Chao Wang & Lizhen Wang & Xiaoyu Liu & Yubo Fan, 2014. "Numerical simulation of the remodelling process of trabecular architecture around dental implants," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 17(3), pages 286-295, February.
    12. Vincent A. Stadelmann & Jean Hocké & Jensen Verhelle & Vincent Forster & Francesco Merlini & Alexandre Terrier & Dominique P. Pioletti, 2009. "3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 12(1), pages 95-100.

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