IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v403y2000i6770d10.1038_35001068.html
   My bibliography  Save this article

Altered brain response to verbal learning following sleep deprivation

Author

Listed:
  • Sean P. A. Drummond

    (University of California San Diego
    Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California San Diego)

  • Gregory G. Brown

    (University of California San Diego
    Psychiatry Service (116A), Veterans Administration San Diego Healthcare System)

  • J. Christian Gillin

    (University of California San Diego
    Psychiatry Service (116A), Veterans Administration San Diego Healthcare System)

  • John L. Stricker

    (University of California San Diego
    Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California San Diego)

  • Eric C. Wong

    (University of California San Diego
    University of California San Diego)

  • Richard B. Buxton

    (University of California San Diego)

Abstract

The effects of sleep deprivation on the neural substrates of cognition are poorly understood. Here we used functional magnetic resonance imaging to measure the effects of 35 hours of sleep deprivation on cerebral activation during verbal learning in normal young volunteers. On the basis of a previous hypothesis1, we predicted that the prefrontal cortex (PFC) would be less responsive to cognitive demands following sleep deprivation. Contrary to our expectations, however, the PFC was more responsive after one night of sleep deprivation than after normal sleep. Increased subjective sleepiness in sleep-deprived subjects correlated significantly with activation of the PFC. The temporal lobe was activated after normal sleep but not after sleep deprivation; in contrast, the parietal lobes were not activated after normal sleep but were activated after sleep deprivation. Although sleep deprivation significantly impaired free recall compared with the rested state, better free recall in sleep-deprived subjects was associated with greater parietal lobe activation. These findings show that there are dynamic, compensatory changes in cerebral activation during verbal learning after sleep deprivation and implicate the PFC and parietal lobes in this compensation.

Suggested Citation

  • Sean P. A. Drummond & Gregory G. Brown & J. Christian Gillin & John L. Stricker & Eric C. Wong & Richard B. Buxton, 2000. "Altered brain response to verbal learning following sleep deprivation," Nature, Nature, vol. 403(6770), pages 655-657, February.
    • Handle: RePEc:nat:nature:v:403:y:2000:i:6770:d:10.1038_35001068
    DOI: 10.1038/35001068
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35001068
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35001068?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Noelia Durán-Gómez & Jorge Guerrero-Martín & Demetrio Pérez-Civantos & Casimiro Fermín López-Jurado & Jesús Montanero-Fernández & Macarena C. Cáceres, 2021. "Night Shift and Decreased Brain Activity of ICU Nurses: A Near-Infrared Spectroscopy Study," IJERPH, MDPI, vol. 18(22), pages 1-14, November.
    2. Dickinson, David L. & McElroy, Todd, 2019. "Bayesian versus heuristic-based choice under sleep restriction and suboptimal times of day," Games and Economic Behavior, Elsevier, vol. 115(C), pages 48-59.
    3. Dickinson, David L. & Drummond, Sean P. A., 2008. "The effects of total sleep deprivation on bayesian updating," Judgment and Decision Making, Cambridge University Press, vol. 3(2), pages 181-190, February.
    4. repec:cup:judgdm:v:3:y:2008:i::p:181-190 is not listed on IDEAS
    5. June Pilcher & Holly Geldhauser & J. Beeco & Tracy Lindquist, 2013. "Controlled Attention and Sleep Deprivation: Adding a Self-Regulation Approach?," International Journal of Psychological Studies, Canadian Center of Science and Education, vol. 5(3), pages 1-71, September.
    6. Dickinson, David L. & McElroy, Todd, 2017. "Sleep restriction and circadian effects on social decisions," European Economic Review, Elsevier, vol. 97(C), pages 57-71.
    7. Dickinson, David L. & Drummond, Sean P. A., 2008. "The effects of total sleep deprivation on bayesian updating," Judgment and Decision Making, Cambridge University Press, vol. 3(2), pages 181-190, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:403:y:2000:i:6770:d:10.1038_35001068. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.