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Genetic instabilities in human cancers

Author

Listed:
  • Christoph Lengauer

    (Johns Hopkins Oncology Center and B. Vogelstein is at the Howard Hughes Medical Institute)

  • Kenneth W. Kinzler

    (Johns Hopkins Oncology Center and B. Vogelstein is at the Howard Hughes Medical Institute)

  • Bert Vogelstein

    (Johns Hopkins Oncology Center and B. Vogelstein is at the Howard Hughes Medical Institute)

Abstract

Whether and how human tumours are genetically unstable has been debated for decades. There is now evidence that most cancers may indeed be genetically unstable, but that the instability exists at two distinct levels. In a small subset of tumours, the instability is observed at the nucleotide level and results in base substitutions or deletions or insertions of a few nucleotides. In most other cancers, the instability is observed at the chromosome level, resulting in losses and gains of whole chromosomes or large portions thereof. Recognition and comparison of these instabilities are leading to new insights into tumour pathogenesis.

Suggested Citation

  • Christoph Lengauer & Kenneth W. Kinzler & Bert Vogelstein, 1998. "Genetic instabilities in human cancers," Nature, Nature, vol. 396(6712), pages 643-649, December.
    • Handle: RePEc:nat:nature:v:396:y:1998:i:6712:d:10.1038_25292
    DOI: 10.1038/25292
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    Cited by:

    1. Signe Penner-Goeke & Zelda Lichtensztejn & Megan Neufeld & Jennifer L Ali & Alon D Altman & Mark W Nachtigal & Kirk J McManus, 2017. "The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samples," PLOS Genetics, Public Library of Science, vol. 13(4), pages 1-24, April.
    2. van Wieringen Wessel N. & van de Wiel Mark A., 2014. "Penalized differential pathway analysis of integrative oncogenomics studies," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 13(2), pages 141-158, April.
    3. Paul R. Rosenbaum, 2004. "The Case-Only Odds Ratio as a Causal Parameter," Biometrics, The International Biometric Society, vol. 60(1), pages 233-240, March.
    4. Rui Zhao & Franziska Michor, 2013. "Patterns of Proliferative Activity in the Colonic Crypt Determine Crypt Stability and Rates of Somatic Evolution," PLOS Computational Biology, Public Library of Science, vol. 9(6), pages 1-15, June.
    5. Zimo Yang & Tao Zhou & Pak Ming Hui & Jian-Hong Ke, 2012. "Instability in Evolutionary Games," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-9, November.
    6. Weissman, Daniel B. & Desai, Michael M. & Fisher, Daniel S. & Feldman, Marcus W., 2009. "The rate at which asexual populations cross fitness valleys," Theoretical Population Biology, Elsevier, vol. 75(4), pages 286-300.
    7. Weifeng Tang & Hao Qiu & Hao Ding & Bin Sun & Lixin Wang & Jun Yin & Haiyong Gu, 2013. "Association between the STK15 F31I Polymorphism and Cancer Susceptibility: A Meta-Analysis Involving 43,626 Subjects," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-1, December.
    8. Beibei Ru & Jinlin Huang & Yu Zhang & Kenneth Aldape & Peng Jiang, 2023. "Estimation of cell lineages in tumors from spatial transcriptomics data," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    9. Simão, Éder M. & Cabral, Heleno B. & Castro, Mauro A.A. & Sinigaglia, Marialva & Mombach, José C.M. & Librelotto, Giovani R., 2010. "Modeling the Human Genome Maintenance network," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 389(19), pages 4188-4194.
    10. Sergi Elizalde & Ashley M Laughney & Samuel F Bakhoum, 2018. "A Markov chain for numerical chromosomal instability in clonally expanding populations," PLOS Computational Biology, Public Library of Science, vol. 14(9), pages 1-28, September.
    11. Fenglong Bie & Zhijie Wang & Yulong Li & Wei Guo & Yuanyuan Hong & Tiancheng Han & Fang Lv & Shunli Yang & Suxing Li & Xi Li & Peiyao Nie & Shun Xu & Ruochuan Zang & Moyan Zhang & Peng Song & Feiyue F, 2023. "Multimodal analysis of cell-free DNA whole-methylome sequencing for cancer detection and localization," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    12. Yoon Hee Cho & Su Young Kim & Hae Dong Woo & Yang Jee Kim & Sung Whan Ha & Hai Won Chung, 2015. "Delayed Numerical Chromosome Aberrations in Human Fibroblasts by Low Dose of Radiation," IJERPH, MDPI, vol. 12(12), pages 1-11, December.

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