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Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro

Author

Listed:
  • André Fisahn

    (MRC Anatomical Neuropharmacology Unit, Mansfield Road)

  • Fenella G. Pike

    (MRC Anatomical Neuropharmacology Unit, Mansfield Road)

  • Eberhard H. Buhl

    (MRC Anatomical Neuropharmacology Unit, Mansfield Road)

  • Ole Paulsen

    (MRC Anatomical Neuropharmacology Unit, Mansfield Road)

Abstract

Acetylcholine is vital for cognitive functions of the brain. Although its actions in the individual cell are known in some detail1, its effects at the network level are poorly understood2. The hippocampus, which receives a major cholinergic input from the medial septum/diagonal band3, is important in memory4,5 and exhibits network activity at 40 Hz during relevant behaviours6. Here we show that cholinergic activation is sufficient to induce 40-Hz network oscillations7 in the hippocampus in vitro. Oscillatory activity is generated spontaneously in the CA3 subfield and can persist for hours. During the oscillatory state, principal neurons fire action potentials that are phase-related to the extracellular oscillation, but each neuron fires in only a small proportion of the cycles. Both excitatory and inhibitory synaptic events participate during the network oscillation in a precise temporal pattern. These results indicate that subcortical cholinergic input can control hippocampal memory processing by inducing fast network oscillations.

Suggested Citation

  • André Fisahn & Fenella G. Pike & Eberhard H. Buhl & Ole Paulsen, 1998. "Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro," Nature, Nature, vol. 394(6689), pages 186-189, July.
    • Handle: RePEc:nat:nature:v:394:y:1998:i:6689:d:10.1038_28179
    DOI: 10.1038/28179
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    Cited by:

    1. Chinnakkaruppan Adaikkan & Justin Joseph & Georgios Foustoukos & Jun Wang & Denis Polygalov & Roman Boehringer & Steven J. Middleton & Arthur J. Y. Huang & Li-Huei Tsai & Thomas J. McHugh, 2024. "Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Kim, Sang-Yoon & Lim, Woochang, 2015. "Effect of small-world connectivity on fast sparsely synchronized cortical rhythms," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 421(C), pages 109-123.
    3. Oscar J Avella Gonzalez & Karlijn I van Aerde & Huibert D Mansvelder & Jaap van Pelt & Arjen van Ooyen, 2014. "Inter-Network Interactions: Impact of Connections between Oscillatory Neuronal Networks on Oscillation Frequency and Pattern," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-16, July.

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