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Dendritic cells and the control of immunity

Author

Listed:
  • Jacques Banchereau

    (Baylor Institute for Immunology, Research, Baylor Research Institute
    Laboratory of Cellular Physiology and Immunology, Rockefeller University)

  • Ralph M. Steinman

    (Baylor Institute for Immunology, Research, Baylor Research Institute
    Laboratory of Cellular Physiology and Immunology, Rockefeller University)

Abstract

B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic cells in the periphery capture and process antigens, express lymphocyte co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. They not only activate lymphocytes, they also tolerize T cells to antigens that are innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell biological analysis. With knowledge comes the realization that these cells are a powerful tool for manipulating the immune system.

Suggested Citation

  • Jacques Banchereau & Ralph M. Steinman, 1998. "Dendritic cells and the control of immunity," Nature, Nature, vol. 392(6673), pages 245-252, March.
    • Handle: RePEc:nat:nature:v:392:y:1998:i:6673:d:10.1038_32588
    DOI: 10.1038/32588
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    1. Dominic Henn & Dehua Zhao & Dharshan Sivaraj & Artem Trotsyuk & Clark Andrew Bonham & Katharina S. Fischer & Tim Kehl & Tobias Fehlmann & Autumn H. Greco & Hudson C. Kussie & Sylvia E. Moortgat Illouz, 2023. "Cas9-mediated knockout of Ndrg2 enhances the regenerative potential of dendritic cells for wound healing," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Thanh Loc Nguyen & Youngjin Choi & Jihye Im & Hyunsu Shin & Ngoc Man Phan & Min Kyung Kim & Seung Woo Choi & Jaeyun Kim, 2022. "Immunosuppressive biomaterial-based therapeutic vaccine to treat multiple sclerosis via re-establishing immune tolerance," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Yael Korem & Pablo Szekely & Yuval Hart & Hila Sheftel & Jean Hausser & Avi Mayo & Michael E Rothenberg & Tomer Kalisky & Uri Alon, 2015. "Geometry of the Gene Expression Space of Individual Cells," PLOS Computational Biology, Public Library of Science, vol. 11(7), pages 1-27, July.
    4. K. Brad Wray & Søren R. Paludan & Lutz Bornmann & Robin Haunschild, 2024. "Using Reference Publication Year Spectroscopy (RPYS) to analyze the research and publication culture in immunology," Scientometrics, Springer;Akadémiai Kiadó, vol. 129(6), pages 3271-3283, June.
    5. Kulvinder Kochar Kaur & Gautam Allahbadia & Mandeep Singh, 2016. "Advances in the Therapy of Advanced Ovarian Cancer-Special Emphasis on the PD1/PDL1 Pathway," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 1(2), pages 32-40, December.
    6. Sahil Inamdar & Abhirami P. Suresh & Joslyn L. Mangal & Nathan D. Ng & Alison Sundem & Christopher Wu & Kelly Lintecum & Abhirami Thumsi & Taravat Khodaei & Michelle Halim & Nicole Appel & Madhan Moha, 2023. "Rescue of dendritic cells from glycolysis inhibition improves cancer immunotherapy in mice," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    7. Bangyuan Wu & Hengmin Cui & Xi Peng & Jing Fang & Zhicai Zuo & Junliang Deng & Jianying Huang, 2014. "Analysis of the Toll-Like Receptor 2-2 (TLR2-2) and TLR4 mRNA Expression in the Intestinal Mucosal Immunity of Broilers Fed on Diets Supplemented with Nickel Chloride," IJERPH, MDPI, vol. 11(1), pages 1-14, January.
    8. Caroline Hoffmann & Floriane Noel & Maximilien Grandclaudon & Lucile Massenet-Regad & Paula Michea & Philemon Sirven & Lilith Faucheux & Aurore Surun & Olivier Lantz & Mylene Bohec & Jian Ye & Weihua , 2022. "PD-L1 and ICOSL discriminate human Secretory and Helper dendritic cells in cancer, allergy and autoimmunity," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    9. Iraj Hosseini & Lucio Gama & Feilim Mac Gabhann, 2015. "Multiplexed Component Analysis to Identify Genes Contributing to the Immune Response during Acute SIV Infection," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-28, May.
    10. Kalijn F. Bol & Gerty Schreibelt & Martine Bloemendal & Wouter W. Willigen & Simone Hins-de Bree & Anna L. Goede & Annemiek J. Boer & Kevin J. H. Bos & Tjitske Duiveman-de Boer & Michel A. M. Olde Nor, 2024. "Adjuvant dendritic cell therapy in stage IIIB/C melanoma: the MIND-DC randomized phase III trial," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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