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K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons

Author

Listed:
  • Dax A. Hoffman

    (Baylor College of Medicine)

  • Jeffrey C. Magee

    (Louisiana State University Medical Center)

  • Costa M. Colbert

    (Baylor College of Medicine)

  • Daniel Johnston

    (Baylor College of Medicine)

Abstract

Pyramidal neurons receive tens of thousands of synaptic inputs on their dendrites. The dendrites dynamically alter the strengths of these synapses and coordinate them to produce an output in ways that are not well understood. Surprisingly, there turns out to be a very high density of transient A-type potassium ion channels in dendrites of hippocampal CA1 pyramidal neurons. These channels prevent initiation of an action potential in the dendrites, limit the back-propagation of action potentials into the dendrites, and reduce excitatory synaptic events. The channels act to prevent large, rapid dendritic depolarizations, thereby regulating orthograde and retrograde propagation of dendritic potentials.

Suggested Citation

  • Dax A. Hoffman & Jeffrey C. Magee & Costa M. Colbert & Daniel Johnston, 1997. "K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons," Nature, Nature, vol. 387(6636), pages 869-875, June.
    • Handle: RePEc:nat:nature:v:387:y:1997:i:6636:d:10.1038_43119
    DOI: 10.1038/43119
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    Cited by:

    1. Zhenrui Liao & Kevin C. Gonzalez & Deborah M. Li & Catalina M. Yang & Donald Holder & Natalie E. McClain & Guofeng Zhang & Stephen W. Evans & Mariya Chavarha & Jane Simko & Christopher D. Makinson & M, 2024. "Functional architecture of intracellular oscillations in hippocampal dendrites," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Liu, Yaru & Liu, Shenquan & Zhan, Feibiao & Zhang, Xiaohan, 2020. "Firing patterns of the modified Hodgkin–Huxley models subject to Taylor ’s formula," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 547(C).
    3. Francisco J H Heras & Mikko Vähäsöyrinki & Jeremy E Niven, 2018. "Modulation of voltage-dependent K+ conductances in photoreceptors trades off investment in contrast gain for bandwidth," PLOS Computational Biology, Public Library of Science, vol. 14(11), pages 1-33, November.

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