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Transcriptional activation by recruitment

Author

Listed:
  • Mark Ptashne

    (Harvard University)

  • Alexander Gann

    (Lancaster University)

Abstract

The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating regions and their targets, and for the role of histones in gene regulation.

Suggested Citation

  • Mark Ptashne & Alexander Gann, 1997. "Transcriptional activation by recruitment," Nature, Nature, vol. 386(6625), pages 569-577, April.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6625:d:10.1038_386569a0
    DOI: 10.1038/386569a0
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    Citations

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    Cited by:

    1. Till D Frank & Aimée M Carmody & Boris N Kholodenko, 2012. "Versatility of Cooperative Transcriptional Activation: A Thermodynamical Modeling Analysis for Greater-Than-Additive and Less-Than-Additive Effects," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-15, April.
    2. Krishanpal Anamika & Àkos Gyenis & Laetitia Poidevin & Olivier Poch & Làszlò Tora, 2012. "RNA Polymerase II Pausing Downstream of Core Histone Genes Is Different from Genes Producing Polyadenylated Transcripts," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-14, June.
    3. Miaomiao Li & Tao Yao & Wanru Lin & Will E. Hinckley & Mary Galli & Wellington Muchero & Andrea Gallavotti & Jin-Gui Chen & Shao-shan Carol Huang, 2023. "Double DAP-seq uncovered synergistic DNA binding of interacting bZIP transcription factors," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    4. Lala M Motlhabi & Gary D Stormo, 2011. "Assessing the Effects of Symmetry on Motif Discovery and Modeling," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-8, September.
    5. T.J.M. van Dooren, 1998. "The Evolutionary Ecology of Dominance-Recessivity," Working Papers ir98096, International Institute for Applied Systems Analysis.
    6. Ying Liang & Haiyue Xu & Tao Cheng & Yujuan Fu & Hanwei Huang & Wenchang Qian & Junyan Wang & Yuenan Zhou & Pengxu Qian & Yafei Yin & Pengfei Xu & Wei Zou & Baohui Chen, 2022. "Gene activation guided by nascent RNA-bound transcription factors," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    7. Michael E Wall & David A Markowitz & Judah L Rosner & Robert G Martin, 2009. "Model of Transcriptional Activation by MarA in Escherichia coli," PLOS Computational Biology, Public Library of Science, vol. 5(12), pages 1-11, December.
    8. Alistair N Boettiger & Peter L Ralph & Steven N Evans, 2011. "Transcriptional Regulation: Effects of Promoter Proximal Pausing on Speed, Synchrony and Reliability," PLOS Computational Biology, Public Library of Science, vol. 7(5), pages 1-14, May.
    9. Rutger Hermsen & Bas Ursem & Pieter Rein ten Wolde, 2010. "Combinatorial Gene Regulation Using Auto-Regulation," PLOS Computational Biology, Public Library of Science, vol. 6(6), pages 1-13, June.

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