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More hippocampal neurons in adult mice living in an enriched environment

Author

Listed:
  • Gerd Kempermann

    (Laboratory of Genetics)

  • H. Georg Kuhn

    (Laboratory of Genetics)

  • Fred H. Gage

    (Laboratory of Genetics)

Abstract

Neurogenesis occurs in the dentate gyrus of the hippocampus throughout the life of a rodent1–4, but the function of these new neurons and the mechanisms that regulate their birth are unknown. Here we show that significantly more new neurons exist in the dentate gyrus of mice exposed to an enriched environment compared with littermates housed in standard cages. We also show, using unbiased stereology, that the enriched mice have a larger hippocampal granule cell layer and 15 per cent more granule cell neurons in the dentate gyrus.

Suggested Citation

  • Gerd Kempermann & H. Georg Kuhn & Fred H. Gage, 1997. "More hippocampal neurons in adult mice living in an enriched environment," Nature, Nature, vol. 386(6624), pages 493-495, April.
    • Handle: RePEc:nat:nature:v:386:y:1997:i:6624:d:10.1038_386493a0
    DOI: 10.1038/386493a0
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    1. Jessica L Reed & Enrico D’Ambrosio & Stefano Marenco & Gianluca Ursini & Amanda B Zheutlin & Giuseppe Blasi & Barbara E Spencer & Raffaella Romano & Jesse Hochheiser & Ann Reifman & Justin Sturm & Kar, 2018. "Interaction of childhood urbanicity and variation in dopamine genes alters adult prefrontal function as measured by functional magnetic resonance imaging (fMRI)," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-20, April.
    2. Jamie L Hanson & Amitabh Chandra & Barbara L Wolfe & Seth D Pollak, 2011. "Association between Income and the Hippocampus," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-8, May.
    3. Obregon, Carlos, 2023. "Institutionalism and Liberalism," MPRA Paper 122455, University Library of Munich, Germany.
    4. Alexander Kotrschal & Barbara Taborsky, 2010. "Environmental Change Enhances Cognitive Abilities in Fish," PLOS Biology, Public Library of Science, vol. 8(4), pages 1-7, April.
    5. Wen-Chung Liu & Chih-Wei Wu & Pi-Lien Hung & Julie Y. H. Chan & You-Lin Tain & Mu-Hui Fu & Lee-Wei Chen & Chih-Kuang Liang & Chun-Ying Hung & Hong-Ren Yu & I-Chun Chen & Kay L.H. Wu, 2020. "Environmental Stimulation Counteracts the Suppressive Effects of Maternal High-Fructose Diet on Cell Proliferation and Neuronal Differentiation in the Dentate Gyrus of Adult Female Offspring via Histo," IJERPH, MDPI, vol. 17(11), pages 1-15, June.
    6. Sven Akkerman & Jos Prickaerts & Ann K Bruder & Kevin H M Wolfs & Jochen De Vry & Tim Vanmierlo & Arjan Blokland, 2014. "PDE5 Inhibition Improves Object Memory in Standard Housed Rats but Not in Rats Housed in an Enriched Environment: Implications for Memory Models?," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-11, November.
    7. Manvendra Singh & Ying Zhao & Vinicius Daguano Gastaldi & Sonja M. Wojcik & Yasmina Curto & Riki Kawaguchi & Ricardo M. Merino & Laura Fernandez Garcia-Agudo & Holger Taschenberger & Nils Brose & Dani, 2023. "Erythropoietin re-wires cognition-associated transcriptional networks," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    8. Alexandros A. Lavdas & Nikos A. Salingaros, 2021. "Can Suboptimal Visual Environments Negatively Affect Children’s Cognitive Development?," Challenges, MDPI, vol. 12(2), pages 1-12, November.
    9. M. Agustina Frechou & Sunaina S. Martin & Kelsey D. McDermott & Evan A. Huaman & Şölen Gökhan & Wolfgang A. Tomé & Ruben Coen-Cagli & J. Tiago Gonçalves, 2024. "Adult neurogenesis improves spatial information encoding in the mouse hippocampus," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    10. Kai Diederich & Wolf-Rüdiger Schäbitz & Katharina Kuhnert & Nina Hellström & Norbert Sachser & Armin Schneider & Hans-Georg Kuhn & Stefan Knecht, 2009. "Synergetic Effects of Granulocyte-Colony Stimulating Factor and Cognitive Training on Spatial Learning and Survival of Newborn Hippocampal Neurons," PLOS ONE, Public Library of Science, vol. 4(4), pages 1-7, April.
    11. Woodley of Menie, Michael A. & Peñaherrera-Aguirre, Mateo & Sarraf, Matthew A., 2022. "Signs of a Flynn effect in rodents? Secular differentiation of the manifold of general cognitive ability in laboratory mice (Mus musculus) and Norwegian rats (Rattus norvegicus) over a century—Results," Intelligence, Elsevier, vol. 95(C).

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