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Synaptic tagging and long-term potentiation

Author

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  • Uwe Frey

    (Gene Regulation and Plasticity)

  • Richard G. M. Morris

    (Gene Regulation and Plasticity)

Abstract

Repeated stimulation of hippocampal neurons can induce an immediate and prolonged increase in synaptic strength that is called long-term potentiation (LTP)—the primary cellular model of memory in the mammalian brain1. An early phase of LTP (lasting less than three hours) can be dissociated from late-phase LTP by using inhibitors of transcription and translation2–8. Because protein synthesis occurs mainly in the cell body9–12, whereas LTP is input-specific, the question arises of how the synapse specificity of late LTP is achieved without elaborate intracellular protein trafficking. We propose that LTP initiates the creation of a short-lasting protein-synthesis-independent 'synaptic tag' at the potentiated synapse which sequesters the relevant protein(s) to establish late LTP. In support of this idea, we now show that weak tetanic stimulation, which ordinarily leads only to early LTP, or repeated tetanization in the presence of protein-synthesis inhibitors, each results in protein-synthesis-dependent late LTP, provided repeated tetanization has already been applied at another input to the same population of neurons. The synaptic tag decays in less than three hours. These findings indicate that the persistence of LTP depends not only on local events during its induction, but also on the prior activity of the neuron.

Suggested Citation

  • Uwe Frey & Richard G. M. Morris, 1997. "Synaptic tagging and long-term potentiation," Nature, Nature, vol. 385(6616), pages 533-536, February.
  • Handle: RePEc:nat:nature:v:385:y:1997:i:6616:d:10.1038_385533a0
    DOI: 10.1038/385533a0
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    Cited by:

    1. Jaschke Philipp & Sulin Sardoschau & Marco Tabellini, 2021. "Scared Straight? Threat and Assimilation of Refugees in Germany," RF Berlin - CReAM Discussion Paper Series 2136, Rockwool Foundation Berlin (RF Berlin) - Centre for Research and Analysis of Migration (CReAM).
    2. Dekeyser, Simon & He, Xianjie & Xiao, Tusheng & Zuo, Luo, 2024. "Auditor industry range and audit quality," Journal of Accounting and Economics, Elsevier, vol. 77(2).
    3. Philipp Jaschke & Sulin Sardoschau & Marco Tabellini, 2023. "Scared Straight? Threat and Assimilation of Refugees in Germany," Rationality and Competition Discussion Paper Series 384, CRC TRR 190 Rationality and Competition.
    4. Syed Ghazi Sarwat & Timoleon Moraitis & C. David Wright & Harish Bhaskaran, 2022. "Chalcogenide optomemristors for multi-factor neuromorphic computation," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    5. Giuliano, Paola & Spilimbergo, Antonio, 2024. "Aggregate Shocks and the Formation of Preferences and Beliefs," IZA Discussion Papers 17110, Institute of Labor Economics (IZA).
    6. Tatsuya Osaki & Tomoya Duenki & Siu Yu A. Chow & Yasuhiro Ikegami & Romain Beaubois & Timothée Levi & Nao Nakagawa-Tamagawa & Yoji Hirano & Yoshiho Ikeuchi, 2024. "Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    7. Harris E. Blankenship & Kelsey A. Carter & Kevin D. Pham & Nina T. Cassidy & Andrea N. Markiewicz & Michael I. Thellmann & Amanda L. Sharpe & Willard M. Freeman & Michael J. Beckstead, 2024. "VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    8. Douglas Feitosa Tomé & Sadra Sadeh & Claudia Clopath, 2022. "Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    9. Bharanidharan Shanmugasundaram & Yogesh D Aher & Jana Aradska & Marija Ilic & Daniel Daba Feyissa & Predrag Kalaba & Nilima Y Aher & Vladimir Dragacevic & Babak Saber Marouf & Thierry Langer & Harald , 2017. "R-Modafinil exerts weak effects on spatial memory acquisition and dentate gyrus synaptic plasticity," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-17, June.

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