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Cloning of the wheat Yr15 resistance gene sheds light on the plant tandem kinase-pseudokinase family

Author

Listed:
  • Valentina Klymiuk

    (University of Haifa
    University of Haifa)

  • Elitsur Yaniv

    (University of Haifa
    University of Haifa
    University of Helsinki
    University of Helsinki)

  • Lin Huang

    (University of Haifa
    University of Haifa
    Sichuan Agricultural University)

  • Dina Raats

    (University of Haifa
    University of Haifa
    Earlham Institute)

  • Andrii Fatiukha

    (University of Haifa
    University of Haifa)

  • Shisheng Chen

    (University of California)

  • Lihua Feng

    (University of Haifa
    University of Haifa)

  • Zeev Frenkel

    (University of Haifa)

  • Tamar Krugman

    (University of Haifa)

  • Gabriel Lidzbarsky

    (University of Haifa)

  • Wei Chang

    (University of Helsinki
    University of Helsinki)

  • Marko J. Jääskeläinen

    (University of Helsinki
    University of Helsinki)

  • Christian Schudoma

    (Earlham Institute)

  • Lars Paulin

    (University of Helsinki)

  • Pia Laine

    (University of Helsinki)

  • Harbans Bariana

    (The University of Sydney Plant Breeding Institute)

  • Hanan Sela

    (University of Haifa
    Tel Aviv University)

  • Kamran Saleem

    (Aarhus University)

  • Chris Khadgi Sørensen

    (Aarhus University)

  • Mogens S. Hovmøller

    (Aarhus University)

  • Assaf Distelfeld

    (University of Haifa
    Tel Aviv University)

  • Boulos Chalhoub

    (Institute of System and Synthetic Biology—Organization and Evolution of Complex Genomes)

  • Jorge Dubcovsky

    (University of California
    Howard Hughes Medical Institute)

  • Abraham B. Korol

    (University of Haifa
    University of Haifa)

  • Alan H. Schulman

    (University of Helsinki
    University of Helsinki
    Natural Resources Institute Finland (Luke))

  • Tzion Fahima

    (University of Haifa
    University of Haifa)

Abstract

Yellow rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a devastating fungal disease threatening much of global wheat production. Race-specific resistance (R)-genes are used to control rust diseases, but the rapid emergence of virulent Pst races has prompted the search for a more durable resistance. Here, we report the cloning of Yr15, a broad-spectrum R-gene derived from wild emmer wheat, which encodes a putative kinase-pseudokinase protein, designated as wheat tandem kinase 1, comprising a unique R-gene structure in wheat. The existence of a similar gene architecture in 92 putative proteins across the plant kingdom, including the barley RPG1 and a candidate for Ug8, suggests that they are members of a distinct family of plant proteins, termed here tandem kinase-pseudokinases (TKPs). The presence of kinase-pseudokinase structure in both plant TKPs and the animal Janus kinases sheds light on the molecular evolution of immune responses across these two kingdoms.

Suggested Citation

  • Valentina Klymiuk & Elitsur Yaniv & Lin Huang & Dina Raats & Andrii Fatiukha & Shisheng Chen & Lihua Feng & Zeev Frenkel & Tamar Krugman & Gabriel Lidzbarsky & Wei Chang & Marko J. Jääskeläinen & Chri, 2018. "Cloning of the wheat Yr15 resistance gene sheds light on the plant tandem kinase-pseudokinase family," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06138-9
    DOI: 10.1038/s41467-018-06138-9
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    Cited by:

    1. Guotai Yu & Oadi Matny & Nicolas Champouret & Burkhard Steuernagel & Matthew J. Moscou & Inmaculada Hernández-Pinzón & Phon Green & Sadiye Hayta & Mark Smedley & Wendy Harwood & Ngonidzashe Kangara & , 2022. "Aegilops sharonensis genome-assisted identification of stem rust resistance gene Sr62," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Miaomiao Li & Huaizhi Zhang & Huixin Xiao & Keyu Zhu & Wenqi Shi & Dong Zhang & Yong Wang & Lijun Yang & Qiuhong Wu & Jingzhong Xie & Yongxing Chen & Dan Qiu & Guanghao Guo & Ping Lu & Beibei Li & Lei, 2024. "A membrane associated tandem kinase from wild emmer wheat confers broad-spectrum resistance to powdery mildew," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Yue Zhao & Zhenjie Dong & Jingnan Miao & Qianwen Liu & Chao Ma & Xiubin Tian & Jinqiu He & Huihui Bi & Wen Yao & Tao Li & Harsimardeep S. Gill & Zhibin Zhang & Aizhong Cao & Bao Liu & Huanhuan Li & Su, 2024. "Pm57 from Aegilops searsii encodes a tandem kinase protein and confers wheat powdery mildew resistance," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Gengshen Chen & Bao Zhang & Junqiang Ding & Hongze Wang & Ce Deng & Jiali Wang & Qianhui Yang & Qianyu Pi & Ruyang Zhang & Haoyu Zhai & Junfei Dong & Junshi Huang & Jiabao Hou & Junhua Wu & Jiamin Que, 2022. "Cloning southern corn rust resistant gene RppK and its cognate gene AvrRppK from Puccinia polysora," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Huagang He & Zhaozhao Chen & Renchun Fan & Jie Zhang & Shanying Zhu & Jiale Wang & Qianyuan Zhang & Anli Gao & Shuangjun Gong & Lu Zhang & Yanan Li & Yitong Zhao & Simon G. Krattinger & Qian-Hua Shen , 2024. "A kinase fusion protein from Aegilops longissima confers resistance to wheat powdery mildew," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Huanhuan Li & Wenqiang Men & Chao Ma & Qianwen Liu & Zhenjie Dong & Xiubin Tian & Chaoli Wang & Cheng Liu & Harsimardeep S. Gill & Pengtao Ma & Zhibin Zhang & Bao Liu & Yue Zhao & Sunish K. Sehgal & W, 2024. "Wheat powdery mildew resistance gene Pm13 encodes a mixed lineage kinase domain-like protein," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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