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Transgenic Cavendish bananas with resistance to Fusarium wilt tropical race 4

Author

Listed:
  • James Dale

    (Queensland University of Technology)

  • Anthony James

    (Queensland University of Technology)

  • Jean-Yves Paul

    (Queensland University of Technology)

  • Harjeet Khanna

    (Queensland University of Technology
    Sugar Research Australia)

  • Mark Smith

    (Darwin Banana Farming Company)

  • Santy Peraza-Echeverria

    (Queensland University of Technology
    Unidad de Biotecnologia Centro de Investigacion Cientifica de Yucatan)

  • Fernando Garcia-Bastidas

    (Wageningen University and Research Centre, Plant Research International)

  • Gert Kema

    (Wageningen University and Research Centre, Plant Research International)

  • Peter Waterhouse

    (Queensland University of Technology)

  • Kerrie Mengersen

    (Queensland University of Technology)

  • Robert Harding

    (Queensland University of Technology)

Abstract

Banana (Musa spp.) is a staple food for more than 400 million people. Over 40% of world production and virtually all the export trade is based on Cavendish banana. However, Cavendish banana is under threat from a virulent fungus, Fusarium oxysporum f. sp. cubense tropical race 4 (TR4) for which no acceptable resistant replacement has been identified. Here we report the identification of transgenic Cavendish with resistance to TR4. In our 3-year field trial, two lines of transgenic Cavendish, one transformed with RGA2, a gene isolated from a TR4-resistant diploid banana, and the other with a nematode-derived gene, Ced9, remain disease free. Transgene expression in the RGA2 lines is strongly correlated with resistance. Endogenous RGA2 homologs are also present in Cavendish but are expressed tenfold lower than that in our most resistant transgenic line. The expression of these homologs can potentially be elevated through gene editing, to provide non-transgenic resistance.

Suggested Citation

  • James Dale & Anthony James & Jean-Yves Paul & Harjeet Khanna & Mark Smith & Santy Peraza-Echeverria & Fernando Garcia-Bastidas & Gert Kema & Peter Waterhouse & Kerrie Mengersen & Robert Harding, 2017. "Transgenic Cavendish bananas with resistance to Fusarium wilt tropical race 4," Nature Communications, Nature, vol. 8(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01670-6
    DOI: 10.1038/s41467-017-01670-6
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    Cited by:

    1. Andlia Abdoussalami & Zhenghua Hu & Abu Reza Md. Towfiqul Islam & Zhurong Wu, 2023. "Climate change and its impacts on banana production: a systematic analysis," Environment, Development and Sustainability: A Multidisciplinary Approach to the Theory and Practice of Sustainable Development, Springer, vol. 25(11), pages 12217-12246, November.
    2. Carlos F. B. V. Alho & Amanda F. Silva & Chantal M. J. Hendriks & Jetse J. Stoorvogel & Peter J. M. Oosterveer & Eric M. A. Smaling, 2021. "Analysis of banana and cocoa export commodities in food system transformation, with special reference to certification schemes as drivers of change," Food Security: The Science, Sociology and Economics of Food Production and Access to Food, Springer;The International Society for Plant Pathology, vol. 13(6), pages 1555-1575, December.
    3. Alho, Carlos F.B.V. & da Silva, Amanda F. & Hendriks, Chantal M.J. & Stoorvogel, Jetse J. & Oosterveer, Peter J.M. & Smaling, Eric M.A., 2022. "IFAD Research Series 79: The position of export crops banana and cocoa in food systems analysis with special reference to the role of certification schemes," IFAD Research Series 322000, International Fund for Agricultural Development (IFAD).

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