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Lateral orbitofrontal cortex anticipates choices and integrates prior with current information

Author

Listed:
  • Ramon Nogueira

    (Universitat Pompeu Fabra
    Research Unit, Parc Sanitari Sant Joan de Déu, Esplugues de Llobregat)

  • Juan M. Abolafia

    (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))

  • Jan Drugowitsch

    (Université de Genève
    Harvard Medical School)

  • Emili Balaguer-Ballester

    (Faculty of Science and Technology, Bournemouth University
    Bernstein Center for Computational Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University)

  • Maria V. Sanchez-Vives

    (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
    ICREA)

  • Rubén Moreno-Bote

    (Universitat Pompeu Fabra
    Research Unit, Parc Sanitari Sant Joan de Déu, Esplugues de Llobregat
    Serra Húnter Fellow Programme, Universitat Pompeu Fabra)

Abstract

Adaptive behavior requires integrating prior with current information to anticipate upcoming events. Brain structures related to this computation should bring relevant signals from the recent past into the present. Here we report that rats can integrate the most recent prior information with sensory information, thereby improving behavior on a perceptual decision-making task with outcome-dependent past trial history. We find that anticipatory signals in the orbitofrontal cortex about upcoming choice increase over time and are even present before stimulus onset. These neuronal signals also represent the stimulus and relevant second-order combinations of past state variables. The encoding of choice, stimulus and second-order past state variables resides, up to movement onset, in overlapping populations. The neuronal representation of choice before stimulus onset and its build-up once the stimulus is presented suggest that orbitofrontal cortex plays a role in transforming immediate prior and stimulus information into choices using a compact state-space representation.

Suggested Citation

  • Ramon Nogueira & Juan M. Abolafia & Jan Drugowitsch & Emili Balaguer-Ballester & Maria V. Sanchez-Vives & Rubén Moreno-Bote, 2017. "Lateral orbitofrontal cortex anticipates choices and integrates prior with current information," Nature Communications, Nature, vol. 8(1), pages 1-13, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14823
    DOI: 10.1038/ncomms14823
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    Cited by:

    1. Wenyi Zhang & Yang Xie & Tianming Yang, 2022. "Reward salience but not spatial attention dominates the value representation in the orbitofrontal cortex," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Huixin Lin & Jingfeng Zhou, 2024. "Hippocampal and orbitofrontal neurons contribute to complementary aspects of associative structure," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Demetrio Ferro & Tyler Cash-Padgett & Maya Zhe Wang & Benjamin Y. Hayden & Rubén Moreno-Bote, 2024. "Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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