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Membrane tension and peripheral protein density mediate membrane shape transitions

Author

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  • Zheng Shi

    (University of Pennsylvania)

  • Tobias Baumgart

    (University of Pennsylvania)

Abstract

Endocytosis is a ubiquitous eukaryotic membrane budding, vesiculation and internalization process fulfilling numerous roles including compensation of membrane area increase after bursts of exocytosis. The mechanism of the coupling between these two processes to enable homeostasis is not well understood. Recently, an ultrafast endocytosis (UFE) pathway was revealed with a speed significantly exceeding classical clathrin-mediated endocytosis (CME). Membrane tension reduction is a potential mechanism by which endocytosis can be rapidly activated at remote sites. Here, we provide experimental evidence for a mechanism whereby membrane tension reduction initiates membrane budding and tubulation mediated by endocytic proteins, such as endophilin A1. We find that shape instabilities occur at well-defined membrane tensions and surface densities of endophilin. From our data, we obtain a membrane shape stability diagram that shows remarkable consistency with a quantitative model. This model applies to all laterally diffusive curvature-coupling proteins and therefore a wide range of endocytic proteins.

Suggested Citation

  • Zheng Shi & Tobias Baumgart, 2015. "Membrane tension and peripheral protein density mediate membrane shape transitions," Nature Communications, Nature, vol. 6(1), pages 1-8, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6974
    DOI: 10.1038/ncomms6974
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    Cited by:

    1. Shilong Yang & Xinwen Miao & Steven Arnold & Boxuan Li & Alan T. Ly & Huan Wang & Matthew Wang & Xiangfu Guo & Medha M. Pathak & Wenting Zhao & Charles D. Cox & Zheng Shi, 2022. "Membrane curvature governs the distribution of Piezo1 in live cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Anabel-Lise Le Roux & Caterina Tozzi & Nikhil Walani & Xarxa Quiroga & Dobryna Zalvidea & Xavier Trepat & Margarita Staykova & Marino Arroyo & Pere Roca-Cusachs, 2021. "Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Kazuya Tsujita & Reiko Satow & Shinobu Asada & Yoshikazu Nakamura & Luis Arnes & Keisuke Sako & Yasuyuki Fujita & Kiyoko Fukami & Toshiki Itoh, 2021. "Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    4. Tyler H. Ogunmowo & Haoyuan Jing & Sumana Raychaudhuri & Grant F. Kusick & Yuuta Imoto & Shuo Li & Kie Itoh & Ye Ma & Haani Jafri & Matthew B. Dalva & Edwin R. Chapman & Taekjip Ha & Shigeki Watanabe , 2023. "Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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