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Sox17 is indispensable for acquisition and maintenance of arterial identity

Author

Listed:
  • Monica Corada

    (FIRC Institute of Molecular Oncology (IFOM))

  • Fabrizio Orsenigo

    (FIRC Institute of Molecular Oncology (IFOM))

  • Marco Francesco Morini

    (FIRC Institute of Molecular Oncology (IFOM))

  • Mara Elena Pitulescu

    (Max Planck Institute for Molecular Biomedicine and Faculty of Medicine, University of Münster)

  • Ganesh Bhat

    (FIRC Institute of Molecular Oncology (IFOM))

  • Daniel Nyqvist

    (Karolinska Institutet)

  • Ferruccio Breviario

    (FIRC Institute of Molecular Oncology (IFOM))

  • Valentina Conti

    (Stem Cells and Gene Therapy DIBIT H San Raffaele)

  • Anais Briot

    (Cell and Developmental Biology, University of California)

  • M. Luisa Iruela-Arispe

    (Cell and Developmental Biology, University of California)

  • Ralf H. Adams

    (Max Planck Institute for Molecular Biomedicine and Faculty of Medicine, University of Münster)

  • Elisabetta Dejana

    (FIRC Institute of Molecular Oncology (IFOM)
    School of Sciences, University of Milan)

Abstract

The functional diversity of the arterial and venous endothelia is regulated through a complex system of signalling pathways and downstream transcription factors. Here we report that the transcription factor Sox17, which is known as a regulator of endoderm and hemopoietic differentiation, is selectively expressed in arteries, and not in veins, in the mouse embryo and in mouse postnatal retina and adult. Endothelial cell-specific inactivation of Sox17 in the mouse embryo is accompanied by a lack of arterial differentiation and vascular remodelling that results in embryo death in utero. In mouse postnatal retina, abrogation of Sox17 expression in endothelial cells leads to strong vascular hypersprouting, loss of arterial identity and large arteriovenous malformations. Mechanistically, Sox17 acts upstream of the Notch system and downstream of the canonical Wnt system. These data introduce Sox17 as a component of the complex signalling network that orchestrates arterial/venous specification.

Suggested Citation

  • Monica Corada & Fabrizio Orsenigo & Marco Francesco Morini & Mara Elena Pitulescu & Ganesh Bhat & Daniel Nyqvist & Ferruccio Breviario & Valentina Conti & Anais Briot & M. Luisa Iruela-Arispe & Ralf H, 2013. "Sox17 is indispensable for acquisition and maintenance of arterial identity," Nature Communications, Nature, vol. 4(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3609
    DOI: 10.1038/ncomms3609
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    Cited by:

    1. Jonas Stewen & Kai Kruse & Anca T. Godoi-Filip & Zenia & Hyun-Woo Jeong & Susanne Adams & Frank Berkenfeld & Martin Stehling & Kristy Red-Horse & Ralf H. Adams & Mara E. Pitulescu, 2024. "Eph-ephrin signaling couples endothelial cell sorting and arterial specification," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    2. Kathryn Weinand & Saori Sakaue & Aparna Nathan & Anna Helena Jonsson & Fan Zhang & Gerald F. M. Watts & Majd Al Suqri & Zhu Zhu & Deepak A. Rao & Jennifer H. Anolik & Michael B. Brenner & Laura T. Don, 2024. "The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis," Nature Communications, Nature, vol. 15(1), pages 1-25, December.
    3. Pengfei Lu & Ping Wang & Bingruo Wu & Yidong Wang & Yang Liu & Wei Cheng & Xuhui Feng & Xinchun Yuan & Miriam M. Atteya & Haleigh Ferro & Yukiko Sugi & Grant Rydquist & Mahdi Esmaily & Jonathan T. But, 2022. "A SOX17-PDGFB signaling axis regulates aortic root development," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Nicholas W. Chavkin & Gael Genet & Mathilde Poulet & Erin D. Jeffery & Corina Marziano & Nafiisha Genet & Hema Vasavada & Elizabeth A. Nelson & Bipul R. Acharya & Anupreet Kour & Jordon Aragon & Steph, 2022. "Endothelial cell cycle state determines propensity for arterial-venous fate," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    5. Brandon Hadland & Barbara Varnum-Finney & Stacey Dozono & Tessa Dignum & Cynthia Nourigat-McKay & Adam M. Heck & Takashi Ishida & Dana L. Jackson & Tomer Itkin & Jason M. Butler & Shahin Rafii & Cole , 2022. "Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Aya Uchida & Kenya Imaimatsu & Honoka Suzuki & Xiao Han & Hiroki Ushioda & Mami Uemura & Kasane Imura-Kishi & Ryuji Hiramatsu & Hinako M. Takase & Yoshikazu Hirate & Atsuo Ogura & Masami Kanai-Azuma &, 2022. "SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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