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SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse

Author

Listed:
  • Aya Uchida

    (The University of Tokyo
    Bioresource Engineering Division, RIKEN BioResouce Research Center)

  • Kenya Imaimatsu

    (The University of Tokyo)

  • Honoka Suzuki

    (The University of Tokyo)

  • Xiao Han

    (The University of Tokyo)

  • Hiroki Ushioda

    (The University of Tokyo)

  • Mami Uemura

    (The University of Tokyo)

  • Kasane Imura-Kishi

    (The University of Tokyo)

  • Ryuji Hiramatsu

    (The University of Tokyo)

  • Hinako M. Takase

    (Tokyo Medical and Dental University)

  • Yoshikazu Hirate

    (Tokyo Medical and Dental University)

  • Atsuo Ogura

    (Bioresource Engineering Division, RIKEN BioResouce Research Center)

  • Masami Kanai-Azuma

    (Tokyo Medical and Dental University)

  • Akihiko Kudo

    (Kyorin University School of Medicine)

  • Yoshiakira Kanai

    (The University of Tokyo)

Abstract

Seminiferous tubules (STs) in the mammalian testes are connected to the rete testis (RT) via a Sertoli valve (SV). Spermatozoa produced in the STs are released into the tubular luminal fluid and passively transported through the SV into the RT. However, the physiological functions of the RT and SV remain unclear. Here, we identified the expression of Sox17 in RT epithelia. The SV valve was disrupted before puberty in RT-specific Sox17 conditional knockout (Sox17-cKO) male mice. This induced a backflow of RT fluid into the STs, which caused aberrant detachment of immature spermatids. RT of Sox17-cKO mice had reduced expression levels of various growth factor genes, which presumably support SV formation. When transplanted next to the Sox17+ RT, Sertoli cells of Sox17-cKO mice reconstructed the SV and supported proper spermiogenesis in the STs. This study highlights the novel and unexpected modulatory roles of the RT in SV valve formation and spermatogenesis in mouse testes, as a downstream action of Sox17.

Suggested Citation

  • Aya Uchida & Kenya Imaimatsu & Honoka Suzuki & Xiao Han & Hiroki Ushioda & Mami Uemura & Kasane Imura-Kishi & Ryuji Hiramatsu & Hinako M. Takase & Yoshikazu Hirate & Atsuo Ogura & Masami Kanai-Azuma &, 2022. "SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35465-1
    DOI: 10.1038/s41467-022-35465-1
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    References listed on IDEAS

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    1. Pengfei Lu & Ping Wang & Bingruo Wu & Yidong Wang & Yang Liu & Wei Cheng & Xuhui Feng & Xinchun Yuan & Miriam M. Atteya & Haleigh Ferro & Yukiko Sugi & Grant Rydquist & Mahdi Esmaily & Jonathan T. But, 2022. "A SOX17-PDGFB signaling axis regulates aortic root development," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Monica Corada & Fabrizio Orsenigo & Marco Francesco Morini & Mara Elena Pitulescu & Ganesh Bhat & Daniel Nyqvist & Ferruccio Breviario & Valentina Conti & Anais Briot & M. Luisa Iruela-Arispe & Ralf H, 2013. "Sox17 is indispensable for acquisition and maintenance of arterial identity," Nature Communications, Nature, vol. 4(1), pages 1-14, December.
    3. Menglin Liu & Lianghui Zhang & Glenn Marsboom & Ankit Jambusaria & Shiqin Xiong & Peter T. Toth & Elizaveta V. Benevolenskaya & Jalees Rehman & Asrar B. Malik, 2019. "Sox17 is required for endothelial regeneration following inflammation-induced vascular injury," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
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