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On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

Author

Listed:
  • Esther Krook-Magnuson

    (University of California)

  • Caren Armstrong

    (University of California)

  • Mikko Oijala

    (University of California)

  • Ivan Soltesz

    (University of California)

Abstract

Temporal lobe epilepsy is the most common type of epilepsy in adults, is often medically refractory, and due to broad actions and long-time scales, current systemic treatments have major negative side-effects. However, temporal lobe seizures tend to arise from discrete regions before overt clinical behaviour, making temporally and spatially specific treatment theoretically possible. Here we report the arrest of spontaneous seizures using a real-time, closed-loop, response system and in vivo optogenetics in a mouse model of temporal lobe epilepsy. Either optogenetic inhibition of excitatory principal cells, or activation of a subpopulation of GABAergic cells representing

Suggested Citation

  • Esther Krook-Magnuson & Caren Armstrong & Mikko Oijala & Ivan Soltesz, 2013. "On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy," Nature Communications, Nature, vol. 4(1), pages 1-8, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2376
    DOI: 10.1038/ncomms2376
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    Cited by:

    1. Wonok Kang & Chanyang Ju & Jaesoon Joo & Jiho Lee & Young-Min Shon & Sung-Min Park, 2022. "Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Assunta Merolla & Caterina Michetti & Matteo Moschetta & Francesca Vacca & Lorenzo Ciano & Laura Emionite & Simonetta Astigiano & Alessandra Romei & Simone Horenkamp & Ken Berglund & Robert E. Gross &, 2024. "A pH-sensitive closed-loop nanomachine to control hyperexcitability at the single neuron level," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    3. John-Sebastian Mueller & Fabio C. Tescarollo & Trong Huynh & Daniel A. Brenner & Daniel J. Valdivia & Kanyin Olagbegi & Sahana Sangappa & Spencer C. Chen & Hai Sun, 2023. "Ictogenesis proceeds through discrete phases in hippocampal CA1 seizures in mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. James Okoh & Jacqunae Mays & Alexandre Bacq & Juan A. Oses-Prieto & Stefka Tyanova & Chien-Ju Chen & Khalel Imanbeyev & Marion Doladilhe & Hongyi Zhou & Paymaan Jafar-Nejad & Alma Burlingame & Jeffrey, 2023. "Targeted suppression of mTORC2 reduces seizures across models of epilepsy," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Quynh-Anh Nguyen & Peter M. Klein & Cheng Xie & Katelyn N. Benthall & Jillian Iafrati & Jesslyn Homidan & Jacob T. Bendor & Barna Dudok & Jordan S. Farrell & Tilo Gschwind & Charlotte L. Porter & Anna, 2024. "Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Zhao, Jinyi & Yu, Ying & Wang, Qingyun, 2022. "Dynamical regulation of epileptiform discharges caused by abnormal astrocyte function with optogenetic stimulation," Chaos, Solitons & Fractals, Elsevier, vol. 164(C).
    7. Jung Ho Hyun & Kenichiro Nagahama & Ho Namkung & Neymi Mignocchi & Seung-Eon Roh & Patrick Hannan & Sarah Krüssel & Chuljung Kwak & Abigail McElroy & Bian Liu & Mingguang Cui & Seunghwan Lee & Dongmin, 2022. "Tagging active neurons by soma-targeted Cal-Light," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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