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Exploiting multimode waveguides for pure fibre-based imaging

Author

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  • Tomáš Čižmár

    (School of Medicine, University of St. Andrews, North Haugh, St. Andrews KY16 9TF, UK.)

  • Kishan Dholakia

    (SUPA, School of Physics and Astronomy, University of St. Andrews, North Haugh, St. Andrews KY16 9SS, UK.)

Abstract

There has been an immense drive in modern microscopy towards miniaturization and fibre-based technology. This has been necessitated by the need to access hostile or difficult environments in situ and in vivo. Strategies to date have included the use of specialist fibres and miniaturized scanning systems accompanied by ingenious microfabricated lenses. Here we present a novel approach for this field by utilizing disordered light within a standard multimode optical fibre for lensless microscopy and optical mode conversion. We demonstrate the modalities of bright- and dark-field imaging and scanning fluorescence microscopy at acquisition rates that allow observation of dynamic processes such as Brownian motion of mesoscopic particles. Furthermore, we show how such control can realize a new form of mode converter and generate various types of advanced light fields such as propagation-invariant beams and optical vortices. These may be useful for future fibre-based implementations of super-resolution or light-sheet microscopy.

Suggested Citation

  • Tomáš Čižmár & Kishan Dholakia, 2012. "Exploiting multimode waveguides for pure fibre-based imaging," Nature Communications, Nature, vol. 3(1), pages 1-9, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms2024
    DOI: 10.1038/ncomms2024
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    Cited by:

    1. Wonjun Choi & Munkyu Kang & Jin Hee Hong & Ori Katz & Byunghak Lee & Guang Hoon Kim & Youngwoon Choi & Wonshik Choi, 2022. "Flexible-type ultrathin holographic endoscope for microscopic imaging of unstained biological tissues," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Miroslav Stibůrek & Petra Ondráčková & Tereza Tučková & Sergey Turtaev & Martin Šiler & Tomáš Pikálek & Petr Jákl & André Gomes & Jana Krejčí & Petra Kolbábková & Hana Uhlířová & Tomáš Čižmár, 2023. "110 μm thin endo-microscope for deep-brain in vivo observations of neuronal connectivity, activity and blood flow dynamics," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    3. Ziwei Li & Wei Zhou & Zhanhong Zhou & Shuqi Zhang & Jianyang Shi & Chao Shen & Junwen Zhang & Nan Chi & Qionghai Dai, 2024. "Self-supervised dynamic learning for long-term high-fidelity image transmission through unstabilized diffusive media," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    4. Noam Badt & Ori Katz, 2022. "Real-time holographic lensless micro-endoscopy through flexible fibers via fiber bundle distal holography," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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