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Real-time holographic lensless micro-endoscopy through flexible fibers via fiber bundle distal holography

Author

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  • Noam Badt

    (The Hebrew University of Jerusalem)

  • Ori Katz

    (The Hebrew University of Jerusalem)

Abstract

Fiber-based micro-endoscopes are a critically important tool for minimally-invasive deep-tissue imaging. However, current micro-endoscopes cannot perform three-dimensional imaging through dynamically-bent fibers without the use of bulky optical elements such as lenses and scanners at the distal end, increasing the footprint and tissue-damage. Great efforts have been invested in developing approaches that avoid distal bulky optical elements. However, the fundamental barrier of dynamic optical wavefront-distortions in propagation through flexible fibers limits current approaches to nearly-static or non-flexible fibers. Here, we present an approach that allows holographic, bend-insensitive, coherence-gated, micro-endoscopic imaging using commercially available multi-core fibers (MCFs). We achieve this by adding a partially-reflecting mirror to the distal fiber-tip, allowing to perform low-coherence full-field phase-shifting holography. We demonstrate widefield diffraction-limited reflection imaging of amplitude and phase targets through dynamically bent fibers at video-rate. Our approach holds potential for label-free investigations of dynamic samples.

Suggested Citation

  • Noam Badt & Ori Katz, 2022. "Real-time holographic lensless micro-endoscopy through flexible fibers via fiber bundle distal holography," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33462-y
    DOI: 10.1038/s41467-022-33462-y
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    References listed on IDEAS

    as
    1. Tomáš Čižmár & Kishan Dholakia, 2012. "Exploiting multimode waveguides for pure fibre-based imaging," Nature Communications, Nature, vol. 3(1), pages 1-9, January.
    2. Roman Barankov & Jerome Mertz, 2014. "High-throughput imaging of self-luminous objects through a single optical fibre," Nature Communications, Nature, vol. 5(1), pages 1-6, December.
    3. Shuhui Li & Simon A. R. Horsley & Tomáš Tyc & Tomáš Čižmár & David B. Phillips, 2021. "Memory effect assisted imaging through multimode optical fibres," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
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