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Keratinocyte-driven dermal collagen formation in the axolotl skin

Author

Listed:
  • Ayaka Ohashi

    (3-1-1 Tsushima-naka)

  • Hirotaka Sakamoto

    (3-1-1 Tsushima-naka)

  • Junpei Kuroda

    (Suita)

  • Yohei Kondo

    (Showa-ku)

  • Yasuhiro Kamei

    (Myodaiji Nishigo-naka 38
    Myodaiji Nishigo-naka 38
    Myodaiji Nishigo-naka 38)

  • Shigenori Nonaka

    (Myodaiji Nishigo-naka 38
    Myodaiji Nishigo-naka 38
    Myodaiji Nishigo-naka 38
    Myodaiji Nishigo-naka 38)

  • Saya Furukawa

    (3-1-1 Tsushima-naka)

  • Sakiya Yamamoto

    (3-1-1 Tsushima-naka)

  • Akira Satoh

    (3-1-1 Tsushima-naka)

Abstract

Type I collagen is a major component of the dermis and is formed by dermal fibroblasts. The development of dermal collagen structures has not been fully elucidated despite the major presence and importance of the dermis. This lack of understanding is due in part to the opacity of mammalian skin and it has been an obstacle to cosmetic and medical developments. We reveal the process of dermal collagen formation using the highly transparent skin of the axolotl and fluorescent collagen probes. We clarify that epidermal cells, not dermal fibroblasts, contribute to dermal collagen formation. Mesenchymal cells (fibroblasts) play a role in modifying the collagen fibers already built by keratinocytes. We confirm that collagen production by keratinocytes is a widely conserved mechanism in other model organisms. Our findings warrant a change in the current consensus about dermal collagen formation and could lead to innovations in cosmetology and skin medication.

Suggested Citation

  • Ayaka Ohashi & Hirotaka Sakamoto & Junpei Kuroda & Yohei Kondo & Yasuhiro Kamei & Shigenori Nonaka & Saya Furukawa & Sakiya Yamamoto & Akira Satoh, 2025. "Keratinocyte-driven dermal collagen formation in the axolotl skin," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57055-7
    DOI: 10.1038/s41467-025-57055-7
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    References listed on IDEAS

    as
    1. Christos Kyprianou & Neophytos Christodoulou & Russell S. Hamilton & Wallis Nahaboo & Diana Suarez Boomgaard & Gianluca Amadei & Isabelle Migeotte & Magdalena Zernicka-Goetz, 2020. "Basement membrane remodelling regulates mouse embryogenesis," Nature, Nature, vol. 582(7811), pages 253-258, June.
    2. Kazumasa Mitogawa & Aki Makanae & Ayano Satoh & Akira Satoh, 2015. "Comparative Analysis of Cartilage Marker Gene Expression Patterns during Axolotl and Xenopus Limb Regeneration," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-18, July.
    3. Feiyang Ma & Olesya Plazyo & Allison C. Billi & Lam C. Tsoi & Xianying Xing & Rachael Wasikowski & Mehrnaz Gharaee-Kermani & Grace Hile & Yanyun Jiang & Paul W. Harms & Enze Xing & Joseph Kirma & Jing, 2023. "Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
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