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Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy

Author

Listed:
  • Sang‑Hyuk Jung

    (University of Pennsylvania)

  • Haemin Kim

    (Seoul National University College of Medicine
    School of Medicine)

  • Young Mi Jung

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Manu Shivakumar

    (University of Pennsylvania)

  • Brenda Xiao

    (University of Pennsylvania)

  • Jaeyoung Kim

    (Samsung Medical Center)

  • Beomjin Jang

    (Samsung Medical Center)

  • Jae-Seung Yun

    (The Catholic University of Korea)

  • Hong-Hee Won

    (Samsung Medical Center)

  • Chan-Wook Park

    (Seoul National University College of Medicine)

  • Joong Shin Park

    (Seoul National University College of Medicine)

  • Jong Kwan Jun

    (Seoul National University College of Medicine)

  • Dokyoon Kim

    (University of Pennsylvania
    University of Pennsylvania)

  • Seung Mi Lee

    (Seoul National University College of Medicine
    Seoul National University Hospital
    Seoul National University)

Abstract

The genetic risk for hypertensive disorders of pregnancy is linked with the development of atherosclerotic cardiovascular disease. However, the effects of lifestyle and metabolic syndrome on atherosclerotic cardiovascular disease have not been evaluated. Here, we assess the long-term association between these factors and atherosclerotic cardiovascular disease in women with genetic risk for hypertensive disorders of pregnancy. We evaluate the genetic risk for hypertensive disorders of pregnancy using a genome-wide polygenic risk score derived from a large-scale GWAS. The incidence of atherosclerotic cardiovascular disease is evaluated according to genetic risk, lifestyle, and metabolic syndrome. Individuals with a very high genetic risk for hypertensive disorders of pregnancy have a 53.0% higher chance of developing atherosclerotic cardiovascular disease than those with a low genetic risk. However, the risk of developing atherosclerotic cardiovascular disease is reduced by up to 64.6% through the maintenance of an ideal metabolic syndrome status and a healthy lifestyle in the high genetic risk group (top 20%), and by up to 65.4% in the low genetic risk group (bottom 20%). These findings emphasize that maintaining a healthy lifestyle in women is equally effective at reducing the risk of atherosclerotic cardiovascular disease independent of genetic risk for hypertensive disorders of pregnancy.

Suggested Citation

  • Sang‑Hyuk Jung & Haemin Kim & Young Mi Jung & Manu Shivakumar & Brenda Xiao & Jaeyoung Kim & Beomjin Jang & Jae-Seung Yun & Hong-Hee Won & Chan-Wook Park & Joong Shin Park & Jong Kwan Jun & Dokyoon Ki, 2025. "Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56107-2
    DOI: 10.1038/s41467-025-56107-2
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