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FinnGen provides genetic insights from a well-phenotyped isolated population

Author

Listed:
  • Mitja I. Kurki

    (University of Helsinki
    Broad Institute of Harvard and MIT
    Broad Institute of Harvard and MIT
    Massachusetts General Hospital)

  • Juha Karjalainen

    (University of Helsinki
    Broad Institute of Harvard and MIT
    Broad Institute of Harvard and MIT
    Massachusetts General Hospital)

  • Priit Palta

    (University of Helsinki
    University of Tartu)

  • Timo P. Sipilä

    (University of Helsinki)

  • Kati Kristiansson

    (Finnish Institute for Health and Welfare (THL))

  • Kati M. Donner

    (University of Helsinki)

  • Mary P. Reeve

    (University of Helsinki)

  • Hannele Laivuori

    (University of Helsinki
    University of Helsinki and Helsinki University Hospital
    Tampere University Hospital
    University of Tampere)

  • Mervi Aavikko

    (University of Helsinki)

  • Mari A. Kaunisto

    (University of Helsinki)

  • Anu Loukola

    (University of Helsinki and Hospital District of Helsinki and Uusimaa)

  • Elisa Lahtela

    (University of Helsinki)

  • Hannele Mattsson

    (Finnish Institute for Health and Welfare (THL))

  • Päivi Laiho

    (Finnish Institute for Health and Welfare (THL))

  • Pietro Della Briotta Parolo

    (University of Helsinki)

  • Arto A. Lehisto

    (University of Helsinki)

  • Masahiro Kanai

    (University of Helsinki
    Broad Institute of Harvard and MIT
    Broad Institute of Harvard and MIT
    Massachusetts General Hospital)

  • Nina Mars

    (University of Helsinki)

  • Joel Rämö

    (University of Helsinki)

  • Tuomo Kiiskinen

    (University of Helsinki)

  • Henrike O. Heyne

    (University of Helsinki
    Broad Institute of Harvard and MIT
    Broad Institute of Harvard and MIT
    University of Potsdam Potsdam)

  • Kumar Veerapen

    (University of Helsinki
    Broad Institute of Harvard and MIT
    Broad Institute of Harvard and MIT
    Massachusetts General Hospital)

  • Sina Rüeger

    (University of Helsinki)

  • Susanna Lemmelä

    (University of Helsinki
    Finnish Institute for Health and Welfare (THL))

  • Wei Zhou

    (Broad Institute of Harvard and MIT
    Broad Institute of Harvard and MIT
    Massachusetts General Hospital)

  • Sanni Ruotsalainen

    (University of Helsinki)

  • Kalle Pärn

    (University of Helsinki)

  • Tero Hiekkalinna

    (Finnish Institute for Health and Welfare (THL))

  • Sami Koskelainen

    (Finnish Institute for Health and Welfare (THL))

  • Teemu Paajanen

    (Finnish Institute for Health and Welfare (THL))

  • Vincent Llorens

    (University of Helsinki)

  • Javier Gracia-Tabuenca

    (Tampere University)

  • Harri Siirtola

    (Tampere University)

  • Kadri Reis

    (University of Tartu)

  • Abdelrahman G. Elnahas

    (University of Tartu)

  • Benjamin Sun

    (Biogen
    University of Cambridge)

  • Christopher N. Foley

    (Optima Partners
    University of Cambridge)

  • Katriina Aalto-Setälä

    (Tampere University)

  • Kaur Alasoo

    (University of Tartu)

  • Mikko Arvas

    (Finnish Red Cross Blood Service)

  • Kirsi Auro

    (GlaxoSmithKline)

  • Shameek Biswas

    (Bristol Myers Squibb)

  • Argyro Bizaki-Vallaskangas

    (Tampere University Hospital and Tampere University)

  • Olli Carpen

    (University of Helsinki and Hospital District of Helsinki and Uusimaa)

  • Chia-Yen Chen

    (Biogen)

  • Oluwaseun A. Dada

    (University of Helsinki)

  • Zhihao Ding

    (Boehringer Ingelheim)

  • Margaret G. Ehm

    (GlaxoSmithKline)

  • Kari Eklund

    (Helsinki University Central Hospital
    Orton Orthopedic Hospital)

  • Martti Färkkilä

    (Helsinki University Hospital, Helsinki University)

  • Hilary Finucane

    (Broad Institute of Harvard and MIT
    Broad Institute of Harvard and MIT
    Massachusetts General Hospital)

  • Andrea Ganna

    (University of Helsinki
    Broad Institute of Harvard and MIT
    Broad Institute of Harvard and MIT
    Massachusetts General Hospital)

  • Awaisa Ghazal

    (University of Helsinki)

  • Robert R. Graham

    (Maze Therapeutics)

  • Eric M. Green

    (Maze Therapeutics)

  • Antti Hakanen

    (University of Turku and Turku University Hospital)

  • Marco Hautalahti

    (Finnish Biobank Cooperative)

  • Åsa K. Hedman

    (Pfizer
    Karolinska Institute)

  • Mikko Hiltunen

    (Tampere University and Tampere University Hospital)

  • Reetta Hinttala

    (University of Oulu
    University of Oulu
    Oulu University Hospital)

  • Iiris Hovatta

    (University of Helsinki
    University of Helsinki)

  • Xinli Hu

    (Pfizer)

  • Adriana Huertas-Vazquez

    (Merck & Co)

  • Laura Huilaja

    (University of Oulu
    Oulu University Hospital)

  • Julie Hunkapiller

    (Genentech)

  • Howard Jacob

    (AbbVie)

  • Jan-Nygaard Jensen

    (Boehringer Ingelheim)

  • Heikki Joensuu

    (Helsinki University Hospital and University of Helsinki)

  • Sally John

    (Biogen)

  • Valtteri Julkunen

    (Kuopio University Hospital
    University of Eastern Finland)

  • Marc Jung

    (Boehringer Ingelheim)

  • Juhani Junttila

    (University of Oulu, Northern Ostrobothnia Hospital District)

  • Kai Kaarniranta

    (Kuopio University Hospital
    University of Eastern Finland)

  • Mika Kähönen

    (Tampere University
    Tampere University Hospital)

  • Risto Kajanne

    (University of Helsinki)

  • Lila Kallio

    (University of Turku and Turku University Hospital)

  • Reetta Kälviäinen

    (Kuopio University Hospital
    University of Eastern Finland)

  • Jaakko Kaprio

    (University of Helsinki
    University of Helsinki)

  • Nurlan Kerimov

    (University of Tartu)

  • Johannes Kettunen

    (Finnish Institute for Health and Welfare (THL)
    University of Oulu
    University of Oulu)

  • Elina Kilpeläinen

    (University of Helsinki)

  • Terhi Kilpi

    (Finnish Institute for Health and Welfare (THL))

  • Katherine Klinger

    (Sanofi R&D)

  • Veli-Matti Kosma

    (University of Eastern Finland
    Kuopio University Hospital)

  • Teijo Kuopio

    (Central Finland Health Care District)

  • Venla Kurra

    (Tampere University Hospital
    Faculty of Medicine and Health Technology)

  • Triin Laisk

    (University of Tartu)

  • Jari Laukkanen

    (Central Finland Health Care District
    University of Eastern Finland)

  • Nathan Lawless

    (Boehringer Ingelheim)

  • Aoxing Liu

    (University of Helsinki)

  • Simonne Longerich

    (Merck & Co)

  • Reedik Mägi

    (University of Tartu)

  • Johanna Mäkelä

    (Finnish Biobank Cooperative)

  • Antti Mäkitie

    (University of Helsinki
    Helsinki University Hospital)

  • Anders Malarstig

    (Pfizer
    Karolinska Institute)

  • Arto Mannermaa

    (University of Eastern Finland
    Kuopio University Hospital)

  • Joseph Maranville

    (Bristol Myers Squibb)

  • Athena Matakidou

    (AstraZeneca)

  • Tuomo Meretoja

    (Helsinki University Hospital and University of Helsinki)

  • Sahar V. Mozaffari

    (Maze Therapeutics)

  • Mari E. K. Niemi

    (University of Helsinki)

  • Marianna Niemi

    (Tampere University
    TAUCHI Research Center & Faculty of Medicine and Health Technology, Tampere University)

  • Teemu Niiranen

    (Finnish Institute for Health and Welfare (THL)
    Turku University Hospital and University of Turku)

  • Christopher J. O´Donnell

    (Novartis Institutes for BioMedical Research)

  • Ma´en Obeidat

    (Novartis Institutes for BioMedical Research)

  • George Okafo

    (Boehringer Ingelheim)

  • Hanna M. Ollila

    (University of Helsinki
    Massachusetts General Hospital)

  • Antti Palomäki

    (Turku University Hospital and University of Turku)

  • Tuula Palotie

    (Helsinki University Hospital
    University of Helsinki)

  • Jukka Partanen

    (Finnish Red Cross Blood Service
    Finnish Hematological Biobank)

  • Dirk S. Paul

    (AstraZeneca)

  • Margit Pelkonen

    (Kuopio University Hospital)

  • Rion K. Pendergrass

    (Genentech)

  • Slavé Petrovski

    (AstraZeneca)

  • Anne Pitkäranta

    (Helsinki University Hospital and University of Helsinki)

  • Adam Platt

    (AstraZeneca)

  • David Pulford

    (GlaxoSmithKline)

  • Eero Punkka

    (University of Helsinki and Hospital District of Helsinki and Uusimaa)

  • Pirkko Pussinen

    (University of Helsinki)

  • Neha Raghavan

    (Merck & Co)

  • Fedik Rahimov

    (AbbVie)

  • Deepak Rajpal

    (Sanofi R&D)

  • Nicole A. Renaud

    (Novartis Institutes for BioMedical Research)

  • Bridget Riley-Gillis

    (AbbVie)

  • Rodosthenis Rodosthenous

    (University of Helsinki)

  • Elmo Saarentaus

    (University of Helsinki)

  • Aino Salminen

    (University of Helsinki)

  • Eveliina Salminen

    (Helsinki University Hospital
    University of Helsinki)

  • Veikko Salomaa

    (Finnish Institute for Health and Welfare (THL))

  • Johanna Schleutker

    (University of Turku and Turku University Hospital)

  • Raisa Serpi

    (University of Oulu, Northern Ostrobothnia Hospital District)

  • Huei-yi Shen

    (University of Helsinki)

  • Richard Siegel

    (Novartis Institutes for BioMedical Research)

  • Kaisa Silander

    (Finnish Institute for Health and Welfare (THL))

  • Sanna Siltanen

    (Tampere University and Tampere University Hospital)

  • Sirpa Soini

    (Finnish Institute for Health and Welfare (THL))

  • Hilkka Soininen

    (University of Eastern Finland)

  • Jae Hoon Sul

    (Merck & Co)

  • Ioanna Tachmazidou

    (AstraZeneca)

  • Kaisa Tasanen

    (University of Oulu
    Oulu University Hospital)

  • Pentti Tienari

    (Helsinki University Hospital
    University of Helsinki)

  • Sanna Toppila-Salmi

    (Helsinki University Hospital and University of Helsinki)

  • Taru Tukiainen

    (University of Helsinki)

  • Tiinamaija Tuomi

    (University of Helsinki
    Helsinki University Hospital
    Folkhalsan Research Center
    University of Helsinki)

  • Joni A. Turunen

    (Helsinki University Hospital and University of Helsinki
    Folkhälsan Research Center)

  • Jacob C. Ulirsch

    (Broad Institute of Harvard and MIT
    Broad Institute of Harvard and MIT)

  • Felix Vaura

    (Finnish Institute for Health and Welfare (THL)
    University of Turku)

  • Petri Virolainen

    (University of Turku and Turku University Hospital)

  • Jeffrey Waring

    (AbbVie)

  • Dawn Waterworth

    (Janssen Research & Development)

  • Robert Yang

    (Janssen Biotech)

  • Mari Nelis

    (University of Tartu)

  • Anu Reigo

    (University of Tartu)

  • Andres Metspalu

    (University of Tartu)

  • Lili Milani

    (University of Tartu)

  • Tõnu Esko

    (University of Tartu)

  • Caroline Fox

    (Merck & Co)

  • Aki S. Havulinna

    (University of Helsinki
    Finnish Institute for Health and Welfare (THL))

  • Markus Perola

    (Finnish Institute for Health and Welfare (THL))

  • Samuli Ripatti

    (University of Helsinki)

  • Anu Jalanko

    (University of Helsinki)

  • Tarja Laitinen

    (Tampere University and Tampere University Hospital)

  • Tomi P. Mäkelä

    (University of Helsinki)

  • Robert Plenge

    (Bristol Myers Squibb)

  • Mark McCarthy

    (Genentech)

  • Heiko Runz

    (Biogen)

  • Mark J. Daly

    (University of Helsinki
    Broad Institute of Harvard and MIT
    Broad Institute of Harvard and MIT
    Massachusetts General Hospital)

  • Aarno Palotie

    (University of Helsinki
    Broad Institute of Harvard and MIT
    Broad Institute of Harvard and MIT
    Massachusetts General Hospital)

Abstract

Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency

Suggested Citation

  • Mitja I. Kurki & Juha Karjalainen & Priit Palta & Timo P. Sipilä & Kati Kristiansson & Kati M. Donner & Mary P. Reeve & Hannele Laivuori & Mervi Aavikko & Mari A. Kaunisto & Anu Loukola & Elisa Lahtel, 2023. "FinnGen provides genetic insights from a well-phenotyped isolated population," Nature, Nature, vol. 613(7944), pages 508-518, January.
    • Handle: RePEc:nat:nature:v:613:y:2023:i:7944:d:10.1038_s41586-022-05473-8
    DOI: 10.1038/s41586-022-05473-8
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