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Maternal polycystic ovary syndrome and Offspring’s Risk of Cardiovascular diseases in Childhood and Young Adulthood

Author

Listed:
  • Fen Yang

    (Karolinska Institutet
    Karolinska Institutet)

  • Ziliang Wang

    (Shanghai Institute for Biomedical and Pharmaceutical Technologies
    Aarhus University Hospital)

  • Henrik Toft Sørensen

    (Aarhus University and Aarhus University Hospital)

  • Imre Janszky

    (Karolinska Institutet
    Norwegian University of Science and Technology)

  • Mika Gissler

    (Finnish Institute for Health and Welfare
    Region Stockholm
    Karolinska Institutet)

  • Wei Yuan

    (Shanghai Institute for Biomedical and Pharmaceutical Technologies)

  • Maohua Miao

    (Shanghai Institute for Biomedical and Pharmaceutical Technologies)

  • Nathalie Roos

    (Karolinska University Hospital and Karolinska Institutet)

  • Anna-Karin Wikström

    (Uppsala University)

  • Jiong Li

    (Aarhus University Hospital)

  • Krisztina D. László

    (Karolinska Institutet
    Uppsala University)

Abstract

Children born to mothers with polycystic ovary syndrome have a higher prevalence of cardiovascular risk factors and of subclinical cardiovascular disease, but the association between maternal polycystic ovary syndrome and cardiovascular disease in offspring is unclear. We conduct a register-based cohort study of 6 839 703 live singleton births from Denmark (1973–2016) and Sweden (1973–2014) and follow them for up to 48 years. Using Cox regression models, we find that offspring of mothers with polycystic ovary syndrome have a higher risk of overall cardiovascular diseases and of its specific subtypes, independently of comorbidities related to polycystic ovary syndrome. Cousin analyzes suggest that familial confounding does not explain our results. If our findings are replicated by future studies, children of women with polycystic ovary syndrome may benefit from early cardiovascular prevention efforts.

Suggested Citation

  • Fen Yang & Ziliang Wang & Henrik Toft Sørensen & Imre Janszky & Mika Gissler & Wei Yuan & Maohua Miao & Nathalie Roos & Anna-Karin Wikström & Jiong Li & Krisztina D. László, 2024. "Maternal polycystic ovary syndrome and Offspring’s Risk of Cardiovascular diseases in Childhood and Young Adulthood," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54795-w
    DOI: 10.1038/s41467-024-54795-w
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    References listed on IDEAS

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    1. D'Onofrio, B.M. & Lahey, B.B. & Turkheimer, E. & Lichtenstein, P., 2013. "Critical need for family-based, quasi-experimental designs in integrating genetic and social science research," American Journal of Public Health, American Public Health Association, vol. 103(SUPPL.1), pages 46-55.
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