IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-54559-6.html
   My bibliography  Save this article

Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases

Author

Listed:
  • Teofila Seremet

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Jeremy Di Domizio

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Antoine Girardin

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Ahmad Yatim

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Raphael Jenelten

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Francesco Messina

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Fanny Saidoune

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Christoph Schlapbach

    (University of Bern)

  • Sofia Bogiatzi

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Frederic Minisini

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Natalie Garzorz-Stark

    (University of Freiburg)

  • Matthieu Leuenberger

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Héloise Wüthrich

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Maxime Vernez

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Daniel Hohl

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Stefanie Eyerich

    (University of Freiburg)

  • Kilian Eyerich

    (University of Freiburg)

  • Emmanuella Guenova

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Carle Paul

    (CHU Toulouse)

  • Raphael Gottardo

    (and SIB)

  • Curdin Conrad

    (Lausanne University Hospital CHUV and University of Lausanne)

  • Michel Gilliet

    (Lausanne University Hospital CHUV and University of Lausanne)

Abstract

Previous advances have identified immune pathways associated with inflammatory skin diseases, leading to the development of targeted therapies. However, there is a lack of molecular approaches that delineate these pathways at the individual patient level for personalized diagnostic and therapeutic guidance. Here, we conduct a cross-comparison of expression profiles from multiple inflammatory skin diseases to identify gene modules defining relevant immune pathways. Seven modules are identified, representing key immune pathways: Th17, Th2, Th1, Type I IFNs, neutrophilic, macrophagic, and eosinophilic. These modules allow the development of a molecular map with high diagnostic efficacy for inflammatory skin diseases and clinico-pathologically undetermined cases. Aligning dominant modules with treatment targets offers a rational framework for treatment selection, improving response rates in both treatment-naïve patients and non-responders to targeted therapies. Overall, our approach offers precision medicine for inflammatory skin diseases, utilizing transcriptional modules to support diagnosis and guide personalized treatment selection.

Suggested Citation

  • Teofila Seremet & Jeremy Di Domizio & Antoine Girardin & Ahmad Yatim & Raphael Jenelten & Francesco Messina & Fanny Saidoune & Christoph Schlapbach & Sofia Bogiatzi & Frederic Minisini & Natalie Garzo, 2024. "Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54559-6
    DOI: 10.1038/s41467-024-54559-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-54559-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-54559-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. A. Schäbitz & C. Hillig & M. Mubarak & M. Jargosch & A. Farnoud & E. Scala & N. Kurzen & A. C. Pilz & N. Bhalla & J. Thomas & M. Stahle & T. Biedermann & C. B. Schmidt-Weber & F. Theis & N. Garzorz-St, 2022. "Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseases," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Curdin Conrad & Jeremy Di Domizio & Alessio Mylonas & Cyrine Belkhodja & Olivier Demaria & Alexander A. Navarini & Anne-Karine Lapointe & Lars E. French & Maxime Vernez & Michel Gilliet, 2018. "TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Christine Bangert & Natalia Alkon & Sumanth Chennareddy & Tamara Arnoldner & Jasmine P. Levine & Magdalena Pilz & Marco A. Medjimorec & John Ruggiero & Emry R. Cohenour & Constanze Jonak & William Dam, 2024. "Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Xiangyu Lu & Le Kuai & Fang Huang & Jingsi Jiang & Jiankun Song & Yiqiong Liu & Si Chen & Lijie Mao & Wei Peng & Ying Luo & Yongyong Li & Haiqing Dong & Bin Li & Jianlin Shi, 2023. "Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Anissa Fries & Fanny Saidoune & François Kuonen & Isabelle Dupanloup & Nadine Fournier & Ana Cristina Guerra de Souza & Muzlifah Haniffa & Feiyang Ma & Johann E. Gudjonsson & Lennart Roesner & Yang Li, 2023. "Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54559-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.