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Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis

Author

Listed:
  • Anissa Fries

    (CHUV University Hospital and University of Lausanne (UNIL))

  • Fanny Saidoune

    (CHUV University Hospital and University of Lausanne (UNIL))

  • François Kuonen

    (CHUV University Hospital and University of Lausanne (UNIL))

  • Isabelle Dupanloup

    (Agora Cancer Research Center, Swiss Institute of Bioinformatics)

  • Nadine Fournier

    (Agora Cancer Research Center, Swiss Institute of Bioinformatics)

  • Ana Cristina Guerra de Souza

    (Agora Cancer Research Center, Swiss Institute of Bioinformatics)

  • Muzlifah Haniffa

    (Newcastle Hospitals NHS Foundation Trust)

  • Feiyang Ma

    (University of Michigan)

  • Johann E. Gudjonsson

    (University of Michigan)

  • Lennart Roesner

    (Hannover Medical School
    Hannover Medical School)

  • Yang Li

    (Hannover Medical School (MHH))

  • Thomas Werfel

    (Hannover Medical School
    Hannover Medical School)

  • Curdin Conrad

    (CHUV University Hospital and University of Lausanne (UNIL))

  • Raphael Gottardo

    (Biomedical Data Sciences Center, CHUV, UNIL, and SIB)

  • Robert L. Modlin

    (University of California)

  • Jeremy Di Domizio

    (CHUV University Hospital and University of Lausanne (UNIL))

  • Michel Gilliet

    (CHUV University Hospital and University of Lausanne (UNIL))

Abstract

Interleukin (IL)-26 is a TH17 cytokine with known antimicrobial and pro-inflammatory functions. However, the precise role of IL-26 in the context of pathogenic TH17 responses is unknown. Here we identify a population of blood TH17 intermediates that produce high levels of IL-26 and differentiate into IL-17A-producing TH17 cells upon TGF-β1 exposure. By combining single cell RNA sequencing, TCR sequencing and spatial transcriptomics we show that this process occurs in psoriatic skin. In fact, IL-26+ TH17 intermediates infiltrating psoriatic skin induce TGF-β1 expression in basal keratinocytes and thereby promote their own differentiation into IL-17A-producing cells. Thus, our study identifies IL-26-producing cells as an early differentiation stage of TH17 cells that infiltrates psoriatic skin and controls its own maturation into IL17A-producing TH17 cells, via epithelial crosstalk involving paracrine production of TGF-β1.

Suggested Citation

  • Anissa Fries & Fanny Saidoune & François Kuonen & Isabelle Dupanloup & Nadine Fournier & Ana Cristina Guerra de Souza & Muzlifah Haniffa & Feiyang Ma & Johann E. Gudjonsson & Lennart Roesner & Yang Li, 2023. "Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39484-4
    DOI: 10.1038/s41467-023-39484-4
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    2. Nanna Fyhrquist & Gareth Muirhead & Stefanie Prast-Nielsen & Marine Jeanmougin & Peter Olah & Tiina Skoog & Gerome Jules-Clement & Micha Feld & Mauricio Barrientos-Somarribas & Hanna Sinkko & Ellen H., 2019. "Microbe-host interplay in atopic dermatitis and psoriasis," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
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