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The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3

Author

Listed:
  • Zhuo Han

    (State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University)

  • Rui Wang

    (Key Laboratory of Organ Regeneration and Reconstruction, UCAS/IOZ/CAS
    Beijing Institute of Stem Cell and Regenerative Medicine
    the First People’s Hospital of Yunnan Province)

  • Pengliang Chi

    (State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University)

  • Zihan Zhang

    (State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University)

  • Ling Min

    (State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University)

  • Haizhan Jiao

    (School of Medicine, The Chinese University of Hong Kong (Shenzhen))

  • Guojin Ou

    (State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University
    West China Second University Hospital, Sichuan University)

  • Dan Zhou

    (Key Laboratory of Organ Regeneration and Reconstruction, UCAS/IOZ/CAS
    Beijing Institute of Stem Cell and Regenerative Medicine)

  • Dandan Qin

    (Key Laboratory of Organ Regeneration and Reconstruction, UCAS/IOZ/CAS
    Beijing Institute of Stem Cell and Regenerative Medicine)

  • Chengpeng Xu

    (Key Laboratory of Organ Regeneration and Reconstruction, UCAS/IOZ/CAS
    Beijing Institute of Stem Cell and Regenerative Medicine)

  • Zheng Gao

    (Center for Reproductive Medicine, The Third Affiliated Hospital of Guangzhou Medical University)

  • Qianqian Qi

    (West China Second University Hospital, Sichuan University)

  • Jialu Li

    (State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University)

  • Yuechao Lu

    (State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University
    West China Second University Hospital, Sichuan University)

  • Xiang Wang

    (State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University
    Sichuan University
    Sichuan University)

  • Jing Chen

    (Department of Pediatric Surgery, West China Hospital, Sichuan University)

  • Xingjiang Yu

    (Key Laboratory of Organ Regeneration and Reconstruction, UCAS/IOZ/CAS
    Beijing Institute of Stem Cell and Regenerative Medicine)

  • Hongli Hu

    (School of Medicine, The Chinese University of Hong Kong (Shenzhen))

  • Lei Li

    (Key Laboratory of Organ Regeneration and Reconstruction, UCAS/IOZ/CAS
    Beijing Institute of Stem Cell and Regenerative Medicine)

  • Dong Deng

    (State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University
    Sichuan University
    Sichuan University)

Abstract

The subcortical maternal complex (SCMC) is essential for safeguarding female fertility in mammals. Assembled in oocytes, the SCMC maintains the cleavage of early embryos, but the underlying mechanism remains unclear. Here, we report that 14-3-3, a multifunctional protein, is a component of the SCMC. By resolving the structure of the 14-3-3-containing SCMC, we discover that phosphorylation of TLE6 contributes to the recruitment of 14-3-3. Mechanistically, during maternal-to-embryo transition, the SCMC stabilizes 14-3-3 protein and contributes to the proper control of CDC25B, thus ensuring the activation of the maturation-promoting factor and mitotic entry in mouse zygotes. Notably, the SCMC establishes a conserved molecular link with 14-3-3 and CDC25B in human oocytes/embryos. This study discloses the molecular mechanism through which the SCMC regulates the cell cycle in early embryos and elucidates the function of the SCMC in mammalian early embryogenesis.

Suggested Citation

  • Zhuo Han & Rui Wang & Pengliang Chi & Zihan Zhang & Ling Min & Haizhan Jiao & Guojin Ou & Dan Zhou & Dandan Qin & Chengpeng Xu & Zheng Gao & Qianqian Qi & Jialu Li & Yuechao Lu & Xiang Wang & Jing Che, 2024. "The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53277-3
    DOI: 10.1038/s41467-024-53277-3
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    References listed on IDEAS

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