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Maternal effect of Hsf1 on reproductive success

Author

Listed:
  • E. Christians

    (University of Liège)

  • A. A. Davis

    (University of Texas Southwestern Medical Center
    Alcon Laboratories)

  • S. D. Thomas

    (University of Texas Southwestern Medical Center)

  • I. J. Benjamin

    (University of Texas Southwestern Medical Center
    Division of Cell and Molecular Biology University of Texas Southwestern Medical Center)

Abstract

A protein known as heat-shock factor-1 (HSF1) is a major transactivator of stress-inducible genes in response to environmental changes, but it is also implicated in extra-embryonic development and female fertility in mice1,2. Here we show that mouse embryos whose mothers lack this protein are unable to develop properly beyond the zygotic stage, although oocytes were ovulated and fertilized normally. Wild-type spermatozoa do not save zygotes from lethality, indicating that the reproductive failure of females deficient in this factor is caused by a 'maternal effect' mutation3, and that HSF1 from the mother normally controls early post-fertilization development.

Suggested Citation

  • E. Christians & A. A. Davis & S. D. Thomas & I. J. Benjamin, 2000. "Maternal effect of Hsf1 on reproductive success," Nature, Nature, vol. 407(6805), pages 693-694, October.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6805:d:10.1038_35037669
    DOI: 10.1038/35037669
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    Cited by:

    1. Lei Chen & Chen Chu & Xiangyin Kong & Guohua Huang & Tao Huang & Yu-Dong Cai, 2015. "A Hybrid Computational Method for the Discovery of Novel Reproduction-Related Genes," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-15, March.
    2. Zhuo Han & Rui Wang & Pengliang Chi & Zihan Zhang & Ling Min & Haizhan Jiao & Guojin Ou & Dan Zhou & Dandan Qin & Chengpeng Xu & Zheng Gao & Qianqian Qi & Jialu Li & Yuechao Lu & Xiang Wang & Jing Che, 2024. "The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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