IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-52522-z.html
   My bibliography  Save this article

Quantifiable blood TCR repertoire components associate with immune aging

Author

Listed:
  • Jing Hu

    (University of Pennsylvania
    Children’s Hospital of Philadelphia)

  • Mingyao Pan

    (University of Pennsylvania)

  • Brett Reid

    (Moffitt Cancer Center)

  • Shelley Tworoger

    (Moffitt Cancer Center
    Oregon Health and Science University)

  • Bo Li

    (University of Pennsylvania
    Children’s Hospital of Philadelphia)

Abstract

T cell senescence alters the homeostasis of distinct T cell populations and results in decayed adaptive immune protection in older individuals, but a link between aging and dynamic T cell clone changes has not been made. Here, using a newly developed computational framework, Repertoire Functional Units (RFU), we investigate over 6500 publicly available TCR repertoire sequencing samples from multiple human cohorts and identify age-associated RFUs consistently across different cohorts. Quantification of RFU reduction with aging reveals accelerated loss under immunosuppressive conditions. Systematic analysis of age-associated RFUs in clinical samples manifests a potential link between these RFUs and improved clinical outcomes, such as lower ICU admission and reduced risk of complications, during acute viral infections. Finally, patients receiving bone marrow transplantation show a secondary expansion of the age-associated clones upon stem cell transfer from younger donors. Together, our results suggest the existence of a ‘TCR clock’ that could reflect the immune functions in aging populations.

Suggested Citation

  • Jing Hu & Mingyao Pan & Brett Reid & Shelley Tworoger & Bo Li, 2024. "Quantifiable blood TCR repertoire components associate with immune aging," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52522-z
    DOI: 10.1038/s41467-024-52522-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-52522-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-52522-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Bonnie van Wilgenburg & Iris Scherwitzl & Edward C. Hutchinson & Tianqi Leng & Ayako Kurioka & Corinna Kulicke & Catherine de Lara & Suzanne Cole & Sirijitt Vasanawathana & Wannee Limpitikul & Prida M, 2016. "MAIT cells are activated during human viral infections," Nature Communications, Nature, vol. 7(1), pages 1-11, September.
    2. Cecily Choy & Joseph Chen & Jiangyuan Li & D. Travis Gallagher & Jian Lu & Daichao Wu & Ainslee Zou & Humza Hemani & Beverly A. Baptiste & Emily Wichmann & Qian Yang & Jeffrey Ciffelo & Rui Yin & Juli, 2023. "SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Pradyot Dash & Andrew J. Fiore-Gartland & Tomer Hertz & George C. Wang & Shalini Sharma & Aisha Souquette & Jeremy Chase Crawford & E. Bridie Clemens & Thi H. O. Nguyen & Katherine Kedzierska & Nicole, 2017. "Quantifiable predictive features define epitope-specific T cell receptor repertoires," Nature, Nature, vol. 547(7661), pages 89-93, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ivy K Brown & Nathan Dyjack & Mindy M Miller & Harsha Krovi & Cydney Rios & Rachel Woolaver & Laura Harmacek & Ting-Hui Tu & Brian P O’Connor & Thomas Danhorn & Brian Vestal & Laurent Gapin & Clemenci, 2021. "Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4+ T cell repertoire," PLOS Pathogens, Public Library of Science, vol. 17(6), pages 1-34, June.
    2. Felix Drost & Yang An & Irene Bonafonte-Pardàs & Lisa M. Dratva & Rik G. H. Lindeboom & Muzlifah Haniffa & Sarah A. Teichmann & Fabian Theis & Mohammad Lotfollahi & Benjamin Schubert, 2024. "Multi-modal generative modeling for joint analysis of single-cell T cell receptor and gene expression data," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Estelle Marrer-Berger & Annalisa Nicastri & Angelique Augustin & Vesna Kramar & Hanqing Liao & Lydia Jasmin Hanisch & Alejandro Carpy & Tina Weinzierl & Evelyne Durr & Nathalie Schaub & Ramona Nudisch, 2024. "The physiological interactome of TCR-like antibody therapeutics in human tissues," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Lauren Stern & Helen M. McGuire & Selmir Avdic & Barbara Fazekas de St Groth & David Gottlieb & Allison Abendroth & Emily Blyth & Barry Slobedman, 2022. "Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Ann-Christin Gnirck & Marie-Sophie Philipp & Alex Waterhölter & Malte Wunderlich & Nikhat Shaikh & Virginia Adamiak & Lena Henneken & Tobias Kautz & Tingting Xiong & Daniela Klaus & Pascal Tomczyk & M, 2023. "Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52522-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.