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Quantifiable predictive features define epitope-specific T cell receptor repertoires

Author

Listed:
  • Pradyot Dash

    (St Jude Children’s Research Hospital)

  • Andrew J. Fiore-Gartland

    (Fred Hutchinson Cancer Research Center)

  • Tomer Hertz

    (Fred Hutchinson Cancer Research Center
    Immunology and Genetics, Ben-Gurion University of the Negev)

  • George C. Wang

    (Biology of Healthy Aging Program, Johns Hopkins University School of Medicine)

  • Shalini Sharma

    (Lala Lajpat Rai University of Veterinary and Animal Sciences)

  • Aisha Souquette

    (St Jude Children’s Research Hospital)

  • Jeremy Chase Crawford

    (St Jude Children’s Research Hospital)

  • E. Bridie Clemens

    (University of Melbourne, Peter Doherty Institute for Infection and Immunity)

  • Thi H. O. Nguyen

    (University of Melbourne, Peter Doherty Institute for Infection and Immunity)

  • Katherine Kedzierska

    (University of Melbourne, Peter Doherty Institute for Infection and Immunity)

  • Nicole L. La Gruta

    (University of Melbourne, Peter Doherty Institute for Infection and Immunity
    Biomedicine Discovery Institute, Monash University)

  • Philip Bradley

    (Fred Hutchinson Cancer Research Center
    Institute for Protein Design, University of Washington)

  • Paul G. Thomas

    (St Jude Children’s Research Hospital)

Abstract

The authors characterize epitope-specific T cell repertoires, identify shared and recognizable features of TCRs, and develop tools to classify antigen specificity on the basis of sequence analysis.

Suggested Citation

  • Pradyot Dash & Andrew J. Fiore-Gartland & Tomer Hertz & George C. Wang & Shalini Sharma & Aisha Souquette & Jeremy Chase Crawford & E. Bridie Clemens & Thi H. O. Nguyen & Katherine Kedzierska & Nicole, 2017. "Quantifiable predictive features define epitope-specific T cell receptor repertoires," Nature, Nature, vol. 547(7661), pages 89-93, July.
    • Handle: RePEc:nat:nature:v:547:y:2017:i:7661:d:10.1038_nature22383
    DOI: 10.1038/nature22383
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    Citations

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    Cited by:

    1. Estelle Marrer-Berger & Annalisa Nicastri & Angelique Augustin & Vesna Kramar & Hanqing Liao & Lydia Jasmin Hanisch & Alejandro Carpy & Tina Weinzierl & Evelyne Durr & Nathalie Schaub & Ramona Nudisch, 2024. "The physiological interactome of TCR-like antibody therapeutics in human tissues," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Jing Hu & Mingyao Pan & Brett Reid & Shelley Tworoger & Bo Li, 2024. "Quantifiable blood TCR repertoire components associate with immune aging," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Ivy K Brown & Nathan Dyjack & Mindy M Miller & Harsha Krovi & Cydney Rios & Rachel Woolaver & Laura Harmacek & Ting-Hui Tu & Brian P O’Connor & Thomas Danhorn & Brian Vestal & Laurent Gapin & Clemenci, 2021. "Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4+ T cell repertoire," PLOS Pathogens, Public Library of Science, vol. 17(6), pages 1-34, June.
    4. Felix Drost & Yang An & Irene Bonafonte-Pardàs & Lisa M. Dratva & Rik G. H. Lindeboom & Muzlifah Haniffa & Sarah A. Teichmann & Fabian Theis & Mohammad Lotfollahi & Benjamin Schubert, 2024. "Multi-modal generative modeling for joint analysis of single-cell T cell receptor and gene expression data," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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