IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-52404-4.html
   My bibliography  Save this article

Post-COVID-19 condition symptoms among emergency department patients tested for SARS-CoV-2 infection

Author

Listed:
  • Patrick M. Archambault

    (Université Laval
    Centre intégré de santé et de services sociaux de Chaudière-Appalaches
    VITAM — Centre de recherche en santé durable)

  • Rhonda J. Rosychuk

    (University of Alberta)

  • Martyne Audet

    (Centre intégré de santé et de services sociaux de Chaudière-Appalaches)

  • Jeffrey P. Hau

    (The University of British Columbia)

  • Lorraine Graves

    (The University of British Columbia)

  • Simon Décary

    (Université de Sherbrooke)

  • Jeffrey J. Perry

    (University of Ottawa
    Ottawa Hospital Research Institute)

  • Steven C. Brooks

    (Queen’s University
    Queen’s University)

  • Laurie J. Morrison

    (University of Toronto)

  • Raoul Daoust

    (Université de Montréal
    Hôpital du Sacré-Cœur-de-Montréal)

  • David Seonguk Yeom

    (The University of British Columbia)

  • Hana Wiemer

    (Dalhousie University)

  • Patrick T. Fok

    (Dalhousie University)

  • Andrew D. McRae

    (University of Calgary
    University of Calgary)

  • Kavish Chandra

    (Dalhousie Medicine New Brunswick)

  • Michelle E. Kho

    (McMaster University
    The Research Institute of St. Joe’s Hamilton)

  • Dawn Stacey

    (Ottawa Hospital Research Institute
    University of Ottawa)

  • Bilkis Vissandjée

    (Université de Montréal)

  • Matthew Menear

    (Université Laval
    VITAM — Centre de recherche en santé durable)

  • Eric Mercier

    (Université Laval
    VITAM — Centre de recherche en santé durable
    Centre de recherche du CHU de Québec—Université Laval
    Hôpital de l’Enfant-Jésus)

  • Samuel Vaillancourt

    (University of Toronto
    Unity Health Toronto)

  • Samina Aziz

    (Public Health Agency of Canada)

  • Dianne Zakaria

    (Public Health Agency of Canada)

  • Phil Davis

    (University of Saskatchewan)

  • Katie N. Dainty

    (North York General Hospital
    University of Toronto)

  • Jean-Sébastien Paquette

    (Université Laval
    VITAM — Centre de recherche en santé durable)

  • Murdoch Leeies

    (University of Manitoba)

  • Susie Goulding

    (The University of British Columbia
    COVID Long-Haulers Support Group Canada)

  • Elyse Berger Pelletier

    (Université Laval)

  • Corinne M. Hohl

    (The University of British Columbia)

Abstract

Symptoms of the Post-COVID-19 Condition are often non-specific making it a challenge to distinguish them from symptoms due to other medical conditions. In this study, we compare the proportion of emergency department patients who developed symptoms consistent with the World Health Organization’s Post-COVID-19 Condition clinical case definition between those who tested positive for Severe Acute Respiratory Syndrome Coronavirus-2 infection and time-matched patients who tested negative. Our results show that over one-third of emergency department patients with a proven acute infection meet Post-COVID-19 Condition criteria 3 months post-index visit. However, one in five test-negative patients who claim never having been infected also report symptoms consistent with Post-COVID-19 Condition highlighting the lack of specificity of the clinical case definition. Testing for SARS-CoV-2 during the acute phase of a suspected infection should continue until specific biomarkers of Post-COVID-19 Condition become available for diagnosis and treatment.

Suggested Citation

  • Patrick M. Archambault & Rhonda J. Rosychuk & Martyne Audet & Jeffrey P. Hau & Lorraine Graves & Simon Décary & Jeffrey J. Perry & Steven C. Brooks & Laurie J. Morrison & Raoul Daoust & David Seonguk , 2024. "Post-COVID-19 condition symptoms among emergency department patients tested for SARS-CoV-2 infection," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52404-4
    DOI: 10.1038/s41467-024-52404-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-52404-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-52404-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Michael A. Horberg & Eric Watson & Mamta Bhatia & Celeena Jefferson & Julia M. Certa & Seohyun Kim & Lily Fathi & Keri N. Althoff & Carolyn Williams & Richard Moore, 2022. "Post-acute sequelae of SARS-CoV-2 with clinical condition definitions and comparison in a matched cohort," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Mohd Radzniwan Abdul Rashid & Sharifah Najwa Syed Mohamad & Ahmad Izzat Ahmad Tajjudin & Nuruliza Roslan & Aida Jaffar & Fathima Begum Syed Mohideen & Faizul Helmi Addnan & Nizam Baharom & Muslimah It, 2023. "COVID-19 Pandemic Fatigue and Its Sociodemographic, Mental Health Status, and Perceived Causes: A Cross-Sectional Study Nearing the Transition to an Endemic Phase in Malaysia," IJERPH, MDPI, vol. 20(5), pages 1-18, March.
    3. Ellen J. Thompson & Dylan M. Williams & Alex J. Walker & Ruth E. Mitchell & Claire L. Niedzwiedz & Tiffany C. Yang & Charlotte F. Huggins & Alex S. F. Kwong & Richard J. Silverwood & Giorgio Di Gessa , 2022. "Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ziqi Liu & Ziqiao Yin & Zhilong Mi & Binghui Guo, 2023. "Long-COVID Inducement Mechanism Based on the Path Module Correlation Coefficient," Mathematics, MDPI, vol. 11(6), pages 1-14, March.
    2. Nicole H. Goldhaber & Jordan N. Kohn & William Scott Ogan & Amy Sitapati & Christopher A. Longhurst & Angela Wang & Susan Lee & Suzi Hong & Lucy E. Horton, 2022. "Deep Dive into the Long Haul: Analysis of Symptom Clusters and Risk Factors for Post-Acute Sequelae of COVID-19 to Inform Clinical Care," IJERPH, MDPI, vol. 19(24), pages 1-13, December.
    3. Kirsten McEwan & Harriet Collett & Jean Nairn & Jamie Bird & Mark A. Faghy & Eric Pfeifer & Jessica E. Jackson & Caroline Cook & Amanda Bond, 2022. "The Feasibility and Impact of Practising Online Forest Bathing to Improve Anxiety, Rumination, Social Connection and Long-COVID Symptoms: A Pilot Study," IJERPH, MDPI, vol. 19(22), pages 1-12, November.
    4. Claire E. Hastie & David J. Lowe & Andrew McAuley & Nicholas L. Mills & Andrew J. Winter & Corri Black & Janet T. Scott & Catherine A. O’Donnell & David N. Blane & Susan Browne & Tracy R. Ibbotson & J, 2023. "Natural history of long-COVID in a nationwide, population cohort study," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    5. Jia Wei & Philippa C. Matthews & Nicole Stoesser & John N. Newton & Ian Diamond & Ruth Studley & Nick Taylor & John I. Bell & Jeremy Farrar & Jaison Kolenchery & Brian D. Marsden & Sarah Hoosdally & E, 2023. "Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Lucrezia Ginevra Lulli & Antonio Baldassarre & Annarita Chiarelli & Antonella Mariniello & Diana Paolini & Maddalena Grazzini & Nicola Mucci & Giulio Arcangeli, 2023. "Physical Impact of SARS-CoV-2 Infection in a Population of Italian Healthcare Workers," IJERPH, MDPI, vol. 20(5), pages 1-14, March.
    7. B-A. Reme & J. Gjesvik & K. Magnusson, 2023. "Predictors of the post-COVID condition following mild SARS-CoV-2 infection," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    8. Christina J. Atchison & Bethan Davies & Emily Cooper & Adam Lound & Matthew Whitaker & Adam Hampshire & Adriana Azor & Christl A. Donnelly & Marc Chadeau-Hyam & Graham S. Cooke & Helen Ward & Paul Ell, 2023. "Long-term health impacts of COVID-19 among 242,712 adults in England," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52404-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.