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Mycobacterium tuberculosis cough aerosol culture status associates with host characteristics and inflammatory profiles

Author

Listed:
  • Videlis Nduba

    (Kenya Medical Research Institute)

  • Lilian N. Njagi

    (Kenya Medical Research Institute)

  • Wilfred Murithi

    (Kenya Medical Research Institute)

  • Zipporah Mwongera

    (Kenya Medical Research Institute)

  • Jodi Byers

    (University of Washington)

  • Gisella Logioia

    (University of Washington)

  • Glenna Peterson

    (University of Washington)

  • R. Max Segnitz

    (University of Washington)

  • Kevin Fennelly

    (National Institutes of Health)

  • Thomas R. Hawn

    (University of Washington)

  • David J. Horne

    (University of Washington
    University of Washington)

Abstract

Interrupting transmission events is critical to tuberculosis control. Cough-generated aerosol cultures predict tuberculosis transmission better than microbiological or clinical markers. We hypothesize that highly infectious individuals with pulmonary tuberculosis (positive for cough aerosol cultures) have elevated inflammatory markers and unique transcriptional profiles compared to less infectious individuals. We performed a prospective, longitudinal study using cough aerosol sampling system. We enrolled 142 participants with treatment-naïve pulmonary tuberculosis in Kenya and assessed the association of clinical, microbiologic, and immunologic characteristics with Mycobacterium tuberculosis aerosolization and transmission in 129 household members. Contacts of the forty-three aerosol culture-positive participants (30%) are more likely to have a positive interferon-gamma release assay (85% vs 53%, P = 0.006) and higher median IFNγ level (P

Suggested Citation

  • Videlis Nduba & Lilian N. Njagi & Wilfred Murithi & Zipporah Mwongera & Jodi Byers & Gisella Logioia & Glenna Peterson & R. Max Segnitz & Kevin Fennelly & Thomas R. Hawn & David J. Horne, 2024. "Mycobacterium tuberculosis cough aerosol culture status associates with host characteristics and inflammatory profiles," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52122-x
    DOI: 10.1038/s41467-024-52122-x
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    References listed on IDEAS

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