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Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases

Author

Listed:
  • Akuzike Kalizang’oma

    (University College London
    Malawi Liverpool Wellcome Programme
    Kamuzu University of Health Sciences)

  • Damien Richard

    (University College London)

  • Brenda Kwambana-Adams

    (University College London
    Malawi Liverpool Wellcome Programme
    Kamuzu University of Health Sciences
    Liverpool School of Tropical Medicine)

  • Juliana Coelho

    (Colindale)

  • Karen Broughton

    (Colindale)

  • Bruno Pichon

    (Colindale)

  • Katie L. Hopkins

    (Colindale)

  • Victoria Chalker

    (NHS Blood and Transplant)

  • Sandra Beleza

    (Department of Genetics and Genome Biology)

  • Stephen D. Bentley

    (Wellcome Sanger Institute)

  • Chrispin Chaguza

    (University College London
    Wellcome Sanger Institute
    Yale University
    Yale University)

  • Robert S. Heyderman

    (University College London)

Abstract

Streptococcus mitis is a leading cause of infective endocarditis (IE). However, our understanding of the genomic epidemiology and pathogenicity of IE-associated S. mitis is hampered by low IE incidence. Here we use whole genome sequencing of 129 S. mitis bloodstream infection (BSI) isolates collected between 2001–2016 from clinically diagnosed IE cases in the UK to investigate genetic diversity, antimicrobial resistance, and pathogenicity. We show high genetic diversity of IE-associated S. mitis with virtually all isolates belonging to distinct lineages indicating no predominance of specific lineages. Additionally, we find a highly variable distribution of known pneumococcal virulence genes among the isolates, some of which are overrepresented in disease when compared to carriage strains. Our findings suggest that S. mitis in patients with clinically diagnosed IE is not primarily caused by specific hypervirulent or antimicrobial resistant lineages, highlighting the accidental pathogenic nature of S. mitis in patients with clinically diagnosed IE.

Suggested Citation

  • Akuzike Kalizang’oma & Damien Richard & Brenda Kwambana-Adams & Juliana Coelho & Karen Broughton & Bruno Pichon & Katie L. Hopkins & Victoria Chalker & Sandra Beleza & Stephen D. Bentley & Chrispin Ch, 2024. "Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52120-z
    DOI: 10.1038/s41467-024-52120-z
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    References listed on IDEAS

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