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An economic demand-based framework for prioritization strategies in response to transient amino acid limitations

Author

Listed:
  • Ritu Gupta

    (Institute for Stem Cell Science and Regenerative Medicine (inStem)
    NIH)

  • Swagata Adhikary

    (Institute for Stem Cell Science and Regenerative Medicine (inStem)
    Manipal Academy of Higher Education)

  • Nidhi Dalpatraj

    (Institute for Stem Cell Science and Regenerative Medicine (inStem))

  • Sunil Laxman

    (Institute for Stem Cell Science and Regenerative Medicine (inStem))

Abstract

Cells contain disparate amounts of distinct amino acids, each of which has different metabolic and chemical origins, but the supply cost vs demand requirements of each is unclear. Here, using yeast we quantify the restoration-responses after disrupting amino acid supply, and uncover a hierarchically prioritized restoration strategy for distinct amino acids. We comprehensively calculate individual amino acid biosynthetic supply costs, quantify total demand for an amino acid, and estimate cumulative supply/demand requirements for each amino acid. Through this, we discover that the restoration priority is driven by the gross demand for an amino acid, which is itself coupled to low supply costs for that amino acid. Demand from metabolic requirements dominate the demand-pulls for an amino acid, as exemplified by the largest restoration response upon disrupting arginine supply. Collectively, this demand-driven framework that drives the amino acid economy can identify novel amino acid responses, and help design metabolic engineering applications.

Suggested Citation

  • Ritu Gupta & Swagata Adhikary & Nidhi Dalpatraj & Sunil Laxman, 2024. "An economic demand-based framework for prioritization strategies in response to transient amino acid limitations," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51769-w
    DOI: 10.1038/s41467-024-51769-w
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    References listed on IDEAS

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    1. Ronnie J. Phillips & Daniel J. Slottje, 1983. "The Importance of Relative Prices in Analyzing Veblen Effects," Journal of Economic Issues, Taylor & Francis Journals, vol. 17(1), pages 197-206, March.
    2. Viridiana Olin-Sandoval & Jason Shu Lim Yu & Leonor Miller-Fleming & Mohammad Tauqeer Alam & Stephan Kamrad & Clara Correia-Melo & Robert Haas & Joanna Segal & David Alejandro Peña Navarro & Lucia Her, 2019. "Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism," Nature, Nature, vol. 572(7768), pages 249-253, August.
    3. Rosemary Yu & Kate Campbell & Rui Pereira & Johan Björkeroth & Qi Qi & Egor Vorontsov & Carina Sihlbom & Jens Nielsen, 2020. "Nitrogen limitation reveals large reserves in metabolic and translational capacities of yeast," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
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