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A real-world observation of patients with glioblastoma treated with a personalized peptide vaccine

Author

Listed:
  • Pauline Latzer

    (Zentrum für Humangenetik Tübingen)

  • Henning Zelba

    (Zentrum für Humangenetik Tübingen)

  • Florian Battke

    (CeGaT GmbH)

  • Annekathrin Reinhardt

    (Zentrum für Humangenetik Tübingen)

  • Borong Shao

    (Zentrum für Humangenetik Tübingen)

  • Oliver Bartsch

    (Zentrum für Humangenetik Tübingen)

  • Armin Rabsteyn

    (Zentrum für Humangenetik Tübingen)

  • Johannes Harter

    (CeGaT GmbH)

  • Martin Schulze

    (Zentrum für Humangenetik Tübingen)

  • Thomas Okech

    (MVZ Zentrum für ambulante Onkologie GmbH)

  • Alexander Golf

    (MVZ Zentrum für ambulante Onkologie GmbH)

  • Christina Kyzirakos-Feger

    (Zentrum für Humangenetik Tübingen)

  • Simone Kayser

    (Zentrum für Humangenetik Tübingen)

  • Natalia Pieper

    (Zentrum für Humangenetik Tübingen)

  • Magdalena Feldhahn

    (CeGaT GmbH)

  • Julian Wünsche

    (Zentrum für Humangenetik Tübingen
    MVZ Zentrum für ambulante Onkologie GmbH)

  • Christian Seitz

    (KiTZ, Hopp Children’s Cancer Center)

  • Dirk Hadaschik

    (CeCaVa GmbH)

  • Claus Garbe

    (University Hospital Tübingen)

  • Till-Karsten Hauser

    (Universitätsklinikum Tübingen)

  • Christian Fougère

    (Universitätsklinikum Tübingen)

  • Dirk Biskup

    (CeGaT GmbH)

  • Dawn Brooke

    (Provenance Precision Medicine Foundation)

  • David Parker

    (PHM)

  • Uwe M. Martens

    (Cancer Center Heilbronn-Franken, SLK Kliniken GmbH)

  • Gerald Illerhaus

    (Klinikum Stuttgart)

  • Deborah T. Blumenthal

    (Tel-Aviv University)

  • Ryan Merrell

    (Vanderbilt University Medical Center)

  • Luisa Sánchez Lorenzo

    (Clínica Universidad de Navarra)

  • Máté Hidvégi

    (Jewish Theological Seminary—University of Jewish Studies (OR-ZSE))

  • Paula Robles

    (University of Calgary
    Tom Baker Cancer Centre)

  • Sied Kebir

    (Universitätsklinikum Essen)

  • William W. Li

    (Angiogenesis Foundation)

  • Vincent W. Li

    (Angiogenesis Foundation
    Harvard Medical School Dermatology)

  • Matthew Williams

    (NHS London)

  • Alexandra M. Miller

    (NYU Langone Health’s Perlmutter Cancer Center)

  • Santosh Kesari

    (Providence Saint John’s Health Center)

  • Michael Castro

    (Cellworks Group Inc
    Personalized Cancer Medicine, PLLC)

  • Annick Desjardins

    (Duke University Medical Center)

  • David M. Ashley

    (Duke University Medical Center
    Duke University)

  • Henry S. Friedman

    (Duke University Medical Center)

  • Patrick Y. Wen

    (Harvard Medical School)

  • Elisabeth C. Neil

    (University of Minnesota Health)

  • Fabio M. Iwamoto

    (Columbia University Medical Center)

  • Bence Sipos

    (Molekularpathologie Baden-Württemberg GbR)

  • Karsten Geletneky

    (Klinikum Darmstadt GmbH)

  • Lars Zender

    (Internal Medicine VIII)

  • Martin Glas

    (Universitätsklinikum Essen Klinik für Neurologie)

  • David A. Reardon

    (Harvard Medical School)

  • Saskia Biskup

    (Zentrum für Humangenetik Tübingen
    CeGaT GmbH)

Abstract

Current treatment outcome of patients with glioblastoma (GBM) remains poor. Following standard therapy, recurrence is universal with limited survival. Tumors from 173 GBM patients are analysed for somatic mutations to generate a personalized peptide vaccine targeting tumor-specific neoantigens. All patients were treated within the scope of an individual healing attempt. Among all vaccinated patients, including 70 treated prior to progression (primary) and 103 treated after progression (recurrent), the median overall survival from first diagnosis is 31.9 months (95% CI: 25.0–36.5). Adverse events are infrequent and are predominantly grade 1 or 2. A vaccine-induced immune response to at least one of the vaccinated peptides is detected in blood samples of 87 of 97 (90%) monitored patients. Vaccine-specific T-cell responses are durable in most patients. Significantly prolonged survival is observed for patients with multiple vaccine-induced T-cell responses (53 months) compared to those with no/low induced responses (27 months; P = 0.03). Altogether, our results highlight that the application of personalized neoantigen-targeting peptide vaccine is feasible and represents a promising potential treatment option for GBM patients.

Suggested Citation

  • Pauline Latzer & Henning Zelba & Florian Battke & Annekathrin Reinhardt & Borong Shao & Oliver Bartsch & Armin Rabsteyn & Johannes Harter & Martin Schulze & Thomas Okech & Alexander Golf & Christina K, 2024. "A real-world observation of patients with glioblastoma treated with a personalized peptide vaccine," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51315-8
    DOI: 10.1038/s41467-024-51315-8
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    References listed on IDEAS

    as
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