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Genome-wide variation study and inter-tissue communication analysis unveil regulatory mechanisms of egg-laying performance in chickens

Author

Listed:
  • Dandan Wang

    (Henan Agricultural University
    Henan Institute of Science and Technology)

  • Lizhi Tan

    (China Agricultural University)

  • Yihao Zhi

    (Henan Agricultural University)

  • Lina Bu

    (China Agricultural University)

  • Yangyang Wang

    (Henan Agricultural University)

  • Zhang Wang

    (Henan Agricultural University)

  • Yulong Guo

    (Henan Agricultural University)

  • Weihua Tian

    (Henan Agricultural University)

  • Chunlin Xu

    (Henan Sangao Agriculture and Animal Husbandry Co, Ltd)

  • Donghua Li

    (Henan Agricultural University
    International Joint Research Laboratory for Poultry Breeding of Henan)

  • Zhuanjian Li

    (Henan Agricultural University
    International Joint Research Laboratory for Poultry Breeding of Henan)

  • Ruirui Jiang

    (Henan Agricultural University
    International Joint Research Laboratory for Poultry Breeding of Henan)

  • Ruili Han

    (Henan Agricultural University
    International Joint Research Laboratory for Poultry Breeding of Henan)

  • Guoxi Li

    (Henan Agricultural University
    International Joint Research Laboratory for Poultry Breeding of Henan)

  • Yongqiang Wang

    (Henan Institute of Science and Technology)

  • Dong Xia

    (The Royal Veterinary College)

  • Yadong Tian

    (Henan Agricultural University
    International Joint Research Laboratory for Poultry Breeding of Henan)

  • Ian C. Dunn

    (University of Edinburgh)

  • Xiaoxiang Hu

    (China Agricultural University)

  • Hong Li

    (Henan Agricultural University
    International Joint Research Laboratory for Poultry Breeding of Henan)

  • Yiqiang Zhao

    (China Agricultural University)

  • Xiangtao Kang

    (Henan Agricultural University
    International Joint Research Laboratory for Poultry Breeding of Henan)

  • Xiaojun Liu

    (Henan Agricultural University
    International Joint Research Laboratory for Poultry Breeding of Henan)

Abstract

Egg-laying performance is of great economic importance in poultry, but the underlying genetic mechanisms are still elusive. In this work, we conduct a multi-omics and multi-tissue integrative study in hens with distinct egg production, to detect the hub candidate genes and construct hub molecular networks contributing to egg-laying phenotypic differences. We identifiy three hub candidate genes as egg-laying facilitators: TFPI2, which promotes the GnRH secretion in hypothalamic neuron cells; CAMK2D, which promotes the FSHβ and LHβ secretion in pituitary cells; and OSTN, which promotes granulosa cell proliferation and the synthesis of sex steroid hormones. We reveal key endocrine factors involving egg production by inter-tissue crosstalk analysis, and demonstrate that both a hepatokine, APOA4, and an adipokine, ANGPTL2, could increase egg production by inter-tissue communication with hypothalamic-pituitary-ovarian axis. Together, These results reveal the molecular mechanisms of multi-tissue coordinative regulation of chicken egg-laying performance and provide key insights to avian reproductive regulation.

Suggested Citation

  • Dandan Wang & Lizhi Tan & Yihao Zhi & Lina Bu & Yangyang Wang & Zhang Wang & Yulong Guo & Weihua Tian & Chunlin Xu & Donghua Li & Zhuanjian Li & Ruirui Jiang & Ruili Han & Guoxi Li & Yongqiang Wang & , 2024. "Genome-wide variation study and inter-tissue communication analysis unveil regulatory mechanisms of egg-laying performance in chickens," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50809-9
    DOI: 10.1038/s41467-024-50809-9
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    1. Carl-Johan Rubin & Michael C. Zody & Jonas Eriksson & Jennifer R. S. Meadows & Ellen Sherwood & Matthew T. Webster & Lin Jiang & Max Ingman & Ted Sharpe & Sojeong Ka & Finn Hallböök & Francois Besnier, 2010. "Whole-genome resequencing reveals loci under selection during chicken domestication," Nature, Nature, vol. 464(7288), pages 587-591, March.
    2. Diyan Li & Chunyou Ning & Jiaman Zhang & Yujie Wang & Qianzi Tang & Hua Kui & Tao Wang & Mengnan He & Long Jin & Jing Li & Yu Lin & Bo Zeng & Huadong Yin & Xiaoling Zhao & Yao Zhang & Huailiang Xu & Q, 2022. "Dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Zhengkui Zhou & Ming Li & Hong Cheng & Wenlei Fan & Zhengrong Yuan & Qiang Gao & Yaxi Xu & Zhanbao Guo & Yunsheng Zhang & Jian Hu & Hehe Liu & Dapeng Liu & Weihuang Chen & Zhuqing Zheng & Yong Jiang &, 2018. "Author Correction: An intercross population study reveals genes associated with body size and plumage color in ducks," Nature Communications, Nature, vol. 9(1), pages 1-1, December.
    4. Zhengkui Zhou & Ming Li & Hong Cheng & Wenlei Fan & Zhengrong Yuan & Qiang Gao & Yaxi Xu & Zhanbao Guo & Yunsheng Zhang & Jian Hu & Hehe Liu & Dapeng Liu & Weihuang Chen & Zhuqing Zheng & Yong Jiang &, 2018. "An intercross population study reveals genes associated with body size and plumage color in ducks," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
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