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Dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis

Author

Listed:
  • Diyan Li

    (Sichuan Agricultural University)

  • Chunyou Ning

    (Sichuan Agricultural University)

  • Jiaman Zhang

    (Sichuan Agricultural University)

  • Yujie Wang

    (Sichuan Agricultural University)

  • Qianzi Tang

    (Sichuan Agricultural University)

  • Hua Kui

    (Sichuan Agricultural University)

  • Tao Wang

    (Sichuan Agricultural University)

  • Mengnan He

    (Sichuan Agricultural University)

  • Long Jin

    (Sichuan Agricultural University)

  • Jing Li

    (Sichuan Agricultural University)

  • Yu Lin

    (Sichuan Agricultural University)

  • Bo Zeng

    (Sichuan Agricultural University)

  • Huadong Yin

    (Sichuan Agricultural University)

  • Xiaoling Zhao

    (Sichuan Agricultural University)

  • Yao Zhang

    (Sichuan Agricultural University)

  • Huailiang Xu

    (Sichuan Agricultural University)

  • Qing Zhu

    (Sichuan Agricultural University)

  • Mingzhou Li

    (Sichuan Agricultural University)

Abstract

Folliculogenesis is a complex biological process involving a central oocyte and its surrounding somatic cells. Three-dimensional chromatin architecture is an important transcription regulator; however, little is known about its dynamics and role in transcriptional regulation of granulosa cells during chicken folliculogenesis. We investigate the transcriptomic dynamics of chicken granulosa cells over ten follicular stages and assess the chromatin architecture dynamics and how it influences gene expression in granulosa cells at three key stages: the prehierarchical small white follicles, the first largest preovulatory follicles, and the postovulatory follicles. Our results demonstrate the consistency between the global reprogramming of chromatin architecture and the transcriptomic divergence during folliculogenesis, providing ample evidence for compartmentalization rearrangement, variable organization of topologically associating domains, and rewiring of the long-range interaction between promoter and enhancers. These results provide key insights into avian reproductive biology and provide a foundational dataset for the future in-depth functional characterization of granulosa cells.

Suggested Citation

  • Diyan Li & Chunyou Ning & Jiaman Zhang & Yujie Wang & Qianzi Tang & Hua Kui & Tao Wang & Mengnan He & Long Jin & Jing Li & Yu Lin & Bo Zeng & Huadong Yin & Xiaoling Zhao & Yao Zhang & Huailiang Xu & Q, 2022. "Dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27800-9
    DOI: 10.1038/s41467-021-27800-9
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    Cited by:

    1. Dandan Wang & Lizhi Tan & Yihao Zhi & Lina Bu & Yangyang Wang & Zhang Wang & Yulong Guo & Weihua Tian & Chunlin Xu & Donghua Li & Zhuanjian Li & Ruirui Jiang & Ruili Han & Guoxi Li & Yongqiang Wang & , 2024. "Genome-wide variation study and inter-tissue communication analysis unveil regulatory mechanisms of egg-laying performance in chickens," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Linyong Shen & Xue Bai & Liru Zhao & Jiamei Zhou & Cheng Chang & Xinquan Li & Zhiping Cao & Yumao Li & Peng Luan & Hui Li & Hui Zhang, 2024. "Integrative 3D genomics with multi-omics analysis and functional validation of genetic regulatory mechanisms of abdominal fat deposition in chickens," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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