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An intercross population study reveals genes associated with body size and plumage color in ducks

Author

Listed:
  • Zhengkui Zhou

    (Chinese Academy of Agricultural Sciences)

  • Ming Li

    (Northwest A&F University)

  • Hong Cheng

    (Northwest A&F University)

  • Wenlei Fan

    (Chinese Academy of Agricultural Sciences)

  • Zhengrong Yuan

    (Beijing Forestry University)

  • Qiang Gao

    (Chinese Academy of Sciences)

  • Yaxi Xu

    (Chinese Academy of Agricultural Sciences
    Northwest A&F University)

  • Zhanbao Guo

    (Chinese Academy of Agricultural Sciences)

  • Yunsheng Zhang

    (Chinese Academy of Agricultural Sciences)

  • Jian Hu

    (Chinese Academy of Agricultural Sciences)

  • Hehe Liu

    (Chinese Academy of Agricultural Sciences)

  • Dapeng Liu

    (Chinese Academy of Agricultural Sciences)

  • Weihuang Chen

    (Northwest A&F University)

  • Zhuqing Zheng

    (Northwest A&F University)

  • Yong Jiang

    (Chinese Academy of Agricultural Sciences)

  • Zhiguo Wen

    (Chinese Academy of Agricultural Sciences)

  • Yongming Liu

    (Chinese Academy of Sciences)

  • Hua Chen

    (Chinese Academy of Sciences)

  • Ming Xie

    (Chinese Academy of Agricultural Sciences)

  • Qi Zhang

    (Chinese Academy of Agricultural Sciences)

  • Wei Huang

    (Chinese Academy of Agricultural Sciences)

  • Wen Wang

    (Northwestern Polytechnical University)

  • Shuisheng Hou

    (Chinese Academy of Agricultural Sciences)

  • Yu Jiang

    (Northwest A&F University)

Abstract

Comparative population genomics offers an opportunity to discover the signatures of artificial selection during animal domestication, however, their function cannot be directly revealed. We discover the selection signatures using genome-wide comparisons among 40 mallards, 36 indigenous-breed ducks, and 30 Pekin ducks. Then, the phenotypes are fine-mapped based on resequencing of 1026 ducks from an F2 segregating population generated by wild × domestic crosses. Interestingly, the two key economic traits of Pekin duck are associated with two selective sweeps with fixed mutations. A novel intronic insertion most possibly leads to a splicing change in MITF accounted for white duck down feathers. And a putative long-distance regulatory mutation causes continuous expression of the IGF2BP1 gene after birth which increases body size by 15% and feed efficiency by 6%. This study provides new insights into genotype–phenotype associations in animal research and constitutes a promising resource on economically important genes in fowl.

Suggested Citation

  • Zhengkui Zhou & Ming Li & Hong Cheng & Wenlei Fan & Zhengrong Yuan & Qiang Gao & Yaxi Xu & Zhanbao Guo & Yunsheng Zhang & Jian Hu & Hehe Liu & Dapeng Liu & Weihuang Chen & Zhuqing Zheng & Yong Jiang &, 2018. "An intercross population study reveals genes associated with body size and plumage color in ducks," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04868-4
    DOI: 10.1038/s41467-018-04868-4
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    Cited by:

    1. Feng Zhu & Zhong-Tao Yin & Zheng Wang & Jacqueline Smith & Fan Zhang & Fergal Martin & Denye Ogeh & Maxwell Hincke & Fang-Bing Lin & David W. Burt & Zheng-Kui Zhou & Shui-Sheng Hou & Qiang-Sen Zhao & , 2021. "Three chromosome-level duck genome assemblies provide insights into genomic variation during domestication," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Lihong Gu & Feng Wang & Zhemin Lin & Tieshan Xu & Dajie Lin & Manping Xing & Shaoxiong Yang & Zhe Chao & Baoguo Ye & Peng Lin & Chunhui Hui & Lizhi Lu & Shuisheng Hou, 2020. "Genetic characteristics of Jiaji Duck by whole genome re-sequencing," PLOS ONE, Public Library of Science, vol. 15(2), pages 1-15, February.

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