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A single-particle mechanofluorescent sensor

Author

Listed:
  • Narges Ahmadi

    (Kyung Hee University)

  • Jieun Lee

    (Kyung Hee University)

  • Chirag Batukbhai Godiya

    (Kyung Hee University)

  • Jong-Man Kim

    (Hanyang University)

  • Bum Jun Park

    (Kyung Hee University)

Abstract

Monitoring mechanical stresses in microchannels is challenging. Herein, we report the development of a mechanofluorescence sensor system featuring a fluorogenic single polydiacetylene (PDA) particle, fabricated using a co-flow microfluidic method. We construct a stenotic vessel-mimicking capillary channel, in which the hydrodynamically captured PDA particle is subjected to controlled fluid flows. Fluorescence responses of the PDA particle are directly monitored in real time using fluorescent microscopy. The PDA particle displays significant nonlinear fluorescence emissions influenced by fluid viscosity and the presence of nanoparticles and biomolecules in the fluid. This nonlinear response is likely attributed to the torsion energy along the PDA’s main chain backbone. Computational fluid dynamic simulations indicate that the complete blue-to-red transition necessitates ~307 μJ, aligning with prior research. We believe this study offers a unique advantage for simulating specific problematic regions of the human body in an in vitro environment, potentially paving the way for future exploration of difficult-to-access areas within the body.

Suggested Citation

  • Narges Ahmadi & Jieun Lee & Chirag Batukbhai Godiya & Jong-Man Kim & Bum Jun Park, 2024. "A single-particle mechanofluorescent sensor," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50361-6
    DOI: 10.1038/s41467-024-50361-6
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    References listed on IDEAS

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    1. Joosub Lee & Minkyeong Pyo & Sang-hwa Lee & Jaeyong Kim & Moonsoo Ra & Whoi-Yul Kim & Bum Jun Park & Chan Woo Lee & Jong-Man Kim, 2014. "Hydrochromic conjugated polymers for human sweat pore mapping," Nature Communications, Nature, vol. 5(1), pages 1-10, September.
    2. Ajay K. Singh & Dong-Hyeon Ko & Niraj K. Vishwakarma & Seungwook Jang & Kyoung-Ik Min & Dong-Pyo Kim, 2016. "Micro-total envelope system with silicon nanowire separator for safe carcinogenic chemistry," Nature Communications, Nature, vol. 7(1), pages 1-7, April.
    3. Abhishek Jain & Amanda Graveline & Anna Waterhouse & Andyna Vernet & Robert Flaumenhaft & Donald E. Ingber, 2016. "A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function," Nature Communications, Nature, vol. 7(1), pages 1-10, April.
    4. Hongxia Fu & Yan Jiang & Darren Yang & Friedrich Scheiflinger & Wesley P. Wong & Timothy A. Springer, 2017. "Flow-induced elongation of von Willebrand factor precedes tension-dependent activation," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    5. Jung Lee & Hyun Taek Chang & Hyosung An & Sora Ahn & Jina Shim & Jong-Man Kim, 2013. "A protective layer approach to solvatochromic sensors," Nature Communications, Nature, vol. 4(1), pages 1-9, December.
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