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Micro-total envelope system with silicon nanowire separator for safe carcinogenic chemistry

Author

Listed:
  • Ajay K. Singh

    (National Center of Applied Microfluidic Chemistry, POSTECH (Pohang University of Science and Technology))

  • Dong-Hyeon Ko

    (National Center of Applied Microfluidic Chemistry, POSTECH (Pohang University of Science and Technology))

  • Niraj K. Vishwakarma

    (National Center of Applied Microfluidic Chemistry, POSTECH (Pohang University of Science and Technology))

  • Seungwook Jang

    (National Center of Applied Microfluidic Chemistry, POSTECH (Pohang University of Science and Technology))

  • Kyoung-Ik Min

    (National Center of Applied Microfluidic Chemistry, POSTECH (Pohang University of Science and Technology))

  • Dong-Pyo Kim

    (National Center of Applied Microfluidic Chemistry, POSTECH (Pohang University of Science and Technology))

Abstract

Exploration and expansion of the chemistries involving toxic or carcinogenic reagents are severely limited by the health hazards their presence poses. Here, we present a micro-total envelope system (μ-TES) and an automated total process for the generation of the carcinogenic reagent, its purification and its utilization for a desired synthesis that is totally enveloped from being exposed to the carcinogen. A unique microseparator is developed on the basis of SiNWs structure to replace the usual exposure-prone distillation in separating the generated reagent. Chloromethyl methyl ether chemistry is explored as a carcinogenic model in demonstrating the efficiency of the μ-TES that is fully automated so that feeding the ingredients for the generation is all it takes to produce the desired product. Syntheses taking days can be accomplished safely in minutes with excellent yields, which bodes well for elevating the carcinogenic chemistry to new unexplored dimensions.

Suggested Citation

  • Ajay K. Singh & Dong-Hyeon Ko & Niraj K. Vishwakarma & Seungwook Jang & Kyoung-Ik Min & Dong-Pyo Kim, 2016. "Micro-total envelope system with silicon nanowire separator for safe carcinogenic chemistry," Nature Communications, Nature, vol. 7(1), pages 1-7, April.
  • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10741
    DOI: 10.1038/ncomms10741
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    Cited by:

    1. Narges Ahmadi & Jieun Lee & Chirag Batukbhai Godiya & Jong-Man Kim & Bum Jun Park, 2024. "A single-particle mechanofluorescent sensor," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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