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Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians

Author

Listed:
  • Joeri Meijsen

    (Mental Health Services Copenhagen University Hospital)

  • Kejia Hu

    (Karolinska Institutet)

  • Morten D. Krebs

    (Mental Health Services Copenhagen University Hospital)

  • Georgios Athanasiadis

    (Mental Health Services Copenhagen University Hospital
    University of Barcelona)

  • Sarah Washbrook

    (Mental Health Services in the Capital Region of Denmark)

  • Richard Zetterberg

    (Mental Health Services Copenhagen University Hospital)

  • Raquel Nogueira Avelar e Silva

    (Mental Health Services Copenhagen University Hospital)

  • John R. Shorter

    (Mental Health Services Copenhagen University Hospital
    Roskilde University)

  • Jesper R. Gådin

    (Mental Health Services Copenhagen University Hospital)

  • Jacob Bergstedt

    (Karolinska Institutet)

  • David M. Howard

    (King’s College London)

  • Weimin Ye

    (Karolinska Institutet)

  • Yi Lu

    (Karolinska Institutet)

  • Unnur A. Valdimarsdóttir

    (Karolinska Institutet
    University of Iceland
    Harvard T.H. Chan School of Public Health)

  • Andrés Ingason

    (Mental Health Services Copenhagen University Hospital)

  • Dorte Helenius

    (Mental Health Services Copenhagen University Hospital)

  • Oleguer Plana-Ripoll

    (Aarhus University and Aarhus University Hospital)

  • John J. McGrath

    (Queensland Centre for Mental Health Research
    The University of Queensland
    Aarhus University)

  • Nadia Micali

    (Mental Health Services Copenhagen University Hospital
    Mental Health Services in the Capital Region of Denmark
    University College London)

  • Ole A. Andreassen

    (Oslo University Hospital
    University of Oslo
    University of Oslo)

  • Thomas M. Werge

    (Mental Health Services Copenhagen University Hospital
    University of Copenhagen)

  • Fang Fang

    (Karolinska Institutet)

  • Alfonso Buil

    (Mental Health Services Copenhagen University Hospital)

Abstract

Mental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders. Genetic factors contributed about 50% to the comorbidity of schizophrenia, affective disorders, and autism spectrum disorder with cardiometabolic disorders, whereas the comorbidity of attention-deficit/hyperactivity disorder and anorexia with cardiometabolic disorders was mainly or fully driven by environmental factors. In this work we provide causal insight to guide clinical and scientific initiatives directed at achieving mechanistic understanding as well as preventing and alleviating the consequences of these disorders.

Suggested Citation

  • Joeri Meijsen & Kejia Hu & Morten D. Krebs & Georgios Athanasiadis & Sarah Washbrook & Richard Zetterberg & Raquel Nogueira Avelar e Silva & John R. Shorter & Jesper R. Gådin & Jacob Bergstedt & David, 2024. "Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49507-3
    DOI: 10.1038/s41467-024-49507-3
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