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Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Author

Listed:
  • Vassily Trubetskoy

    (Charité - Universitätsmedizin)

  • Antonio F. Pardiñas

    (Cardiff University)

  • Ting Qi

    (University of Queensland
    Westlake University)

  • Georgia Panagiotaropoulou

    (Charité - Universitätsmedizin)

  • Swapnil Awasthi

    (Charité - Universitätsmedizin)

  • Tim B. Bigdeli

    (SUNY Downstate Medical Center
    SUNY Downstate Medical Center
    Veterans Affairs New York Harbor Healthcare System)

  • Julien Bryois

    (Karolinska Institutet)

  • Chia-Yen Chen

    (Biogen
    Massachusetts General Hospital
    Massachusetts General Hospital)

  • Charlotte A. Dennison

    (Cardiff University)

  • Lynsey S. Hall

    (Cardiff University)

  • Max Lam

    (Broad Institute of MIT and Harvard
    Research Division, Institute of Mental Health
    Zucker Hillside Hospital)

  • Kyoko Watanabe

    (Vrije Universiteit Amsterdam)

  • Oleksandr Frei

    (University of Oslo
    Oslo University Hospital
    University of Oslo)

  • Tian Ge

    (Massachusetts General Hospital
    Broad Institute of MIT and Harvard
    Harvard Medical School)

  • Janet C. Harwood

    (Cardiff University)

  • Frank Koopmans

    (Vrije Universiteit)

  • Sigurdur Magnusson

    (deCODE Genetics, Amgen)

  • Alexander L. Richards

    (Cardiff University)

  • Julia Sidorenko

    (University of Queensland)

  • Yang Wu

    (University of Queensland)

  • Jian Zeng

    (University of Queensland)

  • Jakob Grove

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
    Aarhus University
    Center for Genomics and Personalized Medicine)

  • Minsoo Kim

    (University of California Los Angeles)

  • Zhiqiang Li

    (Qingdao University
    Shanghai Jiao Tong University)

  • Georgios Voloudakis

    (Icahn School of Medicine at Mount Sinai)

  • Wen Zhang

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Mark Adams

    (University of Edinburgh, Royal Edinburgh Hospital)

  • Ingrid Agartz

    (University of Oslo
    Diakonhjemmet Hospital
    Karolinska Institutet and Stockholm Health Care Services, Stockholm Region)

  • Elizabeth G. Atkinson

    (Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Esben Agerbo

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
    Aarhus University)

  • Mariam Al Eissa

    (University College London)

  • Margot Albus

    (Comedicum Lindwurmhof)

  • Madeline Alexander

    (Center for Depression, Anxiety and Stress Research, McLean Hospital)

  • Behrooz Z. Alizadeh

    (University of Groningen
    University of Groningen)

  • Köksal Alptekin

    (Dokuz Eylül University School of Medicine
    Dokuz Eylül University Graduate School of Health Sciences)

  • Thomas D. Als

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
    Aarhus University
    Center for Genomics and Personalized Medicine)

  • Farooq Amin

    (Emory University)

  • Volker Arolt

    (University of Münster)

  • Manuel Arrojo

    (Servizo Galego de Saúde (SERGAS))

  • Lavinia Athanasiu

    (University of Oslo
    Oslo University Hospital)

  • Maria Helena Azevedo

    (University of Coimbra)

  • Silviu A. Bacanu

    (Virginia Commonwealth University)

  • Nicholas J. Bass

    (University College London)

  • Martin Begemann

    (Max Planck Institute of Experimental Medicine)

  • Richard A. Belliveau

    (Broad Institute of MIT and Harvard)

  • Judit Bene

    (University of Pécs)

  • Beben Benyamin

    (University of South Australia
    University of South Australia
    South Australian Health and Medical Research Institute)

  • Sarah E. Bergen

    (Karolinska Institutet)

  • Giuseppe Blasi

    (University of Bari ‘Aldo Moro’)

  • Julio Bobes

    (Hospital Universitario Central de Asturias (HUCA)
    Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
    Centro de Investigación Biomédica en Red de Salud Mental)

  • Stefano Bonassi

    (Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma and San Raffaele University)

  • Alice Braun

    (Charité - Universitätsmedizin)

  • Rodrigo Affonseca Bressan

    (Universidade Federal de São Paulo
    Universidade Federal de São Paulo)

  • Evelyn J. Bromet

    (Stony Brook University)

  • Richard Bruggeman

    (University of Groningen
    University of Groningen)

  • Peter F. Buckley

    (University of Tennessee)

  • Randy L. Buckner

    (Harvard University)

  • Jonas Bybjerg-Grauholm

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
    Statens Serum Institut)

  • Wiepke Cahn

    (Rudolf Magnus Institute of Neuroscience
    Altrecht, General Menthal Health Care)

  • Murray J. Cairns

    (University of Newcastle
    Hunter Medical Research Institute
    University of Newcastle)

  • Monica E. Calkins

    (University of Pennsylvania)

  • Vaughan J. Carr

    (University of New South Wales
    Monash University
    Neuroscience Research Australia)

  • David Castle

    (University of Melbourne
    St Vincent’s Hospital)

  • Stanley V. Catts

    (The University of Sydney
    University of Queensland)

  • Kimberley D. Chambert

    (Broad Institute of MIT and Harvard)

  • Raymond C. K. Chan

    (Chinese Academy of Science
    University of Chinese Academy of Sciences)

  • Boris Chaumette

    (INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Université de Paris, GHU Paris Psychiatrie & Neurosciences
    McGill University)

  • Wei Cheng

    (University of North Carolina)

  • Eric F. C. Cheung

    (Castle Peak Hospital)

  • Siow Ann Chong

    (Research Division, Institute of Mental Health
    National University of Singapore)

  • David Cohen

    (Hôpital Universitaire de la Pitié-Salpêtrière
    Hôpital Universitaire de la Pitié-Salpêtrière
    Sorbonne Université)

  • Angèle Consoli

    (Hôpital Universitaire de la Pitié-Salpêtrière
    Hôpital Universitaire de la Pitié-Salpêtrière)

  • Quirino Cordeiro

    (Irmandade da Santa Casa de Misericórdia de São Paulo)

  • Javier Costas

    (Servizo Galego de Saúde (SERGAS))

  • Charles Curtis

    (King’s College London
    National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London)

  • Michael Davidson

    (University of Nicosia Medical School)

  • Kenneth L. Davis

    (Icahn School of Medicine at Mount Sinai)

  • Lieuwe Haan

    (University of Amsterdam
    Arkin, Institute for Mental Health)

  • Franziska Degenhardt

    (University of Bonn)

  • Lynn E. DeLisi

    (Harvard Medical School
    Cambridge Health Alliance)

  • Ditte Demontis

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
    Aarhus University
    Center for Genomics and Personalized Medicine)

  • Faith Dickerson

    (Sheppard Pratt Health System)

  • Dimitris Dikeos

    (National and Kapodistrian University of Athens, Eginition Hospital)

  • Timothy Dinan

    (University College Cork
    University College Cork)

  • Srdjan Djurovic

    (University of Bergen
    Oslo University Hospital)

  • Jubao Duan

    (NorthShore University HealthSystem
    The University of Chicago)

  • Giuseppe Ducci

    (Department of Mental Health, ASL Rome 1)

  • Frank Dudbridge

    (University of Leicester)

  • Johan G. Eriksson

    (University of Helsinki and Helsinki University Hospital
    Folkhälsan Research Center
    National University of Singapore)

  • Lourdes Fañanás

    (University of Barcelona
    Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM))

  • Stephen V. Faraone

    (SUNY Upstate Medical University)

  • Alessia Fiorentino

    (University College London)

  • Andreas Forstner

    (University of Bonn
    University of Marburg)

  • Josef Frank

    (University of Heidelberg)

  • Nelson B. Freimer

    (University of California Los Angeles
    University of California Los Angeles)

  • Menachem Fromer

    (Icahn School of Medicine at Mount Sinai)

  • Alessandra Frustaci

    (Barnet, Enfield and Haringey Mental Health NHS Trust, St Ann’s Hospital)

  • Ary Gadelha

    (Universidade Federal de São Paulo
    Universidade Federal de São Paulo)

  • Giulio Genovese

    (Broad Institute of MIT and Harvard)

  • Elliot S. Gershon

    (University of Chicago)

  • Marianna Giannitelli

    (Hôpital Universitaire de la Pitié-Salpêtrière
    Hôpital Universitaire de la Pitié-Salpêtrière)

  • Ina Giegling

    (Medical University of Vienna)

  • Paola Giusti-Rodríguez

    (University of North Carolina)

  • Stephanie Godard

    (Institut de Myologie, Hôpital de la Pitiè-Salpêtrière)

  • Jacqueline I. Goldstein

    (Massachusetts General Hospital)

  • Javier González Peñas

    (Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)
    General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense)

  • Ana González-Pinto

    (Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)
    University of the Basque Country)

  • Srihari Gopal

    (Janssen Research and Development)

  • Jacob Gratten

    (University of Queensland
    University of Queensland)

  • Michael F. Green

    (Geffen School of Medicine, University of California Los Angeles
    VA Greater Los Angeles Healthcare System)

  • Tiffany A. Greenwood

    (University of California San Diego)

  • Olivier Guillin

    (INSERM
    Centre Hospitalier du Rouvray
    Université de Rouen Normandie)

  • Sinan Gülöksüz

    (School for Mental Health and Neuroscience, Maastricht University Medical Centre
    Yale School of Medicine)

  • Raquel E. Gur

    (University of Pennsylvania)

  • Ruben C. Gur

    (University of Pennsylvania)

  • Blanca Gutiérrez

    (University of Granada)

  • Eric Hahn

    (Charité - Universitätsmedizin)

  • Hakon Hakonarson

    (Children’s Hospital of Philadelphia, Leonard Madlyn Abramson Research Center)

  • Vahram Haroutunian

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Mental Illness Research Clinical and Education Center (MIRECC), JJ Peters VA Medical Center)

  • Annette M. Hartmann

    (Medical University of Vienna)

  • Carol Harvey

    (University of Melbourne
    NorthWestern Mental Health)

  • Caroline Hayward

    (University of Edinburgh, Institute of Genetics and Cancer, Western General Hospital)

  • Frans A. Henskens

    (University of Newcastle)

  • Stefan Herms

    (University of Basel)

  • Per Hoffmann

    (University of Basel)

  • Daniel P. Howrigan

    (Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Masashi Ikeda

    (Fujita Health University School of Medicine)

  • Conrad Iyegbe

    (King’s College London)

  • Inge Joa

    (Stavanger University Hospital)

  • Antonio Julià

    (Rheumatology Research Group, Vall d’Hebron Research Institute)

  • Anna K. Kähler

    (Karolinska Institutet)

  • Tony Kam-Thong

    (Roche Innovation Center Basel, F. Hoffman-La Roche)

  • Yoichiro Kamatani

    (The University of Tokyo
    Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences)

  • Sena Karachanak-Yankova

    (Medical University
    Sofia University “St. Kliment Ohridski”)

  • Oussama Kebir

    (INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Université de Paris, GHU Paris Psychiatrie & Neurosciences)

  • Matthew C. Keller

    (University of Colorado Boulder)

  • Brian J. Kelly

    (University of Newcastle)

  • Andrey Khrunin

    (Institute of Molecular Genetics of National Research Centre “Kurchatov Institute”)

  • Sung-Wan Kim

    (Chonnam National University Medical School)

  • Janis Klovins

    (Latvian Biomedical Research and Study Centre)

  • Nikolay Kondratiev

    (Mental Health Research Center)

  • Bettina Konte

    (Medical University of Vienna)

  • Julia Kraft

    (Charité - Universitätsmedizin
    Berlin School of Mind and Brain, Humboldt-Universität zu Berlin)

  • Michiaki Kubo

    (RIKEN Center for Integrative Medical Sciences)

  • Vaidutis Kučinskas

    (Vilnius University)

  • Zita Ausrele Kučinskiene

    (Vilnius University)

  • Agung Kusumawardhani

    (University of Indonesia - Cipto Mangunkusumo National General Hospital)

  • Hana Kuzelova-Ptackova

    (1st Faculty of Medicine and General University Hospital)

  • Stefano Landi

    (Universita’ di Pisa)

  • Laura C. Lazzeroni

    (Stanford University
    Stanford University)

  • Phil H. Lee

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital, Harvard Medical School)

  • Sophie E. Legge

    (Cardiff University)

  • Douglas S. Lehrer

    (Wright State University)

  • Rebecca Lencer

    (University of Münster)

  • Bernard Lerer

    (Hadassah-Hebrew University Medical Center)

  • Miaoxin Li

    (Sun Yat-sen University)

  • Jeffrey Lieberman

    (Columbia University)

  • Gregory A. Light

    (University of California San Diego
    VISN 22, Mental Illness Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System)

  • Svetlana Limborska

    (Institute of Molecular Genetics of National Research Centre “Kurchatov Institute”)

  • Chih-Min Liu

    (National Taiwan University Hospital
    National Taiwan University)

  • Jouko Lönnqvist

    (National Institute for Health and Welfare
    University of Helsinki)

  • Carmel M. Loughland

    (Hunter New England Health and University of Newcastle)

  • Jan Lubinski

    (Pomeranian Medical University in Szczecin)

  • Jurjen J. Luykx

    (School for Mental Health and Neuroscience, Maastricht University Medical Centre
    Utrecht University
    Utrecht University
    Second Opinion Outpatient Clinic, GGNet Mental Health)

  • Amy Lynham

    (Cardiff University)

  • Milan Macek

    (2nd Faculty of Medicine and University Hospital Motol)

  • Andrew Mackinnon

    (University of New South Wales
    University of Melbourne)

  • Patrik K. E. Magnusson

    (Karolinska Institutet)

  • Brion S. Maher

    (Johns Hopkins University)

  • Wolfgang Maier

    (University Hospital Bonn)

  • Dolores Malaspina

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Jacques Mallet

    (Hôpital Universitaire de la Pitié-Salpêtrière)

  • Stephen R. Marder

    (University of California Los Angeles)

  • Sara Marsal

    (Rheumatology Research Group, Vall d’Hebron Research Institute)

  • Alicia R. Martin

    (Massachusetts General Hospital
    Broad Institute of MIT and Harvard
    Harvard Medical School)

  • Lourdes Martorell

    (Hospital Universitari Institut Pere Mata, IISPV, Universitat Rovira i Virgili, CIBERSAM)

  • Manuel Mattheisen

    (Aarhus University
    Dalhousie University
    Dalhousie University
    University Hospital, LMU Munich)

  • Robert W. McCarley

    (VA Boston Health Care System)

  • Colm McDonald

    (National University of Ireland Galway)

  • John J. McGrath

    (Aarhus University
    University of Queensland
    The Park Centre for Mental Health)

  • Helena Medeiros

    (University of Southern California
    SUNY Downstate Health Sciences University)

  • Sandra Meier

    (Dalhousie University
    Aarhus University)

  • Bela Melegh

    (University of Pécs, School of Medicine)

  • Ingrid Melle

    (University of Oslo
    Oslo University Hospital)

  • Raquelle I. Mesholam-Gately

    (Harvard Medical School
    Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center)

  • Andres Metspalu

    (University of Tartu)

  • Patricia T. Michie

    (University of Newcastle)

  • Lili Milani

    (University of Tartu)

  • Vihra Milanova

    (Alexandrovska University Hospital)

  • Marina Mitjans

    (Max Planck Institute of Experimental Medicine)

  • Espen Molden

    (University of Oslo
    Diakonhjemmet Hospital)

  • Esther Molina

    (University of Granada)

  • María Dolores Molto

    (Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)
    Universidad de Valencia
    Biomedical Research Institute INCLIVA)

  • Valeria Mondelli

    (National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London
    King’s College London)

  • Carmen Moreno

    (Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)
    General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense)

  • Christopher P. Morley

    (State University of New York, Upstate Medical University)

  • Gerard Muntané

    (Hospital Universitari Institut Pere Mata, IISPV, Universitat Rovira i Virgili, CIBERSAM
    Universitat Pompeu Fabra, PRBB)

  • Kieran C. Murphy

    (Royal College of Surgeons in Ireland)

  • Inez Myin-Germeys

    (KU Leuven)

  • Igor Nenadić

    (Philipps Universität Marburg
    Jena University Hospital)

  • Gerald Nestadt

    (Johns Hopkins University School of Medicine)

  • Liene Nikitina-Zake

    (Latvian Biomedical Research and Study Centre)

  • Cristiano Noto

    (Universidade Federal de São Paulo
    Universidade Federal de São Paulo)

  • Keith H. Nuechterlein

    (Geffen School of Medicine, University of California Los Angeles)

  • Niamh Louise O’Brien

    (University College London)

  • F. Anthony O’Neill

    (Queen’s University Belfast)

  • Sang-Yun Oh

    (University of California at Santa Barbara
    Lawrence Berkeley National Laboratory)

  • Ann Olincy

    (University of Colorado Denver)

  • Vanessa Kiyomi Ota

    (Universidade Federal de São Paulo
    Universidade Federal de São Paulo)

  • Christos Pantelis

    (NorthWestern Mental Health
    University of Melbourne and Melbourne Health
    University of Melbourne
    University of Melbourne)

  • George N. Papadimitriou

    (National and Kapodistrian University of Athens, Eginition Hospital)

  • Mara Parellada

    (Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)
    General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense)

  • Tiina Paunio

    (National Institute for Health and Welfare
    University of Helsinki and Helsinki University Central Hospital)

  • Renata Pellegrino

    (Children’s Hospital of Philadelphia, Leonard Madlyn Abramson Research Center)

  • Sathish Periyasamy

    (University of Queensland
    University of Queensland)

  • Diana O. Perkins

    (University of North Carolina)

  • Bruno Pfuhlmann

    (Weißer Hirsch)

  • Olli Pietiläinen

    (Broad Institute of MIT and Harvard
    Harvard University
    University of Helsinki)

  • Jonathan Pimm

    (University College London)

  • David Porteous

    (University of Edinburgh, Western General Hospital)

  • John Powell

    (King’s College London)

  • Diego Quattrone

    (King’s College London
    National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London
    South London and Maudsley NHS Mental Health Foundation Trust)

  • Digby Quested

    (Warneford Hospital
    University of Oxford)

  • Allen D. Radant

    (University of Washington
    VA Puget Sound Health Care System)

  • Antonio Rampino

    (University of Bari ‘Aldo Moro’)

  • Mark H. Rapaport

    (University of Utah School of Medicine)

  • Anna Rautanen

    (Roche Innovation Center Basel, F. Hoffman-La Roche)

  • Abraham Reichenberg

    (Icahn School of Medicine at Mount Sinai)

  • Cheryl Roe

    (SUNY Upstate Medical University)

  • Joshua L. Roffman

    (Massachusetts General Hospital)

  • Julian Roth

    (Julius-Maximilians-Universität Würzburg)

  • Matthias Rothermundt

    (University of Münster)

  • Bart P. F. Rutten

    (School for Mental Health and Neuroscience, Maastricht University Medical Centre)

  • Safaa Saker-Delye

    (Généthon)

  • Veikko Salomaa

    (THL–Finnish Institute for Health and Welfare)

  • Julio Sanjuan

    (Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)
    Biomedical Research Institute INCLIVA
    University of Valencia, Hospital Clínico Universitario de Valencia)

  • Marcos Leite Santoro

    (Universidade Federal de São Paulo
    Universidade Federal de São Paulo)

  • Adam Savitz

    (Janssen Research and Development)

  • Ulrich Schall

    (Hunter Medical Research Institute
    University of Newcastle, Mater Hospital, McAuley Centre)

  • Rodney J. Scott

    (University of Newcastle
    Hunter Medical Research Institute
    NSW Health Pathology North)

  • Larry J. Seidman

    (Harvard Medical School
    Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center)

  • Sally Isabel Sharp

    (University College London)

  • Jianxin Shi

    (National Cancer Institute)

  • Larry J. Siever

    (Icahn School of Medicine at Mount Sinai
    James J. Peters VA Medical Center)

  • Engilbert Sigurdsson

    (University of Iceland
    Landspitali University Hospital)

  • Kang Sim

    (West Region, Institute of Mental Health
    National University of Singapore
    Nanyang Technological University)

  • Nora Skarabis

    (Charité - Universitätsmedizin)

  • Petr Slominsky

    (Institute of Molecular Genetics of National Research Centre “Kurchatov Institute”)

  • Hon-Cheong So

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Janet L. Sobell

    (University of Southern California)

  • Erik Söderman

    (Karolinska Institutet and Stockholm Health Care Services, Stockholm Region)

  • Helen J. Stain

    (Leeds Trinity University
    Stavanger University Hospital)

  • Nils Eiel Steen

    (Oslo University Hospital
    University of Oslo)

  • Agnes A. Steixner-Kumar

    (Max Planck Institute of Experimental Medicine)

  • Elisabeth Stögmann

    (Medical University of Vienna)

  • William S. Stone

    (Harvard Medical School Department of Psychiatry at Beth Israel Deaconess Medical Center
    Massachusetts Mental Health Center)

  • Richard E. Straub

    (Lieber Institute for Brain Development)

  • Fabian Streit

    (University of Heidelberg)

  • Eric Strengman

    (University Medical Centre Utrecht)

  • T. Scott Stroup

    (Columbia University)

  • Mythily Subramaniam

    (Research Division, Institute of Mental Health
    National University of Singapore)

  • Catherine A. Sugar

    (Geffen School of Medicine, University of California Los Angeles
    Fielding School of Public Health, University of California Los Angeles)

  • Jaana Suvisaari

    (THL–Finnish Institute for Health and Welfare)

  • Dragan M. Svrakic

    (Washington University)

  • Neal R. Swerdlow

    (University of California San Diego)

  • Jin P. Szatkiewicz

    (University of North Carolina)

  • Thi Minh Tam Ta

    (Charité – Universitätsmedizin Berlin
    Berlin Institute of Health (BIH))

  • Atsushi Takahashi

    (Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences)

  • Chikashi Terao

    (Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences)

  • Florence Thibaut

    (Université de Paris, Faculté de Médecine, Hôpital Cochin-Tarnier
    INSERM U1266, Institut de Psychiatrie et de Neurosciences)

  • Draga Toncheva

    (Medical University
    Bulgarian Academy of Science)

  • Paul A. Tooney

    (University of Newcastle
    Hunter Medical Research Institute
    University of Newcastle)

  • Silvia Torretta

    (University of Bari ‘Aldo Moro’)

  • Sarah Tosato

    (University of Verona)

  • Gian Battista Tura

    (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli)

  • Bruce I. Turetsky

    (University of Pennsylvania)

  • Alp Üçok

    (Istanbul University)

  • Arne Vaaler

    (Trondheim University Hospital
    Norwegian University of Science and Technology)

  • Therese Amelsvoort

    (National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London
    School for Mental Health and Neuroscience, Maastricht University Medical Centre)

  • Ruud Winkel

    (School for Mental Health and Neuroscience, Maastricht University Medical Centre
    KU Leuven)

  • Juha Veijola

    (University of Oulu
    Oulu University Hospital and University of Oulu)

  • John Waddington

    (Royal College of Surgeons in Ireland)

  • Henrik Walter

    (Charité - Universitätsmedizin)

  • Anna Waterreus

    (University of Western Australia
    University of Western Australia)

  • Bradley T. Webb

    (Virginia Commonwealth University)

  • Mark Weiser

    (Sheba Medical Center)

  • Nigel M. Williams

    (Cardiff University)

  • Stephanie H. Witt

    (University of Heidelberg)

  • Brandon K. Wormley

    (Virginia Commonwealth University)

  • Jing Qin Wu

    (Baker Heart and Diabetes Institute)

  • Zhida Xu

    (GGz Centraal)

  • Robert Yolken

    (Stanley Neurovirology Laboratory, Johns Hopkins University School of Medicine)

  • Clement C. Zai

    (Centre for Addiction and Mental Health
    University of Toronto)

  • Wei Zhou

    (Shanghai Jiao Tong University)

  • Feng Zhu

    (The First Affiliated Hospital of Xi’an Jiaotong University
    Center for Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University)

  • Fritz Zimprich

    (Medical University of Vienna)

  • Eşref Cem Atbaşoğlu

    (Icahn School of Medicine at Mount Sinai
    Ankara University)

  • Muhammad Ayub

    (Queens University Kingston)

  • Christian Benner

    (University of Helsinki)

  • Alessandro Bertolino

    (University of Bari ‘Aldo Moro’)

  • Donald W. Black

    (University of Iowa Carver College of Medicine)

  • Nicholas J. Bray

    (Cardiff University)

  • Gerome Breen

    (King’s College London)

  • Nancy G. Buccola

    (School of Nursing, Louisiana State University Health Sciences Center)

  • William F. Byerley

    (University of California San Francisco)

  • Wei J. Chen

    (National Health Research Institutes
    National Taiwan University)

  • C. Robert Cloninger

    (Washington University)

  • Benedicto Crespo-Facorro

    (University of Sevilla, CIBERSAM IBiS
    Universidad del Sevilla)

  • Gary Donohoe

    (National University of Ireland Galway)

  • Robert Freedman

    (University of Colorado Denver)

  • Cherrie Galletly

    (University of Adelaide
    Ramsay Health Care (SA) Mental Health
    Northern Adelaide Local Health Network)

  • Michael J. Gandal

    (University of California Los Angeles)

  • Massimo Gennarelli

    (University of Brescia
    Genetic Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli)

  • David M. Hougaard

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
    Statens Serum Institut)

  • Hai-Gwo Hwu

    (National Taiwan University
    College of Medicine and National Taiwan University Hospital, National Taiwan University)

  • Assen V. Jablensky

    (University of Western Australia)

  • Steven A. McCarroll

    (Broad Institute of MIT and Harvard)

  • Jennifer L. Moran

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Ole Mors

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
    Aarhus University Hospital)

  • Preben B. Mortensen

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
    Aarhus University)

  • Bertram Müller-Myhsok

    (Max Planck Institute of Psychiatry
    Munich Cluster for Systems Neurology
    University of Liverpool)

  • Amanda L. Neil

    (University of Tasmania)

  • Merete Nordentoft

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
    University of Copenhagen)

  • Michele T. Pato

    (Rutgers University, Robert Wood Johnson Medical School
    Rutgers University, New Jersey Medical School)

  • Tracey L. Petryshen

    (Massachusetts General Hospital, Harvard Medical School)

  • Matti Pirinen

    (University of Helsinki
    University of Helsinki
    University of Helsinki)

  • Ann E. Pulver

    (Johns Hopkins University School of Medicine)

  • Thomas G. Schulze

    (University Hospital, LMU Munich
    SUNY Upstate Medical University
    University Medical Center Göttingen
    The Johns Hopkins University)

  • Jeremy M. Silverman

    (Icahn School of Medicine at Mount Sinai
    James J. Peters VA Medical Center)

  • Jordan W. Smoller

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital, Harvard Medical School)

  • Eli A. Stahl

    (Icahn School of Medicine at Mount Sinai
    Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
    Regeneron Genetics Center)

  • Debby W. Tsuang

    (University of Washington
    VA Puget Sound Health Care System)

  • Elisabet Vilella

    (Hospital Universitari Institut Pere Mata, IISPV, Universitat Rovira i Virgili, CIBERSAM)

  • Shi-Heng Wang

    (College of Public Health, China Medical University)

  • Shuhua Xu

    (Fudan University
    ShanghaiTech University
    Chinese Academy of Sciences)

  • Rolf Adolfsson

    (Umeå University)

  • Celso Arango

    (Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)
    General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense)

  • Bernhard T. Baune

    (University of Münster
    University of Melbourne
    University of Melbourne)

  • Sintia Iole Belangero

    (Universidade Federal de São Paulo
    Universidade Federal de São Paulo)

  • Anders D. Børglum

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
    Aarhus University
    Center for Genomics and Personalized Medicine)

  • David Braff

    (University of California San Diego
    VISN 22, Mental Illness Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System)

  • Elvira Bramon

    (University College London)

  • Joseph D. Buxbaum

    (Icahn School of Medicine at Mount Sinai)

  • Dominique Campion

    (INSERM
    Centre Hospitalier du Rouvray)

  • Jorge A. Cervilla

    (San Cecilio University Hospital, University of Granada)

  • Sven Cichon

    (University Hospital Basel
    University of Basel
    Research Center Juelich)

  • David A. Collier

    (Eli Lilly and Company)

  • Aiden Corvin

    (Trinity College Dublin)

  • David Curtis

    (University College London
    Queen Mary University London)

  • Marta Di Forti

    (King’s College London
    National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London
    South London and Maudsley NHS Mental Health Foundation Trust)

  • Enrico Domenici

    (University of Trento)

  • Hannelore Ehrenreich

    (Max Planck Institute of Experimental Medicine)

  • Valentina Escott-Price

    (Cardiff University
    Cardiff University)

  • Tõnu Esko

    (University of Tartu
    Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard)

  • Ayman H. Fanous

    (Veterans Affairs New York Harbor Healthcare System
    Phoenix VA Healthcare System
    Banner-University Medical Center)

  • Anna Gareeva

    (Department of Human Molecular Genetics of the Institute of Biochemistry and Genetics of the Ufa Federal Research Center of the Russian Academy of Sciences (IBG UFRC RAS)
    Federal State Educational Institution of Highest Education Bashkir State Medical University of Public Health Ministry of Russian Federation (BSMU))

  • Micha Gawlik

    (Julius-Maximilians-Universität Würzburg)

  • Pablo V. Gejman

    (NorthShore University HealthSystem
    The University of Chicago)

  • Michael Gill

    (Trinity College Dublin)

  • Stephen J. Glatt

    (SUNY Upstate Medical University)

  • Vera Golimbet

    (Mental Health Research Center)

  • Kyung Sue Hong

    (Sungkyunkwan University School of Medicine, Samsung Medical Center)

  • Christina M. Hultman

    (Karolinska Institutet)

  • Steven E. Hyman

    (Broad Institute of MIT and Harvard
    Harvard University)

  • Nakao Iwata

    (Fujita Health University School of Medicine)

  • Erik G. Jönsson

    (Karolinska Institutet and Stockholm Health Care Services, Stockholm Region
    University of Oslo)

  • René S. Kahn

    (Rudolf Magnus Institute of Neuroscience
    Icahn School of Medicine at Mount Sinai)

  • James L. Kennedy

    (Centre for Addiction and Mental Health
    University of Toronto)

  • Elza Khusnutdinova

    (Department of Human Molecular Genetics of the Institute of Biochemistry and Genetics of the Ufa Federal Research Center of the Russian Academy of Sciences (IBG UFRC RAS)
    Federal State Educational Institution of Highest Education Bashkir State Medical University of Public Health Ministry of Russian Federation (BSMU))

  • George Kirov

    (Cardiff University)

  • James A. Knowles

    (Keck School of Medicine at University of Southern California
    State University of New York, Downstate Health Sciences University)

  • Marie-Odile Krebs

    (INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Université de Paris, GHU Paris Psychiatrie & Neurosciences)

  • Claudine Laurent-Levinson

    (Hôpital Universitaire de la Pitié-Salpêtrière
    Hôpital Universitaire de la Pitié-Salpêtrière)

  • Jimmy Lee

    (Institute of Mental Health
    Nanyang Technological University)

  • Todd Lencz

    (Zucker Hillside Hospital
    Institute of Behavioral Science, Feinstein Institutes for Medical Research
    Zucker School of Medicine at Hofstra/Northwell)

  • Douglas F. Levinson

    (Stanford University)

  • Qingqin S. Li

    (Janssen Research and Development)

  • Jianjun Liu

    (Genome Institute of Singapore, A*STAR
    Yong Loo Lin School of Medicine, National University of Singapore)

  • Anil K. Malhotra

    (Zucker Hillside Hospital
    Institute of Behavioral Science, Feinstein Institutes for Medical Research
    Zucker School of Medicine at Hofstra/Northwell)

  • Dheeraj Malhotra

    (Roche Innovation Center Basel, F. Hoffman-La Roche)

  • Andrew McIntosh

    (University of Edinburgh, Royal Edinburgh Hospital)

  • Andrew McQuillin

    (University College London)

  • Paulo R. Menezes

    (University of São Paulo)

  • Vera A. Morgan

    (University of Western Australia
    University of Western Australia)

  • Derek W. Morris

    (National University of Ireland Galway)

  • Bryan J. Mowry

    (University of Queensland
    University of Queensland)

  • Robin M. Murray

    (National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London)

  • Vishwajit Nimgaonkar

    (University of Pittsburgh)

  • Markus M. Nöthen

    (University of Bonn)

  • Roel A. Ophoff

    (University of California Los Angeles
    University of California Los Angeles
    Erasmus University Medical Center)

  • Sara A. Paciga

    (Pfizer Worldwide Research and Development)

  • Aarno Palotie

    (University of Helsinki
    Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Carlos N. Pato

    (Rutgers University, Robert Wood Johnson Medical School
    Rutgers University, New Jersey Medical School)

  • Shengying Qin

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University School of Medicine)

  • Marcella Rietschel

    (University of Heidelberg)

  • Brien P. Riley

    (Virginia Commonwealth University)

  • Margarita Rivera

    (University of Granada
    University of Granada)

  • Dan Rujescu

    (Medical University of Vienna)

  • Meram C. Saka

    (Ankara University)

  • Alan R. Sanders

    (NorthShore University HealthSystem
    The University of Chicago)

  • Sibylle G. Schwab

    (University of Wollongong
    Illawarra Health and Medical Research Institute)

  • Alessandro Serretti

    (University of Bologna)

  • Pak C. Sham

    (The University of Hong Kong
    The University of Hong Kong
    The University of Hong Kong)

  • Yongyong Shi

    (Qingdao University
    Shanghai Jiao Tong University)

  • David Clair

    (University of Aberdeen)

  • Hreinn Stefánsson

    (deCODE Genetics, Amgen)

  • Kari Stefansson

    (deCODE Genetics, Amgen)

  • Ming T. Tsuang

    (University of California San Diego
    University of California San Diego)

  • Jim Os

    (King’s College London
    University Medical Center Utrecht, Department of Psychiatry)

  • Marquis P. Vawter

    (School of Medicine, University of California Irvine)

  • Daniel R. Weinberger

    (Lieber Institute for Brain Development)

  • Thomas Werge

    (Copenhagen University Hospital
    University of Copenhagen
    University of Copenhagen
    The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH)

  • Dieter B. Wildenauer

    (University of Western Australia)

  • Xin Yu

    (Peking University Institute of Mental Health
    National Clinical Research Center for Mental Disorders, NHC Key Laboratory of Mental Health (Peking University) and Chinese Academy of Medical Sciences Research Unit)

  • Weihua Yue

    (Peking University Institute of Mental Health
    National Clinical Research Center for Mental Disorders, NHC Key Laboratory of Mental Health (Peking University) and Chinese Academy of Medical Sciences Research Unit
    Peking University)

  • Peter A. Holmans

    (Cardiff University)

  • Andrew J. Pocklington

    (Cardiff University)

  • Panos Roussos

    (Icahn School of Medicine at Mount Sinai
    Mental Illness Research, Education, and Clinical Center (VISN 2 South), James J. Peters VA Medical Center)

  • Evangelos Vassos

    (King’s College London
    National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London
    Oxford Health NHS Foundation Trust)

  • Matthijs Verhage

    (University Medical Center Amsterdam
    VU University Amsterdam and VU Medical Center)

  • Peter M. Visscher

    (University of Queensland)

  • Jian Yang

    (University of Queensland
    Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine)

  • Danielle Posthuma

    (VU University Amsterdam and VU Medical Center)

  • Ole A. Andreassen

    (University of Oslo
    Oslo University Hospital)

  • Kenneth S. Kendler

    (Virginia Commonwealth University)

  • Michael J. Owen

    (Cardiff University)

  • Naomi R. Wray

    (University of Queensland
    University of Queensland)

  • Mark J. Daly

    (Massachusetts General Hospital
    Broad Institute of MIT and Harvard
    University of Helsinki)

  • Hailiang Huang

    (Massachusetts General Hospital
    Broad Institute of MIT and Harvard
    Harvard Medical School)

  • Benjamin M. Neale

    (Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Patrick F. Sullivan

    (Karolinska Institutet
    University of North Carolina
    University of North Carolina)

  • Stephan Ripke

    (Charité - Universitätsmedizin
    Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • James T. R. Walters

    (Cardiff University)

  • Michael C. O’Donovan

    (Cardiff University)

Abstract

Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.

Suggested Citation

  • Vassily Trubetskoy & Antonio F. Pardiñas & Ting Qi & Georgia Panagiotaropoulou & Swapnil Awasthi & Tim B. Bigdeli & Julien Bryois & Chia-Yen Chen & Charlotte A. Dennison & Lynsey S. Hall & Max Lam & K, 2022. "Mapping genomic loci implicates genes and synaptic biology in schizophrenia," Nature, Nature, vol. 604(7906), pages 502-508, April.
  • Handle: RePEc:nat:nature:v:604:y:2022:i:7906:d:10.1038_s41586-022-04434-5
    DOI: 10.1038/s41586-022-04434-5
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